Results 11 to 20 of about 125,944 (285)

Monocyte HLA-DR expression in septic shock patients: insights from a 20-year real-world cohort of 1023 cases. [PDF]

open access: hybridIntensive Care Med
Monneret G   +12 more
europepmc   +3 more sources

High percentages of peripheral blood T-cell activation in childhood Hodgkin's lymphoma are associated with inferior outcome

open access: yesFrontiers in Medicine, 2022
The aims of this study were to investigate the activation of T lymphocytes in peripheral blood from children with Hodgkin's lymphoma (HL) and explore their roles for prognosis in HL.
Fengqing Cai   +9 more
doaj   +1 more source

A Multi-Omics Analysis of Metastatic Melanoma Identifies a Germinal Center-Like Tumor Microenvironment in HLA-DR-Positive Tumor Areas

open access: yesFrontiers in Oncology, 2021
The emergence of immune checkpoint inhibitors has dramatically changed the therapeutic landscape for patients with advanced melanoma. However, relatively low response rates and a high incidence of severe immune-related adverse events have prompted the ...
Laura Gadeyne   +18 more
doaj   +1 more source

Antigen presenting subset of СD66b+CD16+CD33+HLA-DR+ neutrophilic granulocytes in acute osteomyelitis in children: Immunomodulating effects of immunotropic hexapeptide in an in vitro experimental system

open access: yesМедицинская иммунология, 2023
Inclusion of neutrophilic granulocytes (NG) in inflammation depends on the expression of receptors providing the functions of NG. Acute osteomyelitis (AOM) occupies a central place among purulentinflammatory diseases in children.
I. V. Nesterova   +5 more
doaj   +1 more source

HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells

open access: yesStem Cells International, 2021
Although human induced pluripotent stem cells (iPSCs) can serve as a universal cell source for regenerative medicine, the use of iPSCs in clinical applications is limited by prohibitive costs and prolonged generation time.
Yoo-Wook Kwon   +10 more
doaj   +1 more source

Imputing Variants in HLA-DR Beta Genes Reveals That HLA-DRB1 Is Solely Associated with Rheumatoid Arthritis and Systemic Lupus Erythematosus. [PDF]

open access: yesPLoS ONE, 2016
The genetic association of HLA-DRB1 with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is well documented, but association with other HLA-DR beta genes (HLA-DRB3, HLA-DRB4 and HLA-DRB5) has not been thoroughly studied, despite their ...
Kwangwoo Kim   +18 more
doaj   +1 more source

Persistent High Percentage of HLA-DR+CD38high CD8+ T Cells Associated With Immune Disorder and Disease Severity of COVID-19

open access: yesFrontiers in Immunology, 2021
BackgroundThe global outbreak of coronavirus disease 2019 (COVID-19) has turned into a worldwide public health crisis and caused more than 100,000,000 severe cases.
Juan Du   +13 more
doaj   +1 more source

Expression of HLA-DR genes in gliomas: correlation with clinicopathological features and prognosis

open access: yesChinese Neurosurgical Journal, 2017
Background Human leukocyte antigen (HLA)-DR is a classical major histocompatibility complex (MHC) class II molecule encoded by five genes: HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4 and HLA-DRB5.
Xing Fan   +5 more
doaj   +1 more source

HLA-DR-Positive NK Cells Expand in Response to Mycobacterium Tuberculosis Antigens and Mediate Mycobacteria-Induced T Cell Activation

open access: yesFrontiers in Immunology, 2021
NK cells play an important role in the control of tuberculosis infection: they are not only able to kill the infected cells, but also control the activity of macrophages and development of the adaptive immune response.
Sofya A. Kust   +7 more
doaj   +1 more source

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