Structural basis for childhood antibody recognition of the human metapneumovirus fusion protein [PDF]
Nature CommunicationsHuman metapneumovirus (hMPV) is a significant cause of acute respiratory illness in children and older adults, with most children becoming seropositive by five years of age.
Ahmed Magdy Khalil +7 more
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Intranasal bovine/human parainfluenza virus 3 vaccine candidates expressing human metapneumovirus wild-type or pre-fusion F protein elicit protective immunity against human metapneumovirus in hamsters [PDF]
Journal of VirologyHuman metapneumovirus (HMPV) and human parainfluenza virus 3 (HPIV3) are among the leading causes of severe pediatric respiratory illness worldwide, and there are no licensed vaccines.
Sirle Saul +9 more
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Emergence and epidemiology of dominant variants of human metapneumovirus in the United States between 2016 and 2021 [PDF]
mBioHuman metapneumovirus (HMPV) causes acute respiratory disease worldwide and is the second leading cause of lower respiratory infection and hospitalization in young children in the USA. There is no licensed vaccine or therapeutic.
Lora Lee Pless +15 more
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Human metapneumovirus: pathogenesis, epidemiology, diagnostic technologies, and potential intervention strategies [PDF]
Virology JournalHuman metapneumovirus (HMPV) is a notable viral pathogen that is responsible for respiratory tract infections in infants, young children, elderly individuals, and immunocompromised individuals.
Guicai Gao, Ruihong Lin, Dongli Ma
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Frontiers in Microbiology, 2023 Human metapneumovirus (HMPV) is a common virus associated with acute respiratory distress syndrome in pediatric patients. There are no HMPV vaccines or therapeutics that have been approved for prevention or treatment.
Tian Chongyu +13 more
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HMPV in Immunocompromised Patients: Frequency and Severity in Pediatric Oncology Patients
Pathogens, 2020 Cancer is the first cause of death by disease in childhood globally. The most frequent types of cancers in children and adolescents are leukemias, followed by brain and central nervous system tumors and lymphomas.
Cesar Martinez-Rodriguez +1 more
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The human metapneumovirus matrix protein stimulates the inflammatory immune response in vitro. [PDF]
PLoS ONE, 2011 Each year, during winter months, human Metapneumovirus (hMPV) is associated with epidemics of bronchiolitis resulting in the hospitalization of many infants.
Audrey Bagnaud-Baule +8 more
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Human Metapneumovirus Is Capable of Entering Cells by Fusion with Endosomal Membranes. [PDF]
PLoS Pathogens, 2015 Human metapneumovirus (HMPV), a member of the Paramyxoviridae family, is a leading cause of lower respiratory illness. Although receptor binding is thought to initiate fusion at the plasma membrane for paramyxoviruses, the entry mechanism for HMPV is ...
Reagan G Cox +6 more
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International Journal of Infectious Diseases, 2023 Objectives: This study aimed to determine the epidemiological and genetic features of human metapneumovirus (HMPV) infection in children in southern China, and the effect of meteorological factors on infection.
Hengming Ye +13 more
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Human metapneumovirus (hMPV): a re-emerging respiratory threat – transmission, clinical features, complications and management [PDF]
Infectious Diseases and Tropical MedicineHuman metapneumovirus (hMPV) is a globally prevalent yet underrecognized respiratory pathogen that disproportionately affects high-risk populations. Between 2024 and January 2025, numerous hMPV clinical cases were recorded in China, India, and other ...
S. Aishath +3 more
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