Results 1 to 10 of about 1,839,216 (336)

HLA-DR in Cytotoxic T Lymphocytes Predicts Breast Cancer Patients' Response to Neoadjuvant Chemotherapy [PDF]

Frontiers in Immunology, 2018
Prediction of breast cancer response to Neoadjuvant Chemotherapy (NACT) is an urgent need to promptly direct non-responder patients to alternative therapies.
Diana P. Saraiva, António Jacinto, Paula Borralho, Paula Borralho, Sofia Braga, Sofia Braga, Sofia Braga, M. Guadalupe Cabral   +7 more
doaj   +5 more sources

Quantitative Predictions of Peptide Binding to Any HLA-DR Molecule of Known Sequence: NetMHCIIpan [PDF]

PLoS Computational Biology, 2008
CD4 positive T helper cells control many aspects of specific immunity. These cells are specific for peptides derived from protein antigens and presented by molecules of the extremely polymorphic major histocompatibility complex (MHC) class II system. The
Morten Nielsen, Claus Lundegaard, Alessandro Sette   +2 more
exaly   +8 more sources

Persistent High Percentage of HLA-DR+CD38high CD8+ T Cells Associated With Immune Disorder and Disease Severity of COVID-19

Frontiers in Immunology, 2021
BackgroundThe global outbreak of coronavirus disease 2019 (COVID-19) has turned into a worldwide public health crisis and caused more than 100,000,000 severe cases.
Juan Du, Lirong Wei, Guoli Li, Mingxi Hua, Yao Sun, Di Wang, Kai Han, Yonghong Yan, Chuan Song, Rui Song, Henghui Zhang, Junyan Han, Jingyuan Liu, Yaxian Kong   +13 more
doaj   +2 more sources

Expression of HLA-DR in pheripheral nerve of amyotrophic lateral sclerosis [PDF]

Arquivos de Neuro-Psiquiatria, 1994
To investigate the possibility of local antigen presentation within the peripheral nerve in amyotrophic lateral sclerosis (ALS), cryostat sections of 83 peripheral nerve biopsies were stained for the demonstration of HLA-DR using a monoclonal antibody ...
A.S.B. Oliveira, E. Isozaki, D. Younger, A.A. Gabbai, A.P. Hays   +4 more
doaj   +2 more sources

CD14+ CD15- HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure. [PDF]

Gut, 2017
OBJECTIVE: Immune paresis in patients with acute-on-chronic liver failure (ACLF) accounts for infection susceptibility and increased mortality. Immunosuppressive mononuclear CD14+HLA-DR- myeloid-derived suppressor cells (M-MDSCs) have recently been ...
Adams, DH, Antoniades, CG, Bernsmeier, C, Brenig, R, Khamri, W, Lebosse, FJ, Nathwani, R, Patel, VC, Pop, OT, Singanayagam, A, Thursz, MR, Tidswell, R, Triantafyllou, E, Wendon, JA, Weston, CJ   +14 more
core   +3 more sources

Memory CD4 + T-Cells Expressing HLA-DR Contribute to HIV Persistence During Prolonged Antiretroviral Therapy

Frontiers in Microbiology, 2019
To date, most assays for measuring the human immunodeficiency virus (HIV-1) reservoir do not include memory CD4+ T-cells expressing the activation marker, human leukocyte antigen-antigen D related (HLA-DR).
Eunok Lee, Eunok Lee, Peter Bacchetti, Jeffery Milush, Wei Shao, Eli Boritz, Daniel Douek, Remi Fromentin, Teri Liegler, Rebecca Hoh, Steve G. Deeks, Frederick M. Hecht, Nicolas Chomont, Sarah Palmer, Sarah Palmer   +14 more
doaj   +2 more sources

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease

Nature Communications, 2018
Severe influenza A virus (IAV) infection is associated with immune dysfunction. Here, we show circulating CD8+ T-cell profiles from patients hospitalized with avian H7N9, seasonal IAV, and influenza vaccinees.
Zhongfang Wang, Thi Hoang Oanh Nguyen, Yanmin Wan   +2 more
exaly   +2 more sources

Evaluating the impact of donor eGFR and HLA-DR mismatch on graft survival in living donor kidney transplants [PDF]

Frontiers in Nephrology
BackgroundThis study assesses the impact of human leukocyte antigen (HLA)-DR mismatch and donor-estimated glomerular filtration rate (eGFR) on outcomes of living donor kidney transplantation (LDKT), which are especially relevant to the availability of ...
Pooja Budhiraja, Jesse D. Schold, Jesse D. Schold, Rocio Lopez, Rocio Lopez, Susana Arrigain, Susana Arrigain, Bruce Kaplan, Bruce Kaplan   +8 more
doaj   +2 more sources

Challenges of monocyte HLA-DR targeted immunomodulation in sepsis—a prospective observational cohort study [PDF]

Frontiers in Immunology
IntroductionReduced monocyte HLA-DR expression, a hallmark of immunosuppression in sepsis, is associated with infectious complications and mortality. Therapeutic strategies, including IFN-γ, have been used to restore monocyte HLA-DR and immune function ...
Timothy Arthur Chandos Snow, Antoine Villa, Antonio Cesar, Francis Ryckaert, Naveed Saleem, Deborah Smyth, Holly Pan, Julia Flint, David Brealey, David Brealey, Mervyn Singer, Derek W. Gilroy, Nishkantha Arulkumaran, the University College London Hospitals Critical Care Research Team   +13 more
doaj   +2 more sources

HLA-DR expression in cytotoxic T lymphocytes: a key to boost the therapeutic potential of T cell-based strategies for breast cancer [PDF]

Frontiers in Immunology
T cell-based therapies, involving ex vivo expansion of patients’ T lymphocytes, hold significant promise for chemotherapy resistant cases of breast cancer (BC), although their effectiveness remains challenging.
Rute Salvador, Bruna Filipa Correia, Daniela Grosa, Telma Martins, Telma Martins, Suelen Cristina Soares Baal, Diana Pereira Saraiva, Sofia Cristóvão-Ferreira, Isabel Lopes Pereira, Cátia Rebelo de Almeida, Rita Fior, Antonio Jacinto, Carolina Mathias, Sofia Braga, Sofia Braga, Sofia Braga, M. Guadalupe Cabral   +16 more
doaj   +2 more sources