Results 41 to 50 of about 589,195 (286)

HLA-B27

Annual Review of Immunology, 2015
Possession of the human leukocyte antigen (HLA) class I molecule B27 is strongly associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 is unknown. Two broad theories most likely explain the role of HLA-B27 in AS pathogenesis. The first is based on the natural immunological function of HLA-B27 of presenting antigenic peptides ...
openaire   +2 more sources

Non-invasive comparative study of HLA genotyping between urinary and blood DNA using sequencing-based typing and third-generation sequencing

Advances in Laboratory Medicine
To evaluate the feasibility of urinary DNA as a noninvasive alternative for high-resolution HLA genotyping and validate its concordance with conventional blood-based methods.
Fan Cheng Yan, Wen Yu Jie, Li Dong Mei, Jing Yuan Yuan, Liu Na, Wang Jie, Wang Li Jun, Lian Xue, Jia Yan Jun, Sun Tie Cheng   +9 more
doaj   +1 more source

The Humoral Theory of Transplantation: Epitope Analysis and the Pathogenicity of HLA Antibodies. [PDF]

, 2016
Central to the humoral theory of transplantation is production of antibodies by the recipient against mismatched HLA antigens in the donor organ. Not all mismatches result in antibody production, however, and not all antibodies are pathogenic.
Farber, John, Filippone, Edward J
core   +4 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus Immunoevasion. [PDF]

, 2013
Control of human cytomegalovirus (HCMV) depends on CD8+ T cell responses that are shaped by an individual's repertoire of MHC molecules. MHC class I presentation is modulated by a set of HCMV-encoded proteins.
Ameres, Stefanie, Busch, Dirk H., Mautner, Josef, Moosmann, Andreas, Neuenhahn, Michael, Plachter, Bodo, Schlott, Fabian   +6 more
core   +7 more sources

Dysphonia of exceptional origin: lichen planus of the vocal fold — a case report of a very uncommon area affected by lichen planus

The Egyptian Journal of Otolaryngology, 2022
Background Lichen planus is an immune-mediated chronic inflammatory condition of unknown origin that affects the skin and the mucosa. Lichen planus in the larynx is not common, and there are few cases reported in literature.
Gisela Risson Pino, Irene Rodríguez Pérez, Beatriz Bhathal Guede, José Granell Navarro   +3 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Epidemiology and immunogenetic background of islet cell antibody - positive nondiabetic schoolchildren : Ulm-Frankfurt population study [PDF]

, 1991
Islet cell antibodies (ICAs) were determined in a large cohort of white nondiabetic schoolchildren (n = 4287) from a homogenous population in southern Germany.
Böhm, Bernhard Otto, Glück, Michael, Holzberger, G., Kühnl, Peter, Manfras, Burkhard J., Scherbaum, Werner A., Schöffling, Karl, Seidl, S., Seißler, Jochen, Trucco, Massimo   +9 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

L´association entre les gènes HLA II et la susceptibilité à l´asthme chez une population Constantinoise sélectionnée

The Pan African Medical Journal, 2020
INTRODUCTION: L´asthme est une maladie complexe causé par l´interaction de plusieurs gènes dont certains ont un effet protecteur et d´autres contribuent à l´apparition de la maladie.
Dahbia Ines Dahmani, Nacima Chila, Fouzia Abdelouahab, Houda Bouyoucef, Mohamed Bougrida, Laila Rouabah, Fayssal Nedjar   +6 more
doaj   +1 more source