Results 131 to 140 of about 56,183 (304)

Relationship between HMGB1 and PAI-1 after allogeneic hematopoietic stem cell transplantation

, 2016
Shosaku Nomura,1 Yoshinobu Maeda,2 Kazuyoshi Ishii,1 Yuta Katayama,3 Hideo Yagi,4 Naoto Fujishima,5 Shuichi Ota,6 Masato Moriyama,7 Takayuki Ikezoe,8 Yasuhiko Miyazaki,9 Kunio Hayashi,10 Shinya Fujita,1 Atsushi Satake,1 Tomoki Ito,1 Taiichi Kyo,3 Mitsune
Ota S, Fujishima N, Maeda Y, Katayama Y, Ito T, Fujita S, Ishii K, Miyazaki Y, Kyo T, Satake A, Hayashi K, Yagi H, Ikezoe T, Moriyama M, Tanimoto M, Nomura S   +15 more
core  

A Direct Inhibitor of HMGB1 Cytokine

Chemistry & Biology, 2007
HMGB1 and the recently described interleukin-33 (IL-33) are abundant chromatin-associated nuclear factors with potent proinflammatory cytokine activities. In this issue of Chemistry & Biology, Mollica et al. [1] report the identification of the first direct small-molecule inhibitor of HMGB1.
openaire   +2 more sources

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source

The Ambiguous Role of HMGB1 Across the Hallmarks of Aging: A Narrative Review [PDF]

Manru Ning,1 Yihuai Liang,1,2 Liu Zhang,2 Feifei Wang,1,2 Li He3 1Yunnan Botanee Bio-Technology Group Co., Ltd, Kunming, Yunnan, 650106, People’s Republic of China; 2Yunnan Characteristic Plant Extraction Laboratory Co., Ltd., Kunming, Yunnan, 650106 ...
Ning M, Liang Y, Wang F, Zhang L, He L
core  

Oxidization of HMGB1 and analysis.

, 2015
A, polyacrylamide SDS gel electrophoresis of reduced HMGB1 (lane 1), mildly oxidized HMGB1 (lane 2, intramolecular cross-links) and oxidized HMGB1 treated with 10 mM DTT (lane 3). HMGB1n indicates position of intermolecular cross-links of HMGB1.
Michal Štros (522792), Martin Kučírek (800136), Eva Polanská (522790), Šárka Pospíšilová (522791)   +3 more
core   +1 more source

p65 enhanced METTL3-mediated m6A methylation of HMGB1 to promote microglia M1 polarization in sepsis-associated encephalopathy

Central European Journal of Immunology
Introduction Sepsis-associated encephalopathy (SAE) is a complication posing a significant risk to patient health and survival. Microglial polarization and inflammation are key to the pathological progression of SAE. The p65 subunit is a component of the 
Xiaowen Wu, Jie Wang, Jun Li, Guosheng Yao, Linyun Wei, Xuebin Li   +5 more
doaj   +1 more source

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

Advanced Science, EarlyView.
Magnetically guided macrophage immunobots integrate active tumor targeting with immunometabolic therapy. After systemic administration, magnetic actuation enhances immunobot retention and tumor penetration, while LPS‐functionalized FePt microrollers sustain M1‐like polarization through inflammatory and iron‐amplified oxidative signaling and trigger ...
Xirui Zeng, Yingfei Zhang, Chong Wu, Qijia Duan, Mengqi Fan, Kuan Wang, Shirong Cai, Immihan Ceren Yasa   +7 more
wiley   +1 more source

HMGB1 siRNA can reduce damage to retinal cells induced by high glucose in vitro and in vivo

, 2017
Shuang Jiang, Xiaolong Chen Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang, China Background: Diabetic retinopathy (DR), one of the most common complications of late-phase diabetes, is associated with many risk ...
Jiang S, Chen X
core  

Spatial Au+ Mapping Reveals a Self‐Amplifying Anti‐Tumor Immunity Loop Driven by Au(I) Complexes

Advanced Science, EarlyView.
The first report of spatial Au+ mapping of a representative gold complex (Au9). Macrophages, DCs, and tumor cells ranked as the top three in Au+ enrichment after Au9 treatment. Interestingly, Au9 treatment could induce ferroptosis and suppress cellular cholesterol, further eliciting a self‐amplifying anti‐tumor immunity loop.
Zhongren Xu, Zhiyue Fan, Lin Lv, Wei Lu, Zhenfan Wen, Wukun Liu   +5 more
wiley   +1 more source

Isocyanate‐Modified Melatplatin(IV) Enhances Antitumor Efficacy via TCF4/COL6A3‐Mediated Extracellular Matrix Remodeling and cGAS‐STING Pathway Activation in Bladder Cancer

Advanced Science, EarlyView.
A series of melatonin‐conjugated platinum(IV) prodrugs was functionalized with isocyanate chains (compounds 5‒12). MP‐12C (compound 11) was identified as the lead candidate, with optimal potency and safety. MP‐12C exhibited greater efficacy than cisplatin by increasing intracellular uptake, reshaping the extracellular matrix, activating the cGAS‐STING ...
Linhui Wang, Xiaomeng Liu, Tao Zhu, Zirun Su, Ruiping Liu, Zhe Li, Kaixuan Du, Kaipeng Jia, Chong Fu, Yuda Lin, Zihan Xue, Zhe Zhang, Chong Shen, Yunkai Qie, Zhouliang Wu, Zhiheng Liu, Kangkang Liu, Jingyuan Xu, Hailong Hu   +18 more
wiley   +1 more source