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SARS-CoV-2 infection induces adaptive NK cell responses by spike protein-mediated induction of HLA-E expression. [PDF]

Emerg Microbes Infect
Hasan MZ, Claus M, Krüger N, Reusing S, Gall E, Bade-Döding C, Braun A, Watzl C, Uhrberg M, Walter L.   +9 more
europepmc   +1 more source

Obtaining Gene-Modified HLA-E-Expressing Feeder Cells for Stimulation of Natural Killer Cells. [PDF]

Pharmaceutics
Alekseeva NA, Streltsova MA, Vavilova JD, Ustiuzhanina MO, Palamarchuk AI, Boyko AA, Timofeev ND, Popodko AI, Kovalenko EI.   +8 more
europepmc   +1 more source

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HLA‐E and immunobiology of pregnancy

Tissue Antigens, 2006
AbstractRecently, it has been suggested that non‐classical antigens such as human leukocyte antigen (HLA)‐G and HLA‐E may interact with KIR receptors of NK cells which results into downregulation of immune response and helps in the maintenance of pregnancy.
P, Tripathi, S, Naik, S, Agrawal
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Molecular Typing of HLA-E

2012
Human leukocyte antigen-E (HLA-E) is a non-classical HLA class I gene that shows a limited degree of polymorphism compared to the classical HLA genes. The HLA-E molecule can bind peptides derived from the leader sequence of various HLA class I alleles and some viral homologues, including CMV.
Nina, Lauterbach, Christina E M, Voorter, Marcel G J, Tilanus   +2 more
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HLA-E and HLA-E-Bound Peptides: Recognition by Subsets of NK and T Cells

Current Pharmaceutical Design, 2009
In humans, major histocompatibility complex (MHC) class I molecules comprise the classical (class Ia) human leukocyte antigens (HLA)-A, -B, and -C, and the non-classical (class Ib) HLA-E, -F, -G and -H (HFE) molecules. The best-characterized MHC class Ib molecule is HLA-E. HLA-E was first described as a non-polymorphic ligand of the CD94/NKG2 receptors
PIETRA, GABRIELLA, Romagnani C, MORETTA, LORENZO, MINGARI, MARIA CRISTINA   +3 more
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Peptide‐induced HLA‐E expression in human PBMCs is dependent on peptide sequence and the HLA‐E genotype

Tissue Antigens, 2015
AbstractHuman Leukocyte Antigen (HLA)‐E is a low‐polymorphic non‐classical HLA class I molecule which plays a crucial role in immune surveillance by presentation of peptides to T and natural killer (NK) cells. HLA‐E polymorphism is related to HLA‐E surface expression and is associated with patient outcome after stem cell transplantation.
Lauterbach, N., Wieten, L., Popeijus, H.E., Vanderlocht, J., van Zon, P.M., Voorter, C.E., Tilanus, M G.   +6 more
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Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer

Annals of Surgical Oncology, 2022
Some reports showed the immune tolerance of soluble human leukocyte antigen E (HLA-E), but the role that soluble HLA-E plays in gastric cancer (GC) is unknown. We aimed to clarify the molecular mechanism and clinical significance of soluble HLA-E in GC.We examined the expression of HLA-E on GC cells and soluble HLA-E under co-culture with natural ...
Takeshi, Morinaga, Masaaki, Iwatsuki, Kohei, Yamashita, Noriko, Yasuda-Yoshihara, Taishi, Yamane, Chihiro, Matsumoto, Kazuto, Harada, Kojiro, Eto, Junji, Kurashige, Takatsugu, Ishimoto, Yoshifumi, Baba, Yuji, Miyamoto, Naoya, Yoshida, Hideo, Baba   +13 more
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Analysis of HLA-E expression in human tumors

Immunogenetics, 2003
Downregulation of MHC class Ia molecule expression is a widespread mechanism used by tumor cells to escape antitumor T-cell-mediated immune responses. However, it is not known why NK cells cannot lyse these MHC class-Ia-deficient tumor targets. Tumors must select additional routes of escape from NK cells.
Rosario, Marín, Francisco, Ruiz-Cabello, Susana, Pedrinaci, Rosa, Méndez, Pilar, Jiménez, Daniel E, Geraghty, Federico, Garrido   +6 more
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HLA‐E polymorphism in patients with nasopharyngeal carcinoma

Tissue Antigens, 2004
Abstract:  Nasopharyngeal carcinoma (NPC) has been known to be associated with HLA class I region. The aim of this study was to investigate the association between HLA‐E and genetic susceptibility to nasopharyngeal carcinogenesis by comparing the frequencies of HLA‐E alleles in 100 Thai NPC patients and 100 healthy controls.
N, Hirankarn, I, Kimkong, A, Mutirangura
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Involvement of position-147 for HLA-E expression

Biochemical and Biophysical Research Communications, 2006
HLA-E functions as an inhibitory signaling molecule of natural killer (NK) cell-mediated cytolysis. However, the cell surface expression of HLA-E molecules is quite restricted because of the limited repertoire of binding peptide sequences, such as signal peptides of other HLA molecules, especially on xenogeneic cells.
Katsuyoshi, Matsunami, Tamiko, Kusama, Eiji, Okura, Ryota, Shirakura, Masahiro, Fukuzawa, Shuji, Miyagawa   +5 more
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