Results 101 to 110 of about 71,842 (286)

Protection by 20-5,14-HEDGE Against Surgically-Induced Ischemia Reperfusion Lung Injury in Rats [PDF]

, 2012
Background We previously reported that the cytochrome P450 product 20-hydroxyeicosatetraenoic acid has prosurvival effects in pulmonary artery endothelial cells and ex vivo pulmonary arteries.
Ali, Irshad, Clough, Anne V., Falck, John R., Gao, Ying, Gruenloh, Stephanie, Jacobs, Elizabeth R., Medhora, Meetha   +6 more
core   +2 more sources

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Role of HMGB1 in Vitiligo: Current Perceptions and Future Perspectives

Clinical, Cosmetic and Investigational Dermatology, 2022
Guangmin Wei,1 Yinghao Pan,2 Jingying Wang,2 Xia Xiong,2 Yuanmin He,2 Jixiang Xu2 1Department of Dermatology, Medical Center Hospital of Qionglai City, Qionglai, Sichuan, People’s Republic of China; 2Department of Dermatology, The Affiliated Hospital of ...
Wei G, Pan Y, Wang J, Xiong X, He Y, Xu J   +5 more
doaj  

HMGB1 as a representative DAMP and anti-HMGB1 antibody therapy

Folia Pharmacologica Japonica, 2018
High mobility group box-1 (HMGB1), a representative damage-associated molecular patterns (DAMPs), has been reported to be involved in many inflammatory diseases. To validate HMGB1 as a target molecule of inflammatory diseases and to examine the effects of inhibition of HMGB1 on the diseases, we raised anti-HMGB1 monoclonal antibody (mAb) neutralizing ...
openaire   +3 more sources

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

HMGB1’in Kanser ve Tedavisiyle İlişkisi

Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2019
Yüksek mobilite grup kutusu 1 (HMGB1)histon olmayan DNA proteini olup, kısaca DAMP olarak ifade edilen(Damage-associated molecular pattern) tehlike sinyali veya alarmı olarak görevyapar.
Celal Güven, Eylem Taşkın Güven, Salih Tunç Kaya, Yusuf Sevgiler   +3 more
doaj   +1 more source

Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype [PDF]

, 2016
BACKGROUND AND AIMS: Colorectal cancer (CRC) arises via multiple genetic changes. Mutation of the tumour suppressor gene APC, a key regulator of Wnt signalling, is recognised as a frequent early driving mutation in CRC.
Antoine, Bachi, Clarke, Clarke, Clevers, Coppola, Coyle, Dale, Fodde, Jenkins, Jin, Kang, Kim, Lee, Liu, Lotze, McCormick, Nieto, Omata, Pasheva, Pastorino, Plevy, Rauvala, Rauvala, Rubartelli, Scheiflinger, Schwabe, Tang, Tracey, Tracey, van den Brink, Wilson, Winton   +32 more
core   +4 more sources

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Increased HMGB1 expression and release by mononuclear cells following surgical/anesthesia trauma [PDF]

, 2010
Introduction: High mobility group box 1 (HMGB1) is a key mediator of inflammation that is actively secreted by macrophages and/or passively released from damaged cells.
Valeria Manganelli, Michele Signore, Ilaria Pacini, Roberta Misasi, Guglielmo Tellan, Tina Garofalo, Emanuela Lococo, Piero Chirletti, Maurizio Sorice, Giovanna Delogu   +9 more
core   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source