Results 81 to 90 of about 9,918 (148)
Proposed model of PYCARD-AS1-mediated PYCARD regulation.
, 2019 PYCARD transcription is activated in the case of PYCARD-AS1 silencing (A). Upon transcribed from the opposite strand of the PYCARD gene, a fraction of PYCARD-AS1 transcripts localize at PYCARD promoter via the 5′ region, and interact with DNMT1 and G9a ...
Chunfang Gao (468281) +10 more
core +1 more source
, 2022 Melanoma is the most lethal skin cancer that originates from epidermal melanocytes. Recently, long non-coding RNAs (lncRNAs) are emerging as critical regulators of cancer pathogenesis and potential therapeutic targets.
Tao Zhao (341704) +13 more
core +1 more source
The m6A Reader YTHDF3 Promotes Glioma Progression by Regulating the m6A Modification of lncRNA‐PAR5
Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.Background Long non‐coding RNA PAR5 (lncRNA‐PAR5) is downregulated in glioma and has been confirmed to inhibit glioma progression; however, the specific regulatory mechanism underlying its downregulation remains unclear. Objective This study aimed to investigate the key molecular mechanism by which PAR5 inhibits glioma progression, with a focus on the ...
LiuFei Xu +6 more
wiley +1 more source
, 2022 Melanoma is the most lethal skin cancer that originates from epidermal melanocytes. Recently, long non-coding RNAs (lncRNAs) are emerging as critical regulators of cancer pathogenesis and potential therapeutic targets.
Tao Zhao (341704) +13 more
core +1 more source
Liver‐specific lncRNAs associated with liver cancers
FEBS Open Bio, Volume 15, Issue 9, Page 1383-1405, September 2025.Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina +3 more
wiley +1 more source
The complex regulatory network of the 336 unique proteins interacted with BVES-AS1-201-50aa.
, 2023 The complex regulatory network of the 336 unique proteins interacted with BVES-AS1-201-50aa.
Weiwei Zheng (140828) +9 more
core +1 more source
Journal of Cell Communication and Signaling, Volume 19, Issue 3, September 2025.The interaction between inflammasomes and autophagy is crucial for maintaining the balance between necessary immune responses and the avoidance of excessive inflammation. Autophagy can inhibit the activation of the NLRP3 inflammasome by degrading endogenous activators, such as damaged mitochondria that produce reactive oxygen species (ROS), as well as ...
Sai Liu, Jingzhou Zhang
wiley +1 more source
The Common HNF1A Variant I27L is a Modifier of Age at Diabetes Diagnosis in HNF1A-MODY Individuals. [PDF]
, 2018 There is wide variation in the age at diagnosis of diabetes in individuals with Maturity-Onset Diabetes of the Young (MODY) due to a mutation in the HNF1A gene.
JM Locke (21825998) +10 more
core +5 more sources
PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment
MedComm, Volume 6, Issue 8, August 2025.The PI3K/AKT/mTOR signaling axis is crucial in cancer progression, regulating cell growth, survival, and metabolism. Often hyperactivated through mutations or loss of tumor suppressors such as PTEN, this pathway promotes cancer cell proliferation and survival by inhibiting apoptosis and activating mTOR, which drives protein synthesis and suppresses ...
Mingyang Jiang +10 more
wiley +1 more source
Cancer Science, Volume 116, Issue 5, Page 1324-1338, May 2025.This study highlights the role of Differentiation Antagonizing Non‐Protein Coding RNA (DANCR) as an oncogene in esophageal squamous cell carcinoma (ESCC), showing its high expression and involvement in tumor progression both in vitro and in vivo. By sponging miR‐3193 and regulating the target gene DDIT3, DANCR plays a critical role in ESCC development,
Heng Xiao +5 more
wiley +1 more source