Results 241 to 250 of about 71,842 (286)

Proton beam therapy induces protective immunity via HMGB1-dependent signaling. [PDF]

Front Public Health
Wen J, Tu X, Ren W, Wang Q, Wang Y, Guo G, Osada K, Shimokawa T, Takahashi A, Nakajima NI, Zhang S, Gu W, Li Y, Li C, Sui L, Ma L.   +15 more
europepmc   +1 more source

Traditional Chinese Herbal Plant Penthorum chinense Pursh: Health Factors and Its Future Development

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This review expounds on the species, morphological characteristics, and distribution areas of Penthorum chinense Pursh, summarizes the active ingredients mainly including flavonoids in PCP and their extraction methods. It also pays particular attention to the pharmacological effects of PCP, such as liver protection, antioxidation, anti‐inflammation ...
Hui Zhang, Ning Zhang, Baoguo Sun
wiley   +1 more source

Promoting the nuclear retention of HMGB1 attenuates astrocyte senescence. [PDF]

J Neuroinflammation
Zhang N, Yang F, Shi J, Tang X, Fan A, Li W, Zhang F, Chai S, Chen Q, Wang C, Xu Y, Gong F, Lu Y, Zheng F.   +13 more
europepmc   +1 more source

Gut Commensal Klebsiella pneumoniae Extracellular Vesicles Shape a Liver Microenvironment Conducive to Gut‐Liver Bacterial Translocation and Pro‐Tumorigenic Processes

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Bacterial extracellular vesicles (EVs) are emerging mediators of host–microbe communication; however, their role in human disease remains unclear. Here, we identify two bacterial small tRNAs (tsRNAs) enriched in gut commensal Klebsiella pneumoniae‐derived EVs (KpEVs) that are markedly elevated in the serum of patients with hepatocellular ...
Shogo Tsubaki, Sho Nashimoto, Rika Tanaka, Touya Toyomoto, Hiroyasu Tsutsuki, Ken Kato, Jun Nakayama, Kiminori Kimura, Kazuki Oshima, Yusuke Yamamoto, Takuji Okusaka, Minoru Esaki, Nobuhiro Kawai, Nobuyuki Ota, Yusuke Yoshioka, Takahiro Ochiya, Yoshimasa Saito, Tomohiro Sawa, Katsuto Hozumi, Juntaro Matsuzaki, Hitoshi Tsugawa   +20 more
wiley   +1 more source

Tumor‐Bearing Status Accelerates Bleomycin‐Induced Pulmonary Inflammation via Endothelial Activation

Thoracic Cancer, Volume 17, Issue 7, April 2026.
In subcutaneous tumor‐bearing mice, inflammatory cell infiltration into the lung was aggravated via endothelial activation. The tumor‐bearing status additively aggravated BLM‐induced lung inflammation. Proinflammatory changes in the lungs accelerated by tumor‐bearing status might be involved in the development of drug‐induced lung inflammation ...
Shoko Isoyama, Kakuhiro Yamaguchi, Hiroshi Iwamoto, Yasushi Horimasu, Kunihiko Funaishi, Kiyofumi Shimoji, Shinjiro Sakamoto, Takeshi Masuda, Taku Nakashima, Shinichiro Ohshimo, Hironobu Hamada, Noboru Hattori   +11 more
wiley   +1 more source

M2 macrophage-secreted exosomal miR-216a regulates microglial polarization by targeting the HMGB1/TLR4/NF-κB pathway to alleviate bone cancer pain. [PDF]

Am J Transl Res
Cao S, Yang H, Li P, Li X, Shen S, Li Q, Huang Z.   +6 more
europepmc   +1 more source

Targeting inflammation in cardiometabolic disease: Icosapent ethyl modulates monocyte‐derived macrophages isolated from patients with cardiovascular disease with or without type 2 diabetes

Diabetic Medicine, Volume 43, Issue 4, April 2026.
Abstract Aims Despite intensive lipid‐lowering therapy, individuals with atherosclerotic cardiovascular disease (ASCVD) exhibit residual inflammatory risk, which drives recurrent cardiovascular events. This risk is amplified in type 2 diabetes mellitus (T2DM), where a pro‐inflammatory milieu accelerates atherogenesis. Monocyte‐derived macrophages (MDMs)
J. K. Ward, M. U. Shah, K. Lee, P. E. Squires, C. E. Hills   +4 more
wiley   +1 more source

Adipose Tissue-Derived Exosome and miR-142a-3p Alleviate Acute Lung Injury by Inhibiting HMGB1-Driven Autophagy. [PDF]

Cells
Long Q, Chen K, Li Y, Peng R, Yan Y, Ma J, Wang J, Song Q, Xue Y, Wang F.   +9 more
europepmc   +1 more source

Porphyromonas gingivalis–Derived Virulence Lipids Accelerate Osteoclastogenesis Independently of High Mobility Group Box Protein‐1 Canonical Signaling

Molecular Oral Microbiology, Volume 41, Issue 2, Page 85-93, April 2026.
ABSTRACT Periodontal bacterial pathogen‐associated molecular patterns (PAMPs) and damage‐associated molecular patterns (DAMPs) accelerate inflammatory osteoclastogenesis, resulting in alveolar bone loss. The core PAMP and DAMP prototype molecules are periodontal bacterium Porphyromonas gingivalis–derived virulence lipids, for example, phosphoglycerol ...
Chiaki Yamada, Gang Peng, James A. Johnson Jr., Amilia Nusbaum, Natasha Sanz, Hawra AlQallaf, Frank Nichols, Alexandru Movila   +7 more
wiley   +1 more source

High mobility group box 1 (HMGB1) is a potential disease biomarker in cell and mouse models of Duchenne muscular dystrophy

Biology Open
Rebecca A. Slick, Jessica Sutton, Margaret Haberman, Benjamin S. O'Brien, Jennifer A. Tinklenberg, Aashay Mardikar, Mariah J. Prom, Margaret Beatka, Melanie Gartz, Mark A. Vanden Avond, Emily Siebers, David L. Mack, J. Patrick Gonzalez, Allison D. Ebert, Kanneboyina Nagaraju, Michael W. Lawlor   +15 more
doaj   +1 more source