Results 221 to 230 of about 137,694 (300)

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

IgG Fc binding protein (FCGBP) inhibits the development of laryngeal squamous cell carcinoma and cisplatin resistance through the PIGR/JAK2/STAT3 pathway. [PDF]

Radiol Oncol
Wan X, Zeng Y, Xiong M, Chen L, Bai Y.
europepmc   +1 more source

Expression of Glycoprotein B (gB) Correlates With Poor Prognosis in Nasopharyngeal Carcinoma

Cancer Science, EarlyView.
The extent of EBV lytic replication in NPC has not been fully clarified. Our study demonstrated EBV replication and release in NPC and identified a significant association between expression of the late lytic protein gB and poor prognosis. These findings suggest that late lytic gene products may contribute to tumor progression and that gB represents a ...
Shigetaka Komura, Satoru Kondo, Hideya Kawasaki, Shinji Watanabe, Satoshi Yamada, Hirotomo Dochi, Han Gia Nguyen, Isao Ohta, Makiko Moriyama‐Kita, Masaki Fukuyo, Kousho Wakae, Yuki Kitagawa, Harue Mizokami, Luyao Liu, Nobuyuki Hirai, Eiji Kobayashi, Takayoshi Ueno, Yosuke Nakanishi, Kazuhira Endo, Hisashi Sugimoto, Naohiro Wakisaka, Rikinari Hanayama, Kiyoshi Misawa, Atsushi Kaneda, Tomokazu Yoshizaki   +24 more
wiley   +1 more source

Chromosome-level genome assembly of triploid Cyperus rotundus uncovers allelic expression patterns and herbicide resistance mechanisms. [PDF]

Plant Commun
Wu L, Luo Z, Lu Y, Li J, Liu M, Cai H, Zhao S, Huang J, Yi L, He S, Bai L, Pan L.   +11 more
europepmc   +1 more source

Cholangiolocellular Component Predicts a Biologically Distinct Subgroup of Mass‐Forming Intrahepatic Cholangiocarcinoma

Cancer Science, EarlyView.
We identified two distinct molecular subgroups of mass‐forming intrahepatic cholangiocarcinoma (MF‐iCCA) based on the presence of a histological cholangiolocellular carcinoma (CLC) component. The CLC‐related molecular subgroup showed better prognosis and highly angiogenic features, as confirmed by both genetic analysis and morphological observation ...
Naoto Kubota, Ken Yamazaki, Yasuhito Arai, Minoru Esaki, Nobuyoshi Hiraoka, Hirofumi Shirakawa, Moriaki Tomikawa, Tatsuhiro Shibata, Michiie Sakamoto, Hidenori Ojima   +9 more
wiley   +1 more source

Insights into the multifunctionality of viral glycoproteins F and HN in the lifecycle and pathogenesis of Newcastle disease virus: a systematic review. [PDF]

Vet Res
Ma S, Xia R, Wu W, Duan Z.
europepmc   +1 more source

TGF‐β Inhibitor Potentiates Osimertinib‐Induced Anti‐Tumor Immunity in Egfr‐Mutant Lung Cancer

Cancer Science, EarlyView.
Osimertinib enhances CD8+ T cell activity but also upregulates immunosuppressive TGF‐β in Egfr‐mutant lung tumors. This study demonstrates that TGF‐β inhibition with nintedanib or vactosertib potentiates osimertinib‐induced CD8+ T cell–mediated immunity and reduce CD206+ macrophages. These findings provide a strong rationale for novel immunotherapeutic
Tadahiro Kuribayashi, Jun Nishimura, Sachi Okawa, Masataka Taoka, Shunta Mori, Takaaki Tanaka, Tomoka Nishimura, Ayako Morita, Naofumi Hara, Kiichiro Ninomiya, Go Makimoto, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Yosuke Togashi, Yoshinobu Maeda, Katsuyuki Kiura, Kadoaki Ohashi   +17 more
wiley   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems. [PDF]

Adv Healthc Mater
Qu J, Wu R, Jiang H, Chen L, Tian Y, Zeng S, Liu T, Zhao C, Shi H, Liang X, Zhao Y.   +10 more
europepmc   +1 more source

Serological responses of Sport horses pre‐ and post‐third vaccination with Strangvac

Equine Veterinary Education, EarlyView.
Summary Background Strangles, caused by Streptococcus equi, is an endemic disease of horses throughout the world. A vaccine against strangles, Strangvac, is available in Europe, but there are no published serological data following the revaccination of Sport horses.
U. Hedenström, F. Righetti, I. Zahl, B. Henriques‐Normark, A. Gustafsson, E. Hartman, R. Paillot, A. Ruiz, A. S. Waller   +8 more
wiley   +1 more source

Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease. [PDF]

Int J Mol Sci
Rodríguez-Esparragón F, Cazorla-Rivero SE, Torrealba E, Cánovas-Molina Á, González-Hernández AN, Martín-Alfaro R, Afonso-Medina MP, Martínez de Saavedra-Álvarez MT, Pérez-Santana CG, Bartolomé C, Estupiñán L, González-Martín JM, Clavo B.   +12 more
europepmc   +1 more source