Prediction of Potential Drugs Targeting Acute Pancreatitis Based on the HLA-DR-Related Gene-Monocyte Infiltration Regulatory Network [PDF]
Biomedical Engineering and Computational BiologyBackground: Acute pancreatitis (AP) is a common disease of acute abdominal pain, the incidence of which is increasing annually, but its pathogenesis remains incompletely understood.
Wei Xu +5 more
doaj +2 more sources
Increased percentage of HLA-DR T cells in untreated juvenile dermatomyositis [PDF]
Clinical Immunology CommunicationsThis study investigates HLA-DR expression on activated T cells and serum neopterin levels in Juvenile Dermatomyositis (JDM) children pre- and post-treatment. Sixty-nine JDM children (less than 18 years) were included. Elevated HLA-DR+ T cells (>7 %) were
Amer Khojah +6 more
doaj +2 more sources
Potential role for HIV-specific CD38-/HLA-DR+ CD8+ T cells in viral suppression and cytotoxicity in HIV controllers. [PDF]
PLoS ONE, 2014 BACKGROUND:HIV controllers (HIC) are rare HIV-1-infected patients who exhibit spontaneous viral control. HIC have high frequency of CD38-/HLA-DR+ HIV-specific CD8+ T cells. Here we examined the role of this subset in HIC status.
Stéphane Hua +10 more
doaj +2 more sources
Spectral cytometry of rheumatoid arthritis patients implicates myeloid dendritic cells and granular HLA-DR+CD15+CD16+ cells in pro-inflammatory antigen presentation [PDF]
Frontiers in ImmunologyIntroductionRheumatoid arthritis (RA) is a systemic autoimmune disease that leads to inflammation of synovial joints and other organs. Many RA patients “share” a common peptide sequence within the HLA-DR (MHC II) molecule expressed on antigen-presenting ...
Christian Geier +5 more
doaj +2 more sources
IL-15-Activated CD38+HLA-DR+CD8+ T cells induce liver injury in cirrhosis via JAK/STAT5 and PI3K/mTOR pathways [PDF]
Scientific ReportsThe development and progression of liver cirrhosis are considerably influenced by immune processes, with CD8 + T cells playing a key role. Notably, cytokines can activate bystander CD38 + HLA-DR + CD8 + T cells without the need for T cell receptor (TCR ...
Ke Liu +6 more
doaj +2 more sources
HLA-DR and -DQ Eplet Mismatches and Transplant Glomerulopathy: A Nested Case–Control Study
American Journal of Transplantation, 2015 R. Sapir-Pichhadze +13 more
exaly +2 more sources
HLA-DR Marks Recently Divided Antigen-Specific Effector CD4 T Cells in Active Tuberculosis Patients
Journal of Immunology, 2021 Upon Ag encounter, T cells can rapidly divide and form an effector population, which plays an important role in fighting acute infections. In humans, little is known about the molecular markers that distinguish such effector cells from other T cell ...
R. Tippalagama +20 more
semanticscholar +1 more source