Results 41 to 50 of about 11,404 (127)

Additional file 1: of The HNF1α-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1

, 2018
Figure S1. Identification of HNF1α-regulated lncRNAs. Figure S2. HNF1α directly binds to the promoter region of HNF1A-AS1. Figure S3. HNF1A-AS1 suppresses the malignancy of HCC cells. Figure S4. Enforced expression of HNF1A-AS1 suppresses tumourigenicity
Kai-xian Chen (4874275), Shi-Jie Chen (17002), Cheng Luo (48047), Jian Wang (5901), Liang-Zhi Wen (4874272), Chen-Hong Ding (4874269), Xin Zhang (35492), Shu-Juan Lei (4874281), Jin-Pei Liu (4874266), Wei-Fen Xie (4874278), Chuan Yin (2866601), Hua-liang Jiang (266033), Kai Ding (783198)   +12 more
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Regulation of HNF1A in human pancreatic β-cells

, 2022
HNF1A is a transcription factor important for normal pancreatic β-cell function. Heterozygous mutations in HNF1A result in monogenic diabetes. Furthermore, rare and common variants in HNF1A influence Type 2 diabetes risk.
Font Cunill, Berta
core   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Gastric Cancer: Pathobiology and Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
Gastric cancer is a multistep process driven by the interplay of microbial virulence, host epithelial injury, and evolving molecular reprogramming. Initiation involves pathogen‐induced epigenetic alterations and the early subversion of key oncogenic signaling networks, facilitating the transition from chronic injury to metaplasia and malignant ...
Ruixian Yu, Miao Zhang, Yan Meng, Chunxiao Zhu, Weihong Zhang, Hui Zhang, Zhifa Cao, Meihang Du, Zhangting Zhao, Junping Bai, Yi Han, Yang Tang, Wei Kang, Ka Fai To, Shi Jiao, Liwei An, Zhaocai Zhou   +16 more
wiley   +1 more source

Targeting EZH2 in Cancer: From Molecular Mechanisms to Clinical Translation

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The abnormal overexpression or gain‐of‐function mutations of EZH2 play a significant role in cancer occurrence and progression, highlighting the importance and potential of EZH2 as a cancer biomarker. Therefore, screening for effective and safe small‐molecule inhibitors, degraders, and natural compounds targeting EZH2 through preclinical cancer models ...
Xi Zhong, Jieni Li, Mingxuan Pan, Xiaoxue Ke, Hongjuan Cui   +4 more
wiley   +1 more source

Mutations in HNF1A Result in Marked Alterations of Plasma Glycan Profile [PDF]

, 2013
A recent genome-wide association study identified hepatocyte nuclear factor 1-α (HNF1A) as a key regulator of fucosylation. We hypothesized that loss-of-function HNF1A mutations causal for maturity-onset diabetes of the young (MODY) would display altered
Klimes, Iwar, Rudd, Pauline M., Muzinic, Ana, Reynolds, Rebecca M., McCarthy, Mark I, Redzic, I., Mughal, Saima A, Redzic, Irma, Stanik, Juraj, Kattla, Jayesh J., Zgaga, Lina, Rudan, Igor, Kokic, I., Primorac, Dragan, Owen, Katharine R, Tjora, Erling, Strachan, M. W. J., Huffman, Jennifer E., Pucic, Maja, Wilson, J. F., Gasperikova, Daniela, Hassanali, N., Adamczyk, Barbara, Wilson, James F, Hayward, C., Mughal, S. A., Hayward, Caroline, Adamczyk, B., Pedersen, Oluf B, Klimes, I., Campbell, Harry, Muzinic, A., Rudd, Pauline M, Gyllensten, Ulf, Hastie, Nicholas D, Wright, A. F., Wild, S. H., Nielsen, Trine, Thanabalasingham, G., Strachan, Mark W J, Bennett, Amanda J, Lauc, Gordan, Reynolds, R. M., Pucic, M., Bennett, Amanda J., Gloyn, A. L., Mughal, Saima A., Novokmet, Mislav, Strachan, Mark W. J., Zgaga, L., Wright, Alan F., Wright, Alan F, Polasek, Ozren, Polasek, O., Njolstad, P. R., Owen, K. R., McCarthy, M. I., Njolstad, Pal R., Njølstad, Pål R, Wild, Sarah H; id_orcid, Kattla, Jayesh J, Huffman, J. E., Gyllensten, Ulf,, Campbell, Harry; id_orcid, Nielsen, T., Stanik, J., Rudd, P. M., Wild, Sarah H, Gasperikova, D., Kolcic, Ivana, Novokmet, M., Rudan, I., Hansen, Torben, Reynolds, Rebecca M, Essafi, A., Primorac, D., Wilson, James F., Kattla, J. J., Thanabalasingham, Gaya, Hastie, N. D., Wild, Sarah H., Gyllensten, U., Gloyn, Anna L, Campbell, H., Gloyn, Anna L., Owen, Katharine R., Bennett, A. J., Hassanali, Neelam, Lauc, G., Wilson, James F; id_orcid, Essafi, Abdelkader, Huffman, Jennifer E, Kokic, Ivana, Hayward, Caroline; id_orcid, Pedersen, Oluf B., Hastie, Nicholas D., McCarthy, Mark I., Gornik, Olga, Gornik, O., Tjora, E.   +99 more
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iLDA‐SGCN: Identifying Associations Between Age‐Related Diseases and Long Non‐Coding RNAs Using Dual Graph Convolutional Networks

Aging Cell, Volume 25, Issue 6, June 2026.
iLDA‐SGCN integrates singular value decomposition and dual graph convolutional networks to predict lncRNA‐disease associations. It achieves superior performance on two benchmark datasets and identifies 33 candidate lncRNAs across 8 age‐related diseases.
Yu Guo, Shizheng Qiu, Zhishuai Zhang, Jirui Guo, Haozheng Liang, Huanyu You, Fengjuan Lu, Yanwei Xu, Yang Hu   +8 more
wiley   +1 more source

Metamorphosis and lncRNAs: A Close Relationship

genesis, Volume 64, Issue 2, April 2026.
ABSTRACT The classical definition of metamorphosis is a post‐embryonic transformation, such as from a tadpole to a froglet. However, recent studies suggest this process occurs to some degree in all vertebrates, as the underlying endocrine and molecular pathways are highly conserved. With the advent of high‐throughput sequencing, transcriptomic data for
H. Herrera‐Orozco, H. A. Pérez‐Mendoza   +1 more
wiley   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

MicroRNA-886 suppresses osteosarcoma cell proliferation and its maturation is suppressed by long non-coding RNA OXCT1-AS1

, 2022
This study aimed to investigate the roles of microRNA-886 (miR-886) and long non-coding RNA (lncRNA) OXCT1-AS1 in osteosarcoma (OS). We predicted that they might interact with each other.
Han Liu (288039), Wen Dai (1607932)
core   +1 more source