Results 131 to 140 of about 137,694 (300)

Analysis of DevR regulated genes in Mycobacterium tuberculosis

open access: yes, 2014
The DevRS two component system of Mycobacterium tuberculosis is responsible for its dormancy in host and becomes operative under hypoxic condition. It is experimentally known that phosphorylated DevR controls the expression of several downstream genes in
Bandyopadhyay, Arnab   +3 more
core   +1 more source

Rethinking Perioperative Corticosteroids in Esophageal Cancer Surgery: Evidence From an Integrative Meta‐Analysis

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Esophagectomy remains a highly invasive procedure associated with substantial postoperative morbidity. Pulmonary complications, anastomotic leakage, and in‐hospital mortality are of particular concern. Perioperative corticosteroids are often administered to attenuate excessive inflammatory responses; however, the clinical impact in ...
Tomohiko Yasuda   +4 more
wiley   +1 more source

Molecular characterisation of Newcastle disease virus exotic isolate in East Java, Indonesia

open access: yesBulgarian Journal of Veterinary Medicine, 2021
Newcastle disease virus (NDV) is ssRNA paramyxovirus causing clinical signs, varying from subclinical infections to 100% mortality in infected chickens. Haemagglutinin-neuraminidase (HN) protein has an important role related to infection and pathogenesis,
N. Kusumarahayu   +5 more
doaj   +1 more source

Stochastic phenotype transition of a single cell in an intermediate region of gene-state switching

open access: yes, 2015
Multiple phenotypic states often arise in a single cell with different gene-expression states that undergo transcription regulation with positive feedback. Recent experiments have shown that at least in E.
Ge, Hao   +2 more
core   +1 more source

SUN/KASH interactions facilitate force transmission across the nuclear envelope. [PDF]

open access: yes, 2019
LINC complexes (Linker of Nucleoskeleton and Cytoskeleton), consisting of inner nuclear membrane SUN (Sad1, UNC-84) proteins and outer nuclear membrane KASH (Klarsicht, ANC-1, and Syne Homology) proteins, are essential for nuclear positioning, cell ...
Hao, Hongyan, Starr, Daniel A
core  

Biallelic Germline Inactivation of HROB Causes Primary Gonadal Insufficiency and is Potentially Associated with Colonic Polyposis Predisposition

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The Homologous Recombination Factor With OB‐Fold (HROB) plays a role in homologous recombination and DNA replication, where it enhances the MCM8‐MCM9 helicase complex activity. Recent findings link biallelic germline HROB variants to primary gonadal insufficiency (hypergonadotropic hypogonadism), a phenotype also associated with MCM8/MCM9 ...
Noah C. Helderman   +15 more
wiley   +1 more source

Reaction-diffusion kinetics on lattice at the microscopic scale

open access: yes, 2018
Lattice-based stochastic simulators are commonly used to study biological reaction-diffusion processes. Some of these schemes that are based on the reaction-diffusion master equation (RDME), can simulate for extended spatial and temporal scales but ...
Arjunan, Satya N. V.   +5 more
core   +1 more source

Domain architecture and oligomerization properties of the paramyxovirus PIV 5 hemagglutinin-neuraminidase (HN) protein

open access: yesVirology, 2008
The mechanism by which the paramyxovirus hemagglutinin-neuraminidase (HN) protein couples receptor binding to activation of virus entry remains to be fully understood, but the HN stalk is thought to play an important role in the process. We have characterized ectodomain constructs of the parainfluenza virus 5 HN to understand better the underlying ...
Yuan, Ping   +4 more
openaire   +2 more sources

Mechanisms of Mitochondrial Toxicity and Cytotoxicity Caused by Pseudomonas aeruginosa Pyocyanin in Human Nasal Epithelial Cells

open access: yesInternational Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Pseudomonas aeruginosa is an opportunistic pathogen in cystic fibrosis‐related chronic rhinosinusitis (CF‐CRS) that produces phenazine metabolites pyocyanin and 1‐hydroxyphenazine (1‐HP), which may have detrimental effects on mitochondria, reactive oxygen species (ROS), Ca2+ signaling, and apoptosis.
Joel C. Thompson   +8 more
wiley   +1 more source

In Vivo Production of HN Protein Increases the Protection Rates of a Minicircle DNA Vaccine against Genotype VII Newcastle Disease Virus. [PDF]

open access: yesVaccines (Basel), 2021
Wang Z   +15 more
europepmc   +1 more source

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