Results 61 to 70 of about 13,772,328 (296)

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Mice with a diverse human T cell receptor repertoire selected on multiple HLA class I molecules

Nature Communications
T cell receptor (TCR) gene therapy is an effective cancer treatment. Ideally, the TCR should be of human origin and have optimal avidity, e.g., isolated from a tumor antigen-non-tolerant host.
Arunraj Dhamodaran, Xiaojing Chen, Niklas Fellmer, Deepti Agrawal, Eric Danner, Ralf Kühn, Thomas Blankenstein   +6 more
doaj   +1 more source

Robust HLA-B-restricted CD8+ T-cell responses in chronic HBV infection

JHEP Reports
Background & Aims: The function and quantity of CD8+ T-cell responses is superior in acute vs. chronic HBV infection. However, whether different HBV-derived epitopes are targeted in these distinct courses of HBV infection remains unclear. Methods: We
Julia Lang-Meli, Anna-Lena Denecke, Johannes Ptok, Philipp Ehrenmann, Elahe Salimi Alizei, Hendrik Luxenburger, Michelle Maas, Muthamia Kiraithe, Felix Jacobi, Giuseppe Rusignuolo, Isabel Schulien, Emma Gostick, Sian Llewellyn-Lacey, Florian Emmerich, Bertram Bengsch, Tobias Boettler, David A. Price, Andreas Walker, Jörg Timm, Robert Thimme, Maike Hofmann, Christoph Neumann-Haefelin   +21 more
doaj   +1 more source

Isolation of Stem Cells of the Degenerated Lumbar Intervertebral Disc Using a Low Cost and Very Effective Technique

Global Spine Journal, 2014
Introduction The limitations of regenerative therapy of the tissue using stem cells are, among others, the length of time until a satisfactory amount of viable cells is obtained for the therapy and the high financial cost.
A. Falavigna, M. Peletti-Figueiró, I. Silvera Aguiar, M. Roesch-Ely, D. Cantarelli Machado, J. A. Pêgas Henriques   +5 more
doaj   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

A systematic review of T cell epitopes defined from the proteome of human immunodeficiency virus

Virus Research
Background: Human immunodeficiency virus (HIV) persists as a formidable and far - reaching threat without a cure. T cells are crucial for antiviral immunity and pathology in HIV patients, with specific T cell epitopes potentially key to effective ...
Yan Ding, Ling Huang, Yandan Wu, Jialai Yan   +3 more
doaj   +1 more source

Resúmenes de Trabajos Libres

Revista Alergia México, 2018
Presentación   En septiembre de 2017, la Asociación Colombiana de Alergia, Asma e Inmunología (ACAAI) y la Organización Mundial de Alergia (WAO) celebraron conjuntamente en la Ciudad de Cartagena, Colombia, dos eventos únicos: el XI Congreso ...
Revista CMICA
doaj   +1 more source

HLA-D associated alloantisera react with molecules similar to Ia antigens. [PDF]

Proceedings of the National Academy of Sciences, 1977
Two human alloantisera specific to bone marrow-derived lymphocytes (B cells) were shown to precipitate polypeptide chains of 29,000 and 34,000 daltons from human lymphoblastoid B cell lines. These molecules are similar to murine Ia antigens and are also precipitated by a rabbit B-cell specific heteroantiserum.
M J, Giphart, J F, Kaufman, A, Fuks, D, Albrechtsen, B G, Solheim, J W, Bruning, J L, Strominger   +6 more
openaire   +2 more sources

HLA class II polymorphisms and susceptibility to recurrent respiratory papillomatosis. [PDF]

, 2003
Published ...
Hart, K.W., Gelder, CM, Bunce, M, Borysiewicz, L, Williams, G., Marshall, SE, Williams, O.M., Borysiewicz, L., Gelder, C.M., Williams, OM, Ingrams, D, Hart, KW, Bull, P, Ingrams, D., Wall, S., Welsh, K., Welsh, K, Wall, S, Marshall, S.E.F., Williams, G, Bull, P., Bunce, M.   +21 more
core   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

Advanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo, Hansen Lin, Haoqian Feng, Lei Tan, Xi Liu, Yong Huang, Junjie Cen, Jiajie Chen, Xinwei Zhou, Mingjie Lin, Wuyuan Liao, Zheyu Ai, Minyu Chen, Yinghan Wang, Wei Chen, Junhang Luo, Yanping Liang   +16 more
wiley   +1 more source