Results 101 to 110 of about 51,717 (306)
Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy
Advanced Science, EarlyView.ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang +10 more
wiley +1 more source
Self‐Accelerating Bimetallic Peroxide Nanozymes for Cascade‐Amplified Pyroptosis‐Immunotherapy
Advanced Science, EarlyView.Acidic tumor microenvironment‐responsive CuZnONPs enable triple‐combination therapy via self‐supplying H2O2, cascade nanozyme activities for ROS burst, and Zn2+‐activated pyroptosis, synergizing catalytic therapy with immunotherapy to convert cold tumors into hot ones.
Xuanyi Lu +9 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Colorectal cancer (CRC) remains therapeutically challenging due to high metastasis, recurrence, and immunotherapy resistance driven by tumor microenvironment‐mediated immune evasion. Immunogenic cell death (ICD) offers a promising strategy to reshape the immune microenvironment, yet existing ICD inducers suffer from poor targeting efficiency ...
Yao Xiao +12 more
wiley +1 more source
, 2014 Representative confocal merger images showing A: double immunofluorescent staining with anti-HMGB1 (red) and anti-NeuN (green), a marker for mature neurons.
Fulton T. Crews (445151) +1 more
core +1 more source
Role of HMGB1 on the onset of preeclampsia
BMC Pregnancy and ChildbirthThe molecular mechanisms differentiating early-onset preeclampsia (EO-PE) from late-onset preeclampsia (LO-PE) remain unclear. High Mobility Group Box 1 (HMGB1), a pro-inflammatory cytokine involved in immune responses and oxidative stress, has emerged as a potential contributor to PE pathogenesis.
Mehmet Yılmaz +7 more
openaire +5 more sources
A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance
Advanced Science, EarlyView.A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang +9 more
wiley +1 more source
HMGB1-valkuaisaineen merkitys verenkierron soluissa [PDF]
, 2008 The matrix of blood is a liquid plasma that transports molecules and blood cells within vessels lined by endothelial cells. High-mobility group B1 (HMGB1) is a protein expressed in blood cells.
Rouhiainen, Ari
core
Intracellular HMGB1 Negatively Regulates Efferocytosis
, 2011 High mobility group box 1 (HMGB1) is a highly conserved protein with multiple intracellular and extracellular functions, including transcriptional regulation, as well as modulation of inflammation, cell migration, and ingestion of apoptotic cells.
Jaroslaw W. Zmijewski +5 more
core +1 more source
, 2020 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject.
core +1 more source
HMGB1 in renal ischemic injury
American Journal of Physiology-Renal Physiology, 2012 Factors that initiate cellular damage and trigger the inflammatory response cascade and renal injury are not completely understood after renal ischemia-reperfusion injury (IRI). High-mobility group box-1 protein (HMGB1) is a damage-associated molecular pattern molecule that binds to chromatin, but upon signaling undergoes nuclear-cytoplasmic ...
May M, Rabadi +3 more
openaire +3 more sources