Results 41 to 50 of about 12,564,476 (214)

Sonographic Pattern of Subacute Thyroiditis Is HLA-Dependent

Frontiers in Endocrinology, 2019
Background: Since 1977 the susceptibility to SAT has been known to be HLA-B*35-related in ~70% of patients. Recently it has been demonstrated that SAT is associated with the presence of HLA-B*18:01 and DRB1*01, as well as with HLA-C*04:01.
Magdalena Stasiak, Bogusław Tymoniuk, Zbigniew Adamczewski, Zbigniew Adamczewski, Bartłomiej Stasiak, Andrzej Lewiński, Andrzej Lewiński   +6 more
doaj   +1 more source

E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I [PDF]

, 2005
Papillomaviruses have evolved mechanisms that result in escape from host immune surveillance. The E5 protein is expressed early in papillomavirus infection in the deep layers of the infected epithelium.
Marchetti, Barbara, O'Brien, P.M., Ashrafi, G. Hossein, Haghshenas, Mohammad R., O'Brien, Philippa M., Ashrafi, G.H., Haghshenas, M.R., Campo, M.S., Marchetti, B., Campo, M. Saveria   +9 more
core   +1 more source

Homozygosity in any HLA locus is a risk factor for specific antibody production: the taboo concept 2.0

Frontiers in Immunology
ObjectiveIn a cooperative study of the University Hospital Leipzig, University of Leipzig, and the Charité Berlin on kidney transplant patients, we analysed the occurrence of HLA-specific antibodies with respect to the HLA setup of the patients. We aimed
Henry Loeffler-Wirth, Claudia Lehmann, Nils Lachmann, Ilias Doxiadis   +3 more
doaj   +1 more source

HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c.

, 2002
Few human CD8(+) T-cell epitopes in mycobacterial antigens have been described to date. Here we have identified a novel HLA-B*35-restricted CD8(+) T-cell epitope in Mycobacterium tuberculosis Rv2903c based on a reverse immunogenetics approach.
Lukey, Pauline T, Abdulrahman S. Hammond, McAdam, Keith PWJ, Klein, Michèl R, Jaye, Assan, Smith, Steve M, Michèl R. Klein, Assan Jaye, Steve M. Smith, Hammond, Abdulrahman S, Pauline T. Lukey, Keith P. W. J. McAdam   +11 more
core   +1 more source

The mechanism of humoral immune response to allogeneic organ transplantation

Вестник трансплантологии и искусственных органов, 2017
The problem of antibody-mediated rejection of donor organ remains extremely relevant. The main targets of the antibodies are mainly donor HLA-antigens (Human Leucocyte Antigens), expressed, in particular, by the cells of graft vascular endothelium.
A. S. Berkos, G. V. Nikolaev
doaj   +1 more source

Analysis of HLA allele-specific antibodies and Eplets in patients with platelet transfusion refractoriness

Zhongguo shuxue zazhi, 2022
Objective To analyze the specificity and Eplets of HLA allele-specific antibody in patients with platelet transfusion refractoriness (PTR). Methods HLA-A and B genotypes were detected by PCR-SBT, and HLA-Ⅰ antibodies in patients′ serum were detected by ...
Bing ZHANG, Xinyu HUANG, Ying LIU, Gang XU, Shu CHEN, Xianguo XU, Faming ZHU   +6 more
doaj   +1 more source

Human Leukocyte Antigen - HLA B*27: Unraveling the Link to Pathogenesis

Indian Journal of Rheumatology, 2020
The association of spondyloarthritis (SpA) with human leukocyte antigen-B*27 (HLA-B*27) is one of the strongest known for a non-monogenic disease. How HLA-B*27 determines the aetiopathogenesis of SpA and disposes toward this group of disease has perplexed rheumatologists for decades.
Sakir Ahmed, Ramnath Misra
openaire   +2 more sources

Nine Human Leukocyte Antigen (HLA) Class I Alleles are Omnipotent Against 11 Antigens Expressed in Melanoma Tumors

Cancer Informatics
Objective: Host immunogenetics (Human Leukocyte Antigen, HLA) play a critical role in the human immune response to melanoma, influencing both melanoma prevalence and immunotherapy outcomes.
Apostolos P Georgopoulos, Lisa M James, Matthew Sanders   +2 more
doaj   +1 more source

HLA-B*5701 screening for hypersensitivity to Abacavir [PDF]

, 2008
Background Hypersensitivity reaction to abacavir is strongly associated with the presence of the HLA-B*5701 allele. This study was designed to establish the effectiveness of prospective HLA-B*5701 screening to prevent the hypersensitivity reaction to ...
Jagel-Guedes, E., Kozyrev, O., Phillips, E., Fitch, N., Thorborn, D., Molina, J-M, Hughes, A., Cid, J.F., Rugina, S., Nolan, D., Carosi, G., Hay, P., Ryan, S., Tomazic, J., Hughes, S., Benbow, A., Mallal, S., Workman, C.   +17 more
core  

Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity? [PDF]

, 2006
Background: There are reasons to expect an association with Alzheimer's disease (AD) within the HLA region. The HLA-B & C genes have, however, been relatively understudied.
Smith, AD, Horton Roger, Barnardo Martin CNM, Stephan Beck, Warden Donald R, Warden, DR, Martin CNM Barnardo, Barnetson, L, Smith A David, Andrew Sutherland, Lehmann, DJ, Beck Stephan, Barnardo, MC, Isabel Quiroga, Fuggle Susan, Barnetson Lin, Barnardo, MCNM, Quiroga Isabel, Lehmann Donald J, Roger Horton, Beck, S, Susan Fuggle, Donald R Warden, Fuggle, S, Sutherland Andrew, Sutherland, A, Donald J Lehmann, Lin Barnetson, A David Smith, Quiroga, I, Horton, R   +30 more
core   +1 more source