Results 181 to 190 of about 14,518 (216)
A Case of Anti-3-Hydroxy-Methylglutaryl-Coenzyme a Reductase (Anti-HMGCR) Immune-Mediated Necrotizing Myopathy. [PDF]
CureusGeorge JS +3 more
europepmc +1 more source
Beyond Hypothyroid Myopathy: Signal Recognition Particle (SRP)-Negative Necrotizing Dermatomyositis Unmasked by Anti-nuclear Matrix Protein 2 (Anti-NXP2) Positivity in a 60-Year-Old Woman With Hashimoto's Thyroiditis. [PDF]
CureusGoranti J +4 more
europepmc +1 more source
Pediatric Anti-HMGCR Myopathy–A Case Report
Journal of Orthopedics & Rheumatologyopenaire +1 more source
Cutaneous involvement in anti-HMGCR positive necrotizing myopathy
Journal of Autoimmunity, 2021 Anti-3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) positive immune-mediated necrotizing myopathy (IMNM) is a rare disease. It is induced by exogenous substances, most often by statins. Little is known about cutaneous manifestations of HMGCR positive IMNM and about HMGCR antibody positivity in other diseases.The characteristics of patients ...
Michael P Horn +2 more
exaly +4 more sources
Anti-HMGCR antibodies and asymptomatic hyperCKemia. A case report.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology, 2021 Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) related myositis is a form of immune-mediated necrotizing myopathy (IMNM). Anti-HMGCR autoantibodies target HMGCR, a glycoprotein linked to the endoplasmic reticulum implied in the cholesterol synthesis pathway, and exert a pathogenic effect on skeletal muscle cells. More than 60% of patients
Torri F. +4 more
openaire +3 more sources
Autoimmune necrotising myopathy and HMGCR antibodies
Practical Neurology, 2018 Statins lower serum cholesterol concentrations by inhibiting the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). Muscle side effects are relatively common and include asymptomatic elevation of serum creatine kinase (CK), myalgia, proximal muscle weakness and rhabdomyolysis. More recently, a subset of cases of immune-mediated necrotising
Kushan, Karunaratne +4 more
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Atypical presentation of anti-HMGCR myopathy
BMJ Case Reports, 2021Immune-mediated necrotising myopathy is a subtype of idiopathic inflammatory myopathy characterised by muscle fibre necrosis without significant inflammatory infiltrate. Anti-3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) myopathy is seen in 6%–10% of idiopathic inflammatory myopathy and is diagnosed in the context of elevated serum creatine ...
Rahul Karna +3 more
openaire +2 more sources
Statins and myositis: the role of anti-HMGCR antibodies
Expert Review of Clinical Immunology, 2015Muscle toxicity is a recognized adverse effect of statin use. Recently, a new myositis syndrome was described in association with antibodies directed against the pharmacologic target of statins, anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR antibody).
Albert, Selva-O'Callaghan +3 more
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Anti-HMGCR and anti-DFS70 antibodies immunofluorescence patterns
Autoimmunity Reviews, 2017We have replicated the findings of Alvarado-Cardenas et al. in our cohort of anti-HMGCR myositis patients, confirming the high specificity and sensibility of the rat liver IF pattern, especially when compared to the previously reported HEp-2 anti-HMGCR pattern.
Palterer, Boaz +3 more
openaire +2 more sources