Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection [PDF]
, 2020 The development of autoimmune disorders is incompletely understood. Inefficient thymic T cell selection against self-peptides presented by major histocompatibility antigens (HLA in humans) may contribute to the emergence of auto-reactive effector cells ...
Loll, Bernhard +3 more
core +1 more source
GUT MICROBIOTA EFFECTS IN HEMATOPOIETIC STEM CELL TRANSPLANT PATIENTS
İstanbul Tıp Fakültesi Dergisi, 2022 Objective: In our study, we analyzed gut microbiota in allo-HSCT patients and aimed to evaluate the relationship of gut microbiota with transplant complications, mainly GVHD.
Ekin Ece Gürer Kluge +6 more
doaj +1 more source
Impaired Intracellular Transport and Cell Surface Expression of Nonpolymorphic HLA-E [PDF]
, 1992 The assembly of the classical, polymorphic major histocompatibility complex class I molecules in the endoplasmic reticulum requires the presence of peptide ligands and ~2-microglobulin (~2m). Formation of this trimolecular complex is a prerequisite for e~
Johnson, Judith P. +3 more
core +1 more source
Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles [PDF]
, 1989 Several new HLA-B (B8, B51, Bw62)- and HLA-C (Cw6, Cw7)-specific genes were isolated either as genomic cosmid or cDNA clones to study the diversity of HLA antigens.
Doerner, C. +4 more
core +1 more source
HLA-DP, HLA-DQ, and HLA-DR Have Different Requirements for Invariant Chain and HLA-DM [PDF]
Journal of Biological Chemistry, 2010 The MHC is central to the adaptive immune response. The human MHC class II is encoded by three different isotypes, HLA-DR, -DQ, and -DP, each being highly polymorphic. In contrast to HLA-DR, the intracellular assembly and trafficking of HLA-DP molecules have not been studied extensively.
Marcel, van Lith +2 more
openaire +2 more sources
Arthroscopic Treatment of a Malunion of a Posteromedial Tubercle Fracture of the Talus
Arthroscopy Techniques, 2017 Posteromedial ankle impingement is rare and uncommonly associated with a fracture. Bone resection of the fragment is the recommended treatment. In this report, we describe the step-by-step surgical technique of arthroscopic resection of a malunion of a ...
Jesús Más Martínez, M.D. +5 more
doaj +1 more source
Association of HLA class II alleles with suicidal behavior in a Transylvanian population
Romanian Journal of Laboratory Medicine, 2023 Background: Suicide is a complex phenomenon determined by the interaction of various risk factors. The Major Histocompatibility Complex is the most polymorphic gene cluster of the entire human genome, being linked to both the regulation of the immune ...
Vuscan Mihaela Elvira +7 more
doaj +1 more source
HLA diversity in the Russian population assessed by next generation sequencing
Медицинская иммунология, 2021 Next generation sequencing is used to determine full-length sequences of HLA genes at the 4-field (allelic) resolution. The study was aimed at determining frequency and diversity of HLA alleles in a cohort of blood donors from the Registry of the ...
E. G. Khamaganova +5 more
doaj +1 more source
The HLA-E Gene encodes two differentially regulated Transcripts and a Cell Surface Protein [PDF]
, 1992 An HLA-E-specific oligonucleotide probe was used to study the expressioonf HLA-E. This probed etects two HLA-E transcripts, 1.8 and 2.7 kb in size, which are present in varying ratios in allt issues and cell lines investigated.
Honka, Thomas +4 more
core +1 more source
Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6 [PDF]
, 1989 Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the c~-helical region of the c~ 1 domain flanked by the amino acid ...
Engler-Blum, G. +5 more
core +1 more source