Results 131 to 140 of about 51,717 (306)

Relationship between HMGB1 and PAI-1 after allogeneic hematopoietic stem cell transplantation

, 2016
Shosaku Nomura,1 Yoshinobu Maeda,2 Kazuyoshi Ishii,1 Yuta Katayama,3 Hideo Yagi,4 Naoto Fujishima,5 Shuichi Ota,6 Masato Moriyama,7 Takayuki Ikezoe,8 Yasuhiko Miyazaki,9 Kunio Hayashi,10 Shinya Fujita,1 Atsushi Satake,1 Tomoki Ito,1 Taiichi Kyo,3 Mitsune
Ota S, Fujishima N, Maeda Y, Katayama Y, Ito T, Fujita S, Ishii K, Miyazaki Y, Kyo T, Satake A, Hayashi K, Yagi H, Ikezoe T, Moriyama M, Tanimoto M, Nomura S   +15 more
core  

Identification of NMDAR/HMGB1 interaction.

, 2013
HMGB1, in the absence (−) or the presence (+) of HMGB1(130–139), was added to solubilized membrane proteins from rat hippocampal synaptosomes. Immunoprecipitation procedure was performed using anti-HMGB1 (IP HMGB1) or anti-GluN1 (IP GluN1) antibodies ...
Sandro Pontremoli (309270), Monica Averna (164404), Manuela Marcoli (309265), Chiara Cervetto (309268), Daniela Frattaroli (309269), Guido Maura (309267), Franca Salamino (309263), Bianca Sparatore (309261), Marco Pedrazzi (309260), Edon Melloni (164418), Mauro Patrone (309262)   +10 more
core   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Myeloid cell-specific HMGB1 deficiency exaggerates mucoinflammatory responses but promotes bacterial clearance in mucoinflammatory lung disease

Scientific Reports
High mobility group box 1 (HMGB1), a highly conserved nuclear protein, is released into the extracellular milieu serving as a modulator of inflammatory responses. HMGB1 levels are elevated in the airspaces of CF patients and mice with cystic fibrosis (CF)
Yun Mao, Sonika Patial, Yogesh Saini
doaj   +1 more source

Non-Histone Chromatin Protein Dysregulation: The Oncogenic Role of HMGB1 and Its Redox States in ccRCC Inflammation and Genome Instability

Annals of Urologic Oncology
High Mobility Group Box 1 (HMGB1) is non-histone chromatin protein that plays important roles in maintaining nuclear architecture, transcriptional modulation, DNA replication, chromatin restructuring and DNA damage repair.
Betty Alex
doaj   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Serum level of HMGB1 protein and inflammatory markers in patients with secondary peritonitis: Time course and the association with clinical status [PDF]

Journal of Medical Biochemistry, 2017
Background: Intra-abdominal infection in secondary pe ritonitis drives as excessive production of inflammatory mediators and the development of systemic inflammatory response syndrome (SIRS) or sepsis.
Ilić Ljiljana M., Grigorov Ilijana, Krstić Slobodan, Ćeranić Miljan S., Jovanović Bojan, Stevanović Jelena, Peško Predrag   +6 more
doaj  

HMGB1 siRNA can reduce damage to retinal cells induced by high glucose in vitro and in vivo

, 2017
Shuang Jiang, Xiaolong Chen Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang, China Background: Diabetic retinopathy (DR), one of the most common complications of late-phase diabetes, is associated with many risk ...
Jiang S, Chen X
core  

GS‐9620 alleviates psoriasis‐like inflammation by regulating autophagy in keratinocytes

Animal Models and Experimental Medicine, EarlyView.
Psoriasis is an immune‐mediated inflammatory disease of the skin characterized by excessive proliferation and abnormal differentiation of keratinocytes. GS‐9620 can increase the expression of ATG5, ATG7 and ATG16L1, thereby regulating the autophagy of keratinocytes and inhibiting the secretion of related inflammatory factors.
Yansi Lyu, Wei Zhou, Pei Zhang, Chen Lin, Xin Wen, Zigang Zhao, Guoqiang Zhang, Qian Zhang, Si Chen   +8 more
wiley   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source