Memory CD4 + T-Cells Expressing HLA-DR Contribute to HIV Persistence During Prolonged Antiretroviral Therapy [PDF]
Frontiers in Microbiology, 2019 To date, most assays for measuring the human immunodeficiency virus (HIV-1) reservoir do not include memory CD4+ T-cells expressing the activation marker, human leukocyte antigen-antigen D related (HLA-DR).
Eunok Lee +14 more
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Circulating Placental Vesicles Carry HLA-DR in Pre-Eclampsia: A New Potential Marker of the Syndrome [PDF]
Frontiers in Immunology, 2021 BackgroundPre-eclampsia (PE) is a common disorder of pregnancy that usually presents with hypertension and proteinuria. The clinical presentation arises from soluble factors released into the maternal circulation from the placenta owing to the stress of ...
Chiara Tersigni +13 more
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Impaired graft survival in kidney transplants from expanded criteria donors with HLA-DR mismatch [PDF]
Frontiers in TransplantationHuman leukocyte antigen (HLA)-DR mismatches are known to increase the risk of graft rejection following kidney transplantation (KT). Especially in KT using grafts of lower quality from expanded criteria donors (ECD), the immune response plays a critical ...
Uwe Scheuermann +8 more
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Evaluating the impact of donor eGFR and HLA-DR mismatch on graft survival in living donor kidney transplants [PDF]
Frontiers in NephrologyBackgroundThis study assesses the impact of human leukocyte antigen (HLA)-DR mismatch and donor-estimated glomerular filtration rate (eGFR) on outcomes of living donor kidney transplantation (LDKT), which are especially relevant to the availability of ...
Pooja Budhiraja +8 more
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Challenges of monocyte HLA-DR targeted immunomodulation in sepsis—a prospective observational cohort study [PDF]
Frontiers in ImmunologyIntroductionReduced monocyte HLA-DR expression, a hallmark of immunosuppression in sepsis, is associated with infectious complications and mortality. Therapeutic strategies, including IFN-γ, have been used to restore monocyte HLA-DR and immune function ...
Timothy Arthur Chandos Snow +13 more
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HLA-DR expression in cytotoxic T lymphocytes: a key to boost the therapeutic potential of T cell-based strategies for breast cancer [PDF]
Frontiers in ImmunologyT cell-based therapies, involving ex vivo expansion of patients’ T lymphocytes, hold significant promise for chemotherapy resistant cases of breast cancer (BC), although their effectiveness remains challenging.
Rute Salvador +16 more
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Prediction of Potential Drugs Targeting Acute Pancreatitis Based on the HLA-DR-Related Gene-Monocyte Infiltration Regulatory Network [PDF]
Biomedical Engineering and Computational BiologyBackground: Acute pancreatitis (AP) is a common disease of acute abdominal pain, the incidence of which is increasing annually, but its pathogenesis remains incompletely understood.
Wei Xu +5 more
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Increased percentage of HLA-DR T cells in untreated juvenile dermatomyositis [PDF]
Clinical Immunology CommunicationsThis study investigates HLA-DR expression on activated T cells and serum neopterin levels in Juvenile Dermatomyositis (JDM) children pre- and post-treatment. Sixty-nine JDM children (less than 18 years) were included. Elevated HLA-DR+ T cells (>7 %) were
Amer Khojah +6 more
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Spectral cytometry of rheumatoid arthritis patients implicates myeloid dendritic cells and granular HLA-DR+CD15+CD16+ cells in pro-inflammatory antigen presentation [PDF]
Frontiers in ImmunologyIntroductionRheumatoid arthritis (RA) is a systemic autoimmune disease that leads to inflammation of synovial joints and other organs. Many RA patients “share” a common peptide sequence within the HLA-DR (MHC II) molecule expressed on antigen-presenting ...
Christian Geier +5 more
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