Results 121 to 130 of about 51,717 (306)

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Associations of HMGB1, sTNFR-1 and NLR with Premature Delivery Secondary to Infection in Pregnant Women Undergoing Cervical Cerclage

Clinical and Experimental Obstetrics & Gynecology
Background: Although cervical cerclage has improved with the rapid development of medical technology, there remains a distinct probability of adverse pregnancy outcomes.
Shengnan Cai, Yanting Wu, Yiqian Ding, Li Zeng   +3 more
doaj   +1 more source

MiR-204-5p inhibits proliferation, invasion and migration of thyroid papillary carcinoma K1 cells in vitro by targeting HMGB1 gene

Di-san junyi daxue xuebao, 2019
Objective To investigate the effects of miR-204-5p on the proliferation, invasion and migration of thyroid papillary carcinoma K1 cells and its mechanism.
HAO Junjian, HAO Lijuan
doaj   +1 more source

High-Mobility Group Box 1-Mediated Matrix Metalloproteinase-9 Expression in Non-Small Cell Lung Cancer Contributes to Tumor Cell Invasiveness

, 2011
High-mobility group box 1 (HMGB1) is a versatile protein with intranuclear and extracellular functions. It is involved in invasion and metastasis in various human malignancies.
LIU, PO-LEN;CHOU, SHAH-HWA;LIN, FENG-YEN;CHEN, YUH-LIEN;CHEN, WEN-CHI;CHEN, YUNG-HSIANG;CHONG, INN-WEN, 劉博侖;周世華;林豐彥;陳玉怜;陳汶吉;陳永祥;鍾飲文   +1 more
core  

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

The Association Between Serum HMGB2 Levels and Abdominal Aortic Aneurysm in Males: Insights Into the HMGB2–TREM Pathway

Reviews in Cardiovascular Medicine
Background: Abdominal aortic aneurysm (AAA) is a major public health challenge and presents high mortality due to diagnostic and therapeutic difficulties.
Liting Pan, Junji Chen, Yanjun Sun, Fang Wang   +3 more
doaj   +1 more source

Increased dermal expression of chromatin-associated protein HMGB1 and concomitant T-cell expression of the DNA RAGE in patients with psoriasis vulgaris

, 2019
Lisa Strohbuecker,1 Hans Koenen,2 Esther van Rijssen,2 Bram van Cranenbroek,2 Esther Fasse,2 Irma Joosten,2 Andreas Körber,1 Christoph Bergmann3 1Department of Dermatology, University Hospital Essen, 45147 Essen, Germany; 2Department of Laboratory ...
van Rijssen E, Joosten I, van Cranenbroek B, Fasse E, Körber A, Koenen H, Bergmann C, Strohbuecker L   +7 more
core  

Oxidization of HMGB1 and analysis.

, 2015
A, polyacrylamide SDS gel electrophoresis of reduced HMGB1 (lane 1), mildly oxidized HMGB1 (lane 2, intramolecular cross-links) and oxidized HMGB1 treated with 10 mM DTT (lane 3). HMGB1n indicates position of intermolecular cross-links of HMGB1.
Michal Štros (522792), Martin Kučírek (800136), Eva Polanská (522790), Šárka Pospíšilová (522791)   +3 more
core   +1 more source

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source