Results 111 to 120 of about 56,183 (304)

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Emerging roles for HMGB1 protein in immunity, inflammation, and cancer

, 2015
Simona Martinotti, Mauro Patrone, Elia Ranzato DiSIT – Dipartimento di Scienze e Innovazione Tecnologica, University of Piemonte Orientale, Alessandria, Italy Abstract: High-mobility group box 1 (HMGB1) protein is a member of the highly conserved ...
Martinotti S, Ranzato E, Patrone M
core  

Associations of HMGB1, sTNFR-1 and NLR with Premature Delivery Secondary to Infection in Pregnant Women Undergoing Cervical Cerclage

Clinical and Experimental Obstetrics & Gynecology
Background: Although cervical cerclage has improved with the rapid development of medical technology, there remains a distinct probability of adverse pregnancy outcomes.
Shengnan Cai, Yanting Wu, Yiqian Ding, Li Zeng   +3 more
doaj   +1 more source

Unlocking Long‐Lived Charge‐Separated State in Pentamethine Cyanine Based on Anionic Hofmeister Effect for Photodynamic Immunotherapy

Advanced Science, EarlyView.
Based on the anionic Hofmeister effect, a universal strategy of incorporation of stereo‐π anion BPh4− into a series of Cy5 skeletons to unlock long‐lived charge‐separated states was reported, wherein the weak electronic coupling and low charge recombination driving force hinder the charge recombination process, elevating the oxygen‐independent ROS ...
Xuan Zhao, Lei Jiang, Yingyong Ni, Ting Wang, Junjun Wang, Shengyu Shi, Jianhua Yu, Zhou Lu, Xiaojiao Zhu, Hongping Zhou   +9 more
wiley   +1 more source

Intracellular HMGB1 Negatively Regulates Efferocytosis

, 2011
High mobility group box 1 (HMGB1) is a highly conserved protein with multiple intracellular and extracellular functions, including transcriptional regulation, as well as modulation of inflammation, cell migration, and ingestion of apoptotic cells.
Jaroslaw W. Zmijewski, Edward Abraham, Arnaud Friggeri, Andressa de Freitas, Gang Liu, Sami Banerjee   +5 more
core   +1 more source

The Association Between Serum HMGB2 Levels and Abdominal Aortic Aneurysm in Males: Insights Into the HMGB2–TREM Pathway

Reviews in Cardiovascular Medicine
Background: Abdominal aortic aneurysm (AAA) is a major public health challenge and presents high mortality due to diagnostic and therapeutic difficulties.
Liting Pan, Junji Chen, Yanjun Sun, Fang Wang   +3 more
doaj   +1 more source

An Injectable Metal‐Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post‐Surgical Osteosarcoma Therapy

Advanced Science, EarlyView.
This work designed an injectable metal‐drug supramolecular condensate formed from hafnium ions and alendronate (Hf‐ALN) and loaded with the COX‐2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. Mechanistically, upon X‐ray irradiation, Hf enhances radiation energy deposition, ROS generation, and DNA damage ...
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang, Chengyun Ning, Guoxin Tan, Lei Zhou   +12 more
wiley   +1 more source

Non-Histone Chromatin Protein Dysregulation: The Oncogenic Role of HMGB1 and Its Redox States in ccRCC Inflammation and Genome Instability

Annals of Urologic Oncology
High Mobility Group Box 1 (HMGB1) is non-histone chromatin protein that plays important roles in maintaining nuclear architecture, transcriptional modulation, DNA replication, chromatin restructuring and DNA damage repair.
Betty Alex
doaj   +1 more source

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

Lactobacillus rhamnosus boosts immunity and survival in striped catfish (Pangasianodon hypophthalmus) via hmgb1 gene modulation against Aeromonas hydrophila infection

Journal of Basic and Applied Zoology
Background Probiotics are increasingly used in aquaculture to improve growth, enhance immune responses, and reduce antibiotic dependence. This study evaluated the effects of dietary Lactobacillus rhamnosus on growth performance, non-specific immunity ...
A. Testimona, R. Bharathi Rathinam, Arpit Acharya, S. G. Amulya, Gayatri Tripathi   +4 more
doaj   +1 more source