HLA-G Expression Is an Independent Predictor for Improved Survival in High Grade Ovarian Carcinomas
Journal of Immunology Research, 2014 Aberrant expression of human leukocyte antigens (HLA) class I has prognostic importance in various cancers. Here, we evaluated the prognostic value of classical (A/B/C) and nonclassical (G/E) HLA expression in 169 high grade epithelial ovarian cancer ...
M. J. Rutten +6 more
doaj +1 more source
Controlling the immunological crosstalk during conception and pregnancy: HLA-G in reproduction
Frontiers in Immunology, 2014 In several years after its discovery in the placenta, the Human Leukocyte Antigen (HLA) class Ib protein, HLA-G, was not given much attention, nor was it assigned great importance. As time has unraveled, HLA-G has proven to have distinctive functions and
Line eLynge Nilsson +2 more
doaj +1 more source
Integrins and adhesion molecules: Gelatinase and oncofetal fibronectin secretion is dependent on integrin expression on human cytotrophoblasts [PDF]
, 2017 Collagenolytic activity of cytotrophoblasts is stimulated by glycoproteins of the extracellular matrix and since this stimulation can possibly occur through integrins, we measured the gelatinolytic activity of villous and extravillous cytotrophoblasts ...
Bischof, P., Campana, A., Haenggeli, L.
core
Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies. [PDF]
, 2015 Treatment of hematological malignant disorders has been improved over the last years, but high relapse rate mainly attributable to the presence of minimal residual disease still persists.
Biassoni +67 more
core +1 more source
Advanced Science, EarlyView.IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang +15 more
wiley +1 more source
The Dual Role of HLA-G in Cancer
Journal of Immunology Research, 2014 We here review the current data on the role of HLA-G in cancer based on recent findings of an unexpected antitumor activity of HLA-G in hematological malignancies.
Nathalie Rouas-Freiss +3 more
doaj +1 more source
Structural and Functional Basis for LILRB Immune Checkpoint Receptor Recognition of HLA-G Isoforms
Journal of Immunology, 2019 Key Points The β2m-free HLA-G1 isoform tends to dimerize and further multimerize. The β2m-free HLA-G1 isoform specifically binds to LILRB2 with avidity effects. The crystal structure of LILRB1/HLA-G1 complex showed a flexible binding manner.
K. Kuroki +14 more
semanticscholar +1 more source
Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10. [PDF]
, 1996 The mechanism by which the mammalian mother accepts the implanting fetus as an allograft remains unexplained, but is likely to be the result of a combination of factors.
Abrams, JS +5 more
core +1 more source
Advanced Science, EarlyView.This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li +12 more
wiley +1 more source
Enhancing Natural Killer and CD8 + T Cell-Mediated Anticancer Cytotoxicity and Proliferation of CD8 + T Cells with HLA-E Monospecific Monoclonal Antibodies [PDF]
, 2019 Cytotoxic NK/CD8+ T cells interact with MHC-I ligands on tumor cells through either activating or inhibiting receptors. One of the inhibitory receptors is CD94/NKG2A.
Asgharzadeh, Shahab +3 more
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