Results 91 to 100 of about 9,918 (148)

BVES-AS1-201-50aa interacts with the Src/mTOR pathway in CRC cells.

, 2023
(A) Vector- or ORF-wt-transfected HCT116 cells were lysed and incubated with beads-coupled anti-Flag antibody or isotype IgG. The precipitated proteins were isolated from the beads and subjected to SDS-PAGE electrophoresis before silver staining. (B) The
Weiwei Zheng (140828), Yucheng Song (14231285), Yingchang Guo (16425979), Guangtan Zhang (16425982), Xuebin Bao (16425988), Junwei Bai (9730322), Xiaofei Song (3111648), Qinhui Zhu (16425985), Chao Zhang (51048), Gang Wu (23885)   +9 more
core   +1 more source

Epitranscriptomic RNA m6A Modification in Cancer Therapy Resistance: Challenges and Unrealized Opportunities

Advanced Science, Volume 12, Issue 4, January 27, 2025.
Tumors develop resistance to therapeutic agents, unfortunately, efforts to overcome resistance have achieved limited success. m6A RNA modification dysregulation is an emerging mechanism for cancer therapy resistance. This review comprehensively discusses recent studies regarding the contributions of m6A modification and its regulators to cancer therapy
Mohammad Burhan Uddin, Zhishan Wang, Chengfeng Yang   +2 more
wiley   +1 more source

Recent advances in noncoding RNA modifications of gastrointestinal cancer

Cancer Science, Volume 116, Issue 1, Page 8-20, January 2025.
Functional overview of RNA modifications. Some modifications of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) activate and others inactivate signals that promote cancer progression. Abstract Elucidating the mechanisms underlying cancer development and proliferation is important for the development of therapeutic ...
Tomoaki Hara, Sikun Meng, Yasuko Arao, Yoshiko Saito, Kana Inoue, Sarah Rennie, Ken Ofusa, Yuichiro Doki, Hidetoshi Eguchi, Toru Kitagawa, Hideshi Ishii   +10 more
wiley   +1 more source

Does Adding Single‐Nucleotide Polymorphisms to Risk Algorithms Improve Cardiovascular Disease Risk Prediction in Rheumatoid Arthritis? An Internal and External Validation of a Clinical Risk Score

Arthritis Care &Research, Volume 76, Issue 10, Page 1419-1426, October 2024.
Objective Current risk algorithms do not accurately predict cardiovascular disease (CVD) risk in rheumatoid arthritis (RA). An area of interest is that of single‐nucleotide polymorphisms (SNPs), of which several have been associated with CVD in the general population.
Rabia Agca, Calin D. Popa, Martijn W. Heymans, Bart Crusius, Alexandre E. Voskuyl, Michael T. Nurmohamed   +5 more
wiley   +1 more source

Protein posttranslational modifications in metabolic diseases: basic concepts and targeted therapies

MedComm, Volume 5, Issue 10, October 2024.
Posttranslational modifications of proteins are involved in the development of metabolism‐related diseases such as diabetes mellitus, obesity, hyperlipidemia, and nonalcoholic fatty liver disease. PTMs mediates the development of diabetes mellitus by affecting insulin homeostasis, glucose metabolism, diabetic complications, gluconeogenesis, and β‐cell ...
Yunuo Yang, Jiaxuan Wu, Wenjun Zhou, Guang Ji, Yanqi Dang   +4 more
wiley   +1 more source

HNF1A-MODY Mutations in Nuclear Localization Signal Impair HNF1A-Import Receptor KPNA6 Interactions

, 2021
#nofulltext# --- Fareed, Fareed M. A. (Arel Author), Çapan Yalçın, Özlem (Arel Author)Mutations in hepatocyte nuclear factor (HNF)1A gene cause the most common form of Maturity-onset diabetes of the young (MODY), a monogenic subtype of diabetes mellitus.
Fareed, Fareed M. A., Korulu, Şirin, Capan, Ozlem Yalcin, Özbil, Mehmet, Çapan Yalçın, Özlem   +4 more
core   +1 more source

PIN1P1 is activated by CREB1 and promotes gastric cancer progression via interacting with YBX1 and upregulating PIN1

Journal of Cellular and Molecular Medicine, Volume 28, Issue 1, January 2024.
Abstract Long noncoding RNAs (lncRNAs) play critical roles in the carcinogenesis and progression of cancers. However, the role and mechanism of the pseudogene lncRNA PIN1P1 in gastric carcinoma remain unclear. The expression and effects of lncRNA PIN1P1 in gastric cancer were investigated.
Ya‐Wen Wang, Wen‐Jie Zhu, Ran‐Ran Ma, Ya‐Ru Tian, Xu Chen, Peng Gao   +5 more
wiley   +1 more source

Regulatory mechanisms and potential medical applications of HNF1A-AS1 in cancers.

American journal of translational research
Long noncoding RNAs (lncRNAs) are defined as a class of non-protein-coding RNAs that are longer than 200 nucleotides. Previous studies have shown that lncRNAs play a vital role in the progression of multiple diseases, which highlights their potential for medical applications.
Yang, Zhang, Jiang, Shi, Junfang, Luo, Cong, Liu, Lixu, Zhu   +4 more
openaire   +1 more source

N6-Methyladenosine-Modified ATP8B1-AS1 Exerts Oncogenic Roles in Hepatocellular Carcinoma via Epigenetically Activating MYC

, 2023
Chuan Tan,1,* Yanyan Huang,2,* Zheng Huang,2,* Yuanjia Ning,2 Lizheng Huang,2 Xianjian Wu,1 Yuan Lu,1 Huamei Wei,3 Jian Pu1 1Department of Hepatobiliary Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise ...
Huang Y, Huang Z, Lu Y, Ning Y, Tan C, Pu J, Wei H, Huang L, Wu X   +8 more
core  

Lipoprotein composition in HNF1A-MODY: Differentiating between HNF1A-MODY and Type 2 diabetes.

, 2012
INTRODUCTION:The young-onset diabetes seen in HNF1A-MODY is often misdiagnosed as Type 2 diabetes. Type 2 diabetes, unlike HNF1A-MODY, is associated with insulin resistance and a characteristic dyslipidaemia.
Young, Ian, Malecki, MT, Hattersley, AT, McEneny, J., Thanabalasingham, Gaya, Owen, Katharine R., Pearson, Ewan R.; id_orcid, Young, IS, McEneny, Jane, Shields, B.M., Young, I. S., Pearson, E.R., Owen, K. R., Shields, Beverley, Malecki, M. T., Szopa, Magdalena, Thanabalasingham, G., Young, Ian S., McDonald, T.J., McDonald, TJ, Shields, BM, Ellard, S., Hattersley, A.T., Hattersley, Andrew T., Owen, Katharine, Malecki, Maciej T., Shields, Beverley M., McEneny, J, Malecki, M.T., Thanabalasingham, G, Pearson, E. R., Owen, KR, Szopa, M., Pearson, ER, Szopa, M, Owen, K.R., Ellard, S, McDonald, Tim J., Ellard, Sian, McDonald, Timothy J.   +39 more
core   +1 more source