Current Issues in Molecular Biology, 2022 Background: Genetic susceptibility to infectious diseases is partly due to the variation in the human genome, and COVID-19 is not the exception. This study aimed to identify whether risk alleles of known genes linked with emphysema (SERPINA1) and ...
Salvador García-Carmona +16 more
doaj +1 more source
TripHLApan: predicting HLA molecules binding peptides based on triple coding matrix and transfer learning [PDF]
arXiv, 2022 Human leukocyte antigen (HLA) is an important molecule family in the field of human immunity, which recognizes foreign threats and triggers immune responses by presenting peptides to T cells. In recent years, the synthesis of tumor vaccines to induce specific immune responses has become the forefront of cancer treatment.
arxiv
Integrate CRISPR/Cas9 for protein expression of HLA-B*38:68Q via precise gene editing. [PDF]
, 2019 The determination of null- or low-expressed HLA alleles is clinically relevant in both hematopoietic stem cell transplantation and solid organ transplantation.
Reed, Elaine F +2 more
core
E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain via its first hydrophobic domai [PDF]
, 2006 Human papillomavirus type 16 E5 protein (HPV-16 E5) is expressed early in papillomavirus infection and is localised primarily in the cell Golgi apparatus (GA) and endoplasmic reticulum. E5 prevents transport of the major histocompatibility class I (MHC I;
Adam +30 more
core +1 more source
Pharmacogenetics Approach for the Improvement of COVID-19 Treatment
Viruses, 2021 The treatment of coronavirus disease 2019 (COVID-19) has been a challenge. The efficacy of several drugs has been evaluated and variability in drug response has been observed.
Ingrid Fricke-Galindo +1 more
doaj +1 more source
Factors influencing transfusion-associated HLA sensitization in patients bridged to heart transplantation using ventricular assist device. [PDF]
, 2020 BackgroundBridging heart failure patients with mechanical ventricular assist devices (VAD) enables access to transplantation. However, VAD is associated with increased risk for anti-HLA antibodies associated with rejection of subsequent allografts ...
Adler, Eric +5 more
core +1 more source
Predicting Kidney Transplant Survival using Multiple Feature Representations for HLAs [PDF]
Proceedings of the 19th International Conference on Artificial
Intelligence in Medicine (2021) 51-60, 2021 Kidney transplantation can significantly enhance living standards for people suffering from end-stage renal disease. A significant factor that affects graft survival time (the time until the transplant fails and the patient requires another transplant) for kidney transplantation is the compatibility of the Human Leukocyte Antigens (HLAs) between the ...
arxiv
HLA predictions from long sequence read alignments, streamed directly into HLAminer [PDF]
arXiv, 2022 The rapidly changing landscape of sequencing technologies brings new opportunities to genomics research. Longer sequence reads and higher sequence throughput coupled with ever-improving base accuracy and decreasing per-base cost is now making long reads suitable for analyzing polymorphic regions of the human genome, such as those of the human leucocyte
arxiv
The Surface Deformation and Earthquake History Associated with the 1975 M 6.8 Bagan Earthquake in Myanmar [PDF]
, 2020 The 1975 M 6.8 Bagan earthquake occurred on 8th July 1975, at 12:04:38 (UTC). The epicenter was at 21.50N 94.70E with the depth of 112 km (ISC) and focal mechanism is thrusting (USGS). The intensity of earthquake was severe which involved ...
Aung, Hla Hla
core +1 more source
Revista Paraguaya de Reumatología, 2021 Introducción: La enfermedad de Vogt-Koyanagi-Harada (VKH) es de etiología autoinmune y severa, se manifiesta con panuveítis bilateral y puede afectar sistema neuroauditivo y piel. La influencia de los factores genéticos en la expresión de VKH, ha quedado
Nelly Colmán +7 more
doaj +1 more source