Results 241 to 250 of about 114,761 (352)

Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8+ T Cell Clones

open access: yesArthritis &Rheumatology, Volume 78, Issue 1, Page 152-165, January 2026.
Objective Psoriatic arthritis (PsA) is an HLA class I–associated inflammatory arthritis that develops in up to 30% of people with psoriasis. We tested the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8+ T cell phenotype and clonality.
Lucy E. Durham   +14 more
wiley   +1 more source

Myeloid-T cell proximity is prominent in healthy pregnancies with extreme fetal-maternal HLA incompatibility. [PDF]

open access: yesiScience
Tian X   +14 more
europepmc   +1 more source

A Tolerogenic Plasmid Inhibits Autoantibody Production Triggered by Immunization With Human Peptidyl Arginine Deiminase 4

open access: yesArthritis &Rheumatology, Volume 78, Issue 1, Page 80-89, January 2026.
Objective Rheumatoid arthritis (RA) is usually preceded and likely mediated by autoantibodies to citrullinated proteins (ACPAs) that recognize citrulline residues on multiple proteins. Conversion of arginine into citrulline is performed by enzymes called peptidyl arginine deiminases (PADs). We have previously demonstrated that the human PAD4 (hPAD4) is
Philippe P. Pagni   +10 more
wiley   +1 more source

Preclinical development of an mRNA-based multiepitope immunotherapeutic for glioblastoma. [PDF]

open access: yesCancer Immunol Immunother
Lutz J   +8 more
europepmc   +1 more source

Comparative Effectiveness of Abatacept Versus Adalimumab in Shared Epitope Positive and Negative Patients With Rheumatoid Arthritis

open access: yesArthritis &Rheumatology, Volume 78, Issue 1, Page 59-67, January 2026.
Objective The effect of the shared epitope (SE) and valine at position 11 (Val11) of HLA–DRB1 on the activation of CD4+ T cells is expected to be diminished by abatacept, a costimulation blocker. However, published evidence on the value of genetic stratification for abatacept treatment is conflicting. We aimed to compare the difference in effectiveness
Chuan Fu Yap   +14 more
wiley   +1 more source

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