Results 261 to 270 of about 375,043 (313)
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Genes and Antigens of the HLA-D Region
1986The role of the major histocompatibility complex (MHC) in rejections of transplanted organs was recognized early. The combined efforts of immunologists and immunogeneticists demonstrated that the human MHC represents one of the most genetically polymorphic loci hitherto identified.
P. A. Peterson, L. Rask
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HLA-D Related Antigens in Inflammatory Bowel Disease
1981There is good evidence that genetic as well as environmental factors are important in the aetiology of inflammatory bowel disease (1). However, studies of HLA-A and -B specificities have not shown consistent differences between patients and controls. Nevertheless an investigation of the HLA-D related [DR] antigens in such patients would be of interest ...
W. R. Burnham +2 more
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Generation of discriminatory PL against HLA-D antigens not detected by serology
Human Immunology, 1981A family was studied in which the father and the mother were both homozygous for the HLA-DR antigens. All children responded to the parents in MLC, even though each had a copy of the parental DR antigen, implying that they recognized a difference. When the father or the mother was sensitized in PLT against any child, all siblings could restimulate ...
K S, Zier, B, Gansbacher
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Influence of HLA‐D/DR antigen disparity in CTL generation in vitro
Tissue Antigens, 1983This report describes the influence of HLA‐D/‐DR antigen disparity upon the level of cytotoxicity in allogeneic in vitro cultures.Allogeneic cultures, between unrelated HLA‐D/‐DR full house donors, tested in CML gave three different levels of cytotoxicity, termed weak, intermediate and strong cytotoxicity.
H E, Johnsen +3 more
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T cells specific for different antigens express different HLA‐D region products
European Journal of Immunology, 1985AbstractT cell lines and clones were analyzed for surface expression of la antigens using monoclonal antibodies (mAb) that detect monomorphic and polymorphic epitopes on la molecules encoded by the HLA‐DR and HLA‐DQ gene clusters. All mAb bound to B lymphocytes or lymphoblastoid cell lines of the same individuals from whom the T cells were derived ...
D J, Schendel, J P, Johnson
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Scandinavian Journal of Immunology, 1979
The proliferative response of sensitized human T lymphocytes to purified protein derivative (PPD) and to trinitrophenyl (TNP)‐conjugated autologous cells in vitro is restricted by self HLA‐D/DR determinants. Here we report that the PPD‐specific response is strictly related to the content of phagocytosing celts (macrophages, M) in the cultures and that ...
B O, Bergholtz, E, Thorsby
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The proliferative response of sensitized human T lymphocytes to purified protein derivative (PPD) and to trinitrophenyl (TNP)‐conjugated autologous cells in vitro is restricted by self HLA‐D/DR determinants. Here we report that the PPD‐specific response is strictly related to the content of phagocytosing celts (macrophages, M) in the cultures and that ...
B O, Bergholtz, E, Thorsby
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HLA‐D/DR restriction of proliferative T cell responses to antigen
Tissue Antigens, 1982Antigen‐specific T cell blasts may be separated from alloreactive cells on Percoll gradients. The absence of alloreactivity allowed us to study HLA‐D/DR restriction of proliferative T cell responses towards PPD and HSV antigens using allogeneic antigen‐presenting cells.
E. J. Berle, A. B. Thoresen, E. Thorsby
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HLA—DR Antigens in Black North‐Americans and Their Association with HLA—D
Tissue Antigens, 1979A random population of 108 Black North‐Americans, 79 of whom had also been typed for HLA—D in Mixed Leukocyte Culture (MLC), were serologically tested for DRw with Seventh International Histocompatibility Workshop trays. Clusters of B cell alloantisera were identified which defined several DRw antigens.
R J, Duquesnoy +4 more
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HLA-D and -DR antigens on human amniotic fluid cells. I. Lack of expression of HLA-D.
Tissue antigens, 1983Human amniotic fluid cells, known to express HLA-A, -B, and -C antigens, were tested for the presence of lymphocyte-stimulating antigens (LD or HLA-D) using modifications of the mixed lymphocyte culture (MLC) and primed lymphocyte typing (PLT) tests. Peripheral blood lymphocytes were co-cultured with various concentrations of allogeneic amniotic fluid ...
E, Valentine-Thon +3 more
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Tissue antigens, 1983
On the basis of studies with 6 HTCs in four different families the new cluster DB3 identified in the 8th Workshop can be considered an established specificity of the HLA-D series. In 112 healthy Caucasoids resident in South East England the frequency of this antigen was 2.6% similar to the frequency found in 142 Caucasoid patients with rheumatoid ...
Jaraquemada, D +5 more
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On the basis of studies with 6 HTCs in four different families the new cluster DB3 identified in the 8th Workshop can be considered an established specificity of the HLA-D series. In 112 healthy Caucasoids resident in South East England the frequency of this antigen was 2.6% similar to the frequency found in 142 Caucasoid patients with rheumatoid ...
Jaraquemada, D +5 more
openaire +2 more sources