Results 101 to 110 of about 13,841,936 (288)

Human Leukocyte Antigen Typing Using a Knowledge Base Coupled with a High Throughput Oligonucleotide Probe Array Analysis

open access: yesFrontiers in Immunology, 2014
Human leukocyte antigens (HLA) are important biomarkers since multiple diseases, drug toxicity, and vaccine responses reveal strong HLA associations. Current clinical HLA typing is an elimination process requiring serial testing.
Vladimir eBrusic, Vladimir eBrusic
doaj   +1 more source

25 years of the IPD‐IMGT/HLA Database

open access: yesHLA
Twenty‐five years ago, in 1998, the HLA Informatics Group of the Anthony Nolan Research Institute released the IMGT/HLA Database. Since this time, this online resource has acted as the repository for the numerous variant sequences of HLA alleles named by
James Robinson   +2 more
semanticscholar   +1 more source

Molecular MRI Reveals Macrophage‐Enriched Peritumoral Immune Remodeling After Incomplete Ablation in Liver Cancer

open access: yesAdvanced Science, EarlyView.
Incomplete microwave ablation (iMWA) induced a spatially organized, macrophage‐rich immunosuppressive tumor microenvironment (TME) in orthotopic VX2 liver tumors. Molecular MRI enhanced with europium‐doped very small superparamagnetic iron oxide nanoparticles (Eu‐VSOP) noninvasively visualized this remodeling, showing preferential nanoparticle ...
Yubei He   +22 more
wiley   +1 more source

HLAreporter: a tool for HLA typing from next generation sequencing data

open access: yesGenome Medicine, 2015
Human leukocyte antigen (HLA) typing from next generation sequencing (NGS) data has the potential for widespread applications. Here we introduce a novel tool (HLAreporter) for HLA typing from NGS data based on read-mapping using a comprehensive reference
Ya-Zhi Huang   +8 more
semanticscholar   +1 more source

Fine‐scale genetic structure of the cloud forest tree Ocotea psychotrioides revealed by genome‐wide SNP data

open access: yesAmerican Journal of Botany, EarlyView.
Abstract Premise Recent advances in genomic technologies now enable the reconstruction of evolutionary histories at fine spatial scales, illuminating the complex dynamics that shape biodiversity patterns in naturally discontinuous, archipelago‐like ecosystems such as cloud forests.
Leopoldo Hurtado‐Reveles   +4 more
wiley   +1 more source

AMBIGUITY OF LOCI DURING HLA-TYPING ON SSO TECHNOLOGY AND ATTEMPT TO RESOLVE THEM

open access: yesВестник трансплантологии и искусственных органов, 2010
Sequence specific oligonucleotides typing was used to identify human leukocyte antigen (HLA)-A, B, DRB1 alleles from 705 recruited volunteers with Volga Federal District for unrelated hematopoietic stem cell registry and 155 of their number at locus HLA ...
M. A. Loginova   +2 more
doaj   +1 more source

Development of a high-resolution NGS-based HLA-typing and analysis pipeline

open access: yesNucleic Acids Research, 2015
The human leukocyte antigen (HLA) complex contains the most polymorphic genes in the human genome. The classical HLA class I and II genes define the specificity of adaptive immune responses.
Michael Wittig   +13 more
semanticscholar   +1 more source

Distinct Consequences of BCOR and BCORL1 Mutations in Myeloid Neoplasms and Bone Marrow Failure

open access: yesAmerican Journal of Hematology, EarlyView.
ABSTRACT BCOR and BCORL1 (BCOR/L1) mutations are observed in both myeloid neoplasms (MN) and bone marrow failure syndromes (BMF), but their clinical significance may differ. We analyzed 11 340 patients and identified 418 BCOR/L1‐mutated patients, focusing on differences between MN and BMF. Compared with MN, BMF was associated with younger age, a higher
Atsushi Marumo   +23 more
wiley   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

open access: yesAdvanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang   +12 more
wiley   +1 more source

HLA-C and HLA-DQB1 compatibility in unrelated cord blood transplants

open access: yesHaematologica, 1999
BACKGROUND AND OBJECTIVE: Umbilical cord blood (UCB) cells have been definitively proved to be a source of hematopoietic stem cells with repopulating capacity when transplanted into pediatric hosts with neoplastic or non-neoplastic disease. Moreover, due
L Elia   +9 more
doaj  

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