Results 191 to 200 of about 14,518 (216)
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Revue Tunisienne de BIOLOGIE CLINIQUE, Vol. 31 No 2 (2024): Edition spéciale : «Auto-anticorps : le mystère révélé»
Soli, Arij, Bouzakoura, Firas
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Soli, Arij, Bouzakoura, Firas
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HMGCR positively regulated the growth and migration of glioblastoma cells
Gene, 2016The metabolic program of cancer cells is significant different from the normal cells, which makes it possible to develop novel strategies targeting cancer cells. Mevalonate pathway and its rate-limiting enzyme HMG-CoA reductase (HMGCR) have shown important roles in the progression of several cancer types.
Zhihua, Qiu +7 more
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Jessner Lymphocytic Infiltrate in Anti-HMGCR Myopathy
JAMA DermatologyThis case report describes a man in his 50s with type 2 diabetes and hyperlipidemia who was admitted for rash and proximal muscle weakness, pain, and unintentional 15-pound weight loss associated with anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) myopathy.
Joshua, Prenner +4 more
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Statin‐associated autoimmune myopathy and anti‐HMGCR autoantibodies
Muscle & Nerve, 2013ABSTRACTStatins are among the most commonly prescribed medications that significantly reduce cardiovascular risk in selected individuals. However, these drugs can also be associated with muscle symptoms ranging from mild myalgias to severe rhabdomyolysis. Although statin myotoxicity is usually self‐limited, in some instances statin‐exposed subjects can
Payam, Mohassel, Andrew L, Mammen
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CHARACTERISATION OF UK ANTI-HMGCR+ ANTIBODY ASSOCIATED MYOSITIS
Journal of Neurology, Neurosurgery & Psychiatry, 2016Introduction Anti-HMG-CoA Reductase (anti-HMGCR) antibodies are associated with an immune-mediated necrotising myopathy related to previous ‘statin’ use. The role of this antibody in pathogenesis is incompletely understood. We have thoroughly characterised a cohort of anti-HMGCR associated myositis patients to increase understanding of the role of ...
Murphy, Sean +8 more
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Effects of HMGCR deficiency on skeletal muscle development
Abstract Pathogenic variants in HMGCR were recently linked to a limb-girdle muscular dystrophy (LGMD) phenotype. The protein product HMG CoA reductase (HMGCR) catalyzes a key component of the cholesterol synthesis pathway.Mekala Gunasekaran +20 more
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VARIATION IN HMGCR AND NPC1L1 AND INFLAMMATORY BIOMARKERS
Journal of the American College of Cardiology, 2022Jiawen Li +7 more
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The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in Drosophila
Pharmaceuticals, 2022Sifang Liao +2 more
exaly
Necrosis in anti-SRP + and anti-HMGCR + myopathies
2018International ...
Allenbach, Yves +20 more
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