Results 61 to 70 of about 11,404 (127)

Cystatin C is not a good candidate biomarker for HNF1A-MODY. [PDF]

, 2013
Cystatin C is a marker of glomerular filtration rate (GFR). Its level is influenced, among the others, by CRP whose concentration is decreased in HNF1A-MODY. We hypothesized that cystatin C level might be altered in HNF1A-MODY.
James, T. J., Kiec-Wilk, B., Mlynarski, W., Thanabalasingham, Gaya, Nowak, Natalia, Owen, Katharine R., Owen, K. R., Skupień, Jan, Kozek, Elżbieta, Malecki, M. T., Szopa, Magdalena, Thanabalasingham, G., Kieć-Wilk, Beata, Kozek, E., Hattersley, Andrew T., Colclough, Kevin, James, Timothy J., Młynarski, Wojciech Michał, Szopa, M., Nowak, N., Małecki, Maciej, Skupien, J., McDonald, Tim J., McDonald, Timothy J.   +23 more
core   +1 more source

Recent advances in noncoding RNA modifications of gastrointestinal cancer

Cancer Science, Volume 116, Issue 1, Page 8-20, January 2025.
Functional overview of RNA modifications. Some modifications of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) activate and others inactivate signals that promote cancer progression. Abstract Elucidating the mechanisms underlying cancer development and proliferation is important for the development of therapeutic ...
Tomoaki Hara, Sikun Meng, Yasuko Arao, Yoshiko Saito, Kana Inoue, Sarah Rennie, Ken Ofusa, Yuichiro Doki, Hidetoshi Eguchi, Toru Kitagawa, Hideshi Ishii   +10 more
wiley   +1 more source

Does Adding Single‐Nucleotide Polymorphisms to Risk Algorithms Improve Cardiovascular Disease Risk Prediction in Rheumatoid Arthritis? An Internal and External Validation of a Clinical Risk Score

Arthritis Care &Research, Volume 76, Issue 10, Page 1419-1426, October 2024.
Objective Current risk algorithms do not accurately predict cardiovascular disease (CVD) risk in rheumatoid arthritis (RA). An area of interest is that of single‐nucleotide polymorphisms (SNPs), of which several have been associated with CVD in the general population.
Rabia Agca, Calin D. Popa, Martijn W. Heymans, Bart Crusius, Alexandre E. Voskuyl, Michael T. Nurmohamed   +5 more
wiley   +1 more source

Lipoprotein composition in HNF1A-MODY: Differentiating between HNF1A-MODY and Type 2 diabetes.

, 2012
INTRODUCTION:The young-onset diabetes seen in HNF1A-MODY is often misdiagnosed as Type 2 diabetes. Type 2 diabetes, unlike HNF1A-MODY, is associated with insulin resistance and a characteristic dyslipidaemia.
Young, Ian, McEneny, J., Thanabalasingham, Gaya, Owen, Katharine R., Pearson, Ewan R.; id_orcid, McEneny, Jane, Shields, B.M., Young, I. S., Pearson, E.R., Owen, K. R., Shields, Beverley, Malecki, M. T., Szopa, Magdalena, Thanabalasingham, G., Young, Ian S., McDonald, T.J., Ellard, S., Hattersley, A.T., Hattersley, Andrew T., Malecki, Maciej T., Shields, Beverley M., Malecki, M.T., Pearson, E. R., Szopa, M., Owen, K.R., McDonald, Tim J., Ellard, Sian, McDonald, Timothy J.   +27 more
core   +1 more source

Protein posttranslational modifications in metabolic diseases: basic concepts and targeted therapies

MedComm, Volume 5, Issue 10, October 2024.
Posttranslational modifications of proteins are involved in the development of metabolism‐related diseases such as diabetes mellitus, obesity, hyperlipidemia, and nonalcoholic fatty liver disease. PTMs mediates the development of diabetes mellitus by affecting insulin homeostasis, glucose metabolism, diabetic complications, gluconeogenesis, and β‐cell ...
Yunuo Yang, Jiaxuan Wu, Wenjun Zhou, Guang Ji, Yanqi Dang   +4 more
wiley   +1 more source

PIN1P1 is activated by CREB1 and promotes gastric cancer progression via interacting with YBX1 and upregulating PIN1

Journal of Cellular and Molecular Medicine, Volume 28, Issue 1, January 2024.
Abstract Long noncoding RNAs (lncRNAs) play critical roles in the carcinogenesis and progression of cancers. However, the role and mechanism of the pseudogene lncRNA PIN1P1 in gastric carcinoma remain unclear. The expression and effects of lncRNA PIN1P1 in gastric cancer were investigated.
Ya‐Wen Wang, Wen‐Jie Zhu, Ran‐Ran Ma, Ya‐Ru Tian, Xu Chen, Peng Gao   +5 more
wiley   +1 more source

The expression profile of the HNF1A gene in human, mouse and rat.

, 2013
The expression profile of the HNF1A gene in human, mouse and rat is given. The species is given on the X-axis and the relative quantification of each isoform relative to the B2M gene is given on the Y-axis.
Lorna W. Harries (336166), Anna L. Gloyn (146286), James E. Brown (369339)   +2 more
core   +1 more source

DataSheet_2_Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway.zip

, 2022
Melanoma is the most lethal skin cancer that originates from epidermal melanocytes. Recently, long non-coding RNAs (lncRNAs) are emerging as critical regulators of cancer pathogenesis and potential therapeutic targets.
Tao Zhao (341704), Jingjing Ma (419752), Tianwen Gao (262800), Peng Xu (17962), Qiong Shi (244677), Xiuli Yi (166944), Yuqi Yang (1608304), Weinan Guo (4727631), Sen Guo (1846828), Lin Liu (74495), Chunying Li (166955), Weigang Zhang (1333242), Yu Liu (6938), Qiao Yue (11939732)   +13 more
core   +1 more source

The Common HNF1A Variant I27L is a Modifier of Age at Diabetes Diagnosis in HNF1A-MODY Individuals.

, 2018
There is wide variation in the age at diagnosis of diabetes in individuals with Maturity-Onset Diabetes of the Young (MODY) due to a mutation in the HNF1A gene.
JM Locke (21825998), C Saint-Martin (21320024), LW Harries (21821876), S Ellard (13734760), SA Sharp (21883175), AT Hattersley (7655273), TW Laver (21853583), C Bellanné-Chantelot (21883178), KA Patel (21320144), AR Wood (7715282), MN Weedon (7655270)   +10 more
core   +4 more sources

Additional file 7 of LncRNA FAM83H-AS1 promotes the malignant progression of pancreatic ductal adenocarcinoma by stabilizing FAM83H mRNA to protect β-catenin from degradation

, 2022
Additional file 7: Supplementary Figure 1. Hierarchical cluster heat map of differentially expressed lncRNAs in PDAC and corresponding normal tissues generated from RNA sequencing data from the TCGA database.
Taoyuan Yin (13877676), Tingting Qin (394064), Chunle Zhao (5890493), Min Zhou (173135), Renyi Qin (2831852), Yuhui Liu (669854), Xingjun Guo (2831858), Jun Gong (475433), Yongkang Shi (13877682), Zhenxiong Zhang (13877679), Yu Bai (258833), Shutao Pan (7143704), Min Wang (21070), Yang Gao (18005)   +13 more
core   +1 more source