Results 61 to 70 of about 313,560 (297)

Clinical, bio­chemical and genetic characteristics of familial forms of type 1 diabetes

Сахарный диабет
BACKGROUND: Familial clustering of type 1 diabetes (T1D) highlights the importance of genetic and environmental factors in the pathophysiology of diabetes mellitus (DM).
I. M. Zufarova, D. N. Laptev, I. R. Minniahmetov, R. I. Khusainova, S. V. Popov, E. V. Titovich, I. A. Eremina, V. A. Peterkova   +7 more
doaj   +1 more source

CellPhenoX: An Explainable Machine Learning Method for Identifying Cell Phenotypes To Predict Clinical Outcomes from Single‐Cell Multi‐Omics

Advanced Science, EarlyView.
CellPhenoX is an explainable machine learning framework that identifies cell‐specific phenotypes and interaction effects from single‐cell omics data. By leveraging interpretable models, it enables robust discovery of cell‐level phenotypes that contribute to clinical outcomes.
Jade Young, Jun Inamo, Zachary Caterer, Revanth Krishna, Fan Zhang   +4 more
wiley   +1 more source

Estudio de una población barranquillera basada en los alelos DRB1 y DQB1 comparada con otras poblaciones suramericanas

Revista Alergia México, 2018
Antecedentes: Todavía se desconoce el origen del poblamiento americano, pero con el tiempo se han desarrollado diversas teorías al respecto. Colombia fue un importante vínculo entre los hemisferios Norte y el Sur del continente americano.
Carlos Hernando-Parga
doaj  

Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution

Advanced Science, EarlyView.
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao, Pingying Qing, Hanxiao Chen, Zhengyan Hu, Qiaoran Yang, Chenyang Lu, Huimin Liu, Rujun Zeng, Yuanting Tang, Fan Yu, Jinbiao Han, Xin Liao, Xun Zeng, Lang Qin   +13 more
wiley   +1 more source

Vitiligo Signature‐Based Drug Screening Identifies Fulvestrant as a Novel Immunotherapy Combination Strategy

Advanced Science, EarlyView.
A vitiligo‐derived gene signature predicts response to immune checkpoint blockade across multiple cancer cohorts, providing a framework for patient stratification. Building on this, Fulvestrant—a clinically approved estrogen receptor degrader—further enhances antitumor immunity by reprogramming tumor‐associated macrophages and promoting CD8⁺ T cell ...
Jie Zhu, Liting Huang, Suzhen Bi, WeiKaixin Kong, Wanting Feng, Yingjia Li, Zhengwei Xie, Peipei Shan, Sujie Zhu   +8 more
wiley   +1 more source

CIITA-related block of HLA class II expression, upregulation of HLA class I, and heterogeneous expression of immune checkpoints in hepatocarcinomas: implications for new therapeutic approaches

OncoImmunology, 2019
Hepatocellular carcinoma (HCC) is the second cause of death for cancer worldwide, justifying the urgent need for novel therapeutic approaches. Immunotherapeutic strategies based on triggering and/or rescuing tumor antigen-specific T cells may be ...
Elise Ramia, Anna Maria Chiaravalli, Farah Bou Nasser Eddine, Alessandra Tedeschi, Fausto Sessa, Roberto S. Accolla, Greta Forlani   +6 more
doaj   +1 more source

A Serum‐Stable Antimicrobial Peptide‐Based Delivery Platform for Selective Treatment of Nontargetable and Chemoresistant Tumors

Advanced Science, EarlyView.
A modular antimicrobial‐peptide‐based therapeutic system integrating membrane‐targeted selectivity, a conformation‐driven polyethylene glycolylated blocker, and serum‐stabilizing N‐cap is developed. The optimized conjugate 270 shows potent, rapid killing of the desired tumor cells, high serum stability, low off‐target toxicity, and broad applicability,
Tianxing Liu, Lingyu Ke, Ruize Sun, Xiaoling Chen, Mei Zhou, Olaf R. P. Bininda‐Emond, Chengbang Ma, Yangyang Jiang, Tao Wang, Chris Shaw, Lei Wang, Tianbao Chen, Alideertu Dong   +12 more
wiley   +1 more source

Inmunogenética e inmunopatología de la diabetes insulinodependiente tipo I

Salud Uninorte, 2005
La diabetes insulinodependiente tipo I (T1D) es una enfermedad crónica y autoinmune que altera la calidad de vida en niños desde muy temprana edad. Esta patología genera un alto costo para la salud pública y produce trastornos psicoafectivos en el ...
Gloria Garavito, Kelly Del Toro, Eduardo Egea B, Eduardo Enrique Egea, Elkin Navarro   +4 more
doaj  

Human histocompatibility determinants and virus antigens: effect of measles virus infection on HLA expression. [PDF]

, 1977
Martin V. Haspel, M. A. Pellegrino, Peter W. Lampert, M B Oldstone   +3 more
openalex   +1 more source

Single‐Cell Transcriptome Profiling Reveals Conserved IFNγ‐IL8 Signaling‐Induced Antibacterial Neutrophil States during Bacterial Infection

Advanced Science, EarlyView.
SummaryThis study constructs a single‐cell immune atlas of Nile tilapia across multiple time points during Streptococcus agalactiae infection, revealing dynamic immune cell responses and subtype transitions. It identifies a conserved IFNr‐STAT1‐IL8 axis driving il8+ neutrophils activation and antibacterial function, supported by cross‐species ...
Xue Zhai, Minghao Zhang, Kang Li, Wei Li, Xiaolong Li, Wa Gao, Zhaosheng Sun, Dan Huang, Songqian Huang, Mingli Liu, Zhichao Wu, Jun Zou, Liangbiao Chen, Jialong Yang, Peng Hu   +14 more
wiley   +1 more source