Results 41 to 50 of about 8,814 (196)

HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

eLife, 2018
The biological properties of pancreatic cancer stem cells (PCSCs) remain incompletely defined and the central regulators are unknown. By bioinformatic analysis of a human PCSC-enriched gene signature, we identified the transcription factor HNF1A as a ...
Ethan V Abel, Masashi Goto, Brian Magnuson, Saji Abraham, Nikita Ramanathan, Emily Hotaling, Anthony A Alaniz, Chandan Kumar-Sinha, Michele L Dziubinski, Sumithra Urs, Lidong Wang, Jiaqi Shi, Meghna Waghray, Mats Ljungman, Howard C Crawford, Diane M Simeone   +15 more
doaj   +1 more source

Traditional clinical criteria outperform high-sensitivity C-reactive protein for the screening of hepatic nuclear factor 1 alpha maturity-onset diabetes of the young among young Asians with diabetes

Therapeutic Advances in Endocrinology and Metabolism, 2018
Background: Young adults with diabetes in Asia represent a heterogeneous group. Using traditional clinical criteria to preselect individuals for testing for maturity-onset diabetes of the young (MODY) may exclude a large proportion from testing.
Suresh Rama Chandran, Jaydutt Bhalshankar, Rashida Farhad Vasanwala, Yi Zhao, Katharine R. Owen, Daphne Su-Lyn Gardner   +5 more
doaj   +1 more source

Granuloma annulare and necrobiosis lipoidica in a patient with HNF1A-MODY

Archives of Endocrinology and Metabolism, 2022
Maturity-onset diabetes of the young (MODY) is a heterogeneous group of monogenic forms of diabetes mellitus with distinct clinical features. Clinical dermatological phenotypes in MODY patients are very rare in literature. This report describes a patient with HNF1A-MODY presenting with necrobiosis lipoidica (NL) and granuloma annulare (GA).
Gabriela Irene Garcia Brandes, Renata Peixoto-Barbosa, Ana Paula Gomes Meski, Fernando M. A. Giuffrida, André F. Reis   +4 more
openaire   +3 more sources

Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency

Communications Biology, 2022
hPSCs model of Maturity Onset Diabetes of the Young caused by mutations in the transcription factor HNF1A (HNF1A-MODY), regulates the expression of genes required for the formation of dense-core insulin granules and calcium-dependent insulin secretion ...
Bryan J. González, Haoquan Zhao, Jacqueline Niu, Damian J. Williams, Jaeyop Lee, Chris N. Goulbourne, Yuan Xing, Yong Wang, Jose Oberholzer, Maria H. Blumenkrantz, Xiaojuan Chen, Charles A. LeDuc, Wendy K. Chung, Henry M. Colecraft, Jesper Gromada, Yufeng Shen, Robin S. Goland, Rudolph L. Leibel, Dieter Egli   +18 more
doaj   +1 more source

Figure S1, Figure S2 and Table S1 from EGR1-Mediated Transcription of lncRNA-HNF1A-AS1 Promotes Cell-Cycle Progression in Gastric Cancer

, 2018
Figure S1 showed that the overexpression and knockdown efficiency of HNF1A-AS1 in both GC cells and the proliferation of GC cells transfected with SI-HNF1A-AS1-2 were inhibited.
Peng Gao (35465), Hai-Ting Liu (9083636), Ran-Ran Ma (6468101), Sen Liu (438456), Lei Liu (5074)   +4 more
core   +1 more source

Molecular Diagnosis of Monogenic Diabetes and Clinical/Laboratory Features in Turkish Children

JCRPE, 2021
Objective:Monogenic diabetes is a heterogeneous disease that causes functional problems in pancreatic beta cells and hyperglycemia. The aim of this study was to determine the clinical and laboratory features, the admission characteristics and ...
Damla Gökşen, Ediz Yeşilkaya, Samim Özen, Yılmaz Kor, Erdal Eren, Özlem Korkmaz, Merih Berberoğlu, Gülay Karagüzel, Eren Er, Ayhan Abacı, Olcay Evliyaoğlu, Emine Demet Akbaş, Edip Ünal, Semih Bolu, Özlem Nalbantoğlu, Ahmet Anık, Meltem Tayfun, Muammer Büyükinan, Saygın Abalı, Gülay Can Yılmaz, Deniz Kör, Elif Söbü, Zeynep Şıklar, Recep Polat, Şükran Darcan   +24 more
doaj   +1 more source

The New Role of HNF1A-NAS1/miR-214/INHBA Signaling Axis in Colorectal Cancer

Frontiers in Bioscience-Landmark, 2023
Background: Colorectal cancer (CRC) is the third most common cancer and one of the leading causes of death worldwide. Seriously threatens human life and health.
Xuan Zhang, Tao Wu, Rujia Qin, Xinyi Cai, Yongchun Zhou, Xiaoxiong Wang, Zhongjun Shang, Guoyu Li, Renfang Yang, Chao Dong, Jinsha Li, Yongping Ren, Rong Ding, Yunfeng Li   +13 more
doaj   +1 more source

Diagnosis and Treatment of Monogenic Forms of Diabetes Mellitus: Focus on Mody-Diabetes

Архивъ внутренней медицины, 2022
Maturity-Onset Diabetes of the Young (MODY) is the most common form of monogenic diabetes resulting from a single gene mutation. It is characterized by mild hyperglycemia, autosomal dominant inheritance, early onset diabetes (<25 years), persistence ...
K. A. Aitbaev, I. T. Murkamilov, Zh. A. Murkamilova, V. V. Fomin, I. o Kudaibergenova, F. A. Yusupov   +5 more
doaj   +1 more source

Association study of HNF1A in women with polycystic ovary syndrome [PDF]

Journal of Assisted Reproduction and Genetics, 2017
This study aims to ascertain whether an association exists between hepatocyte nuclear factor 1 alpha (HNF1A) and polycystic ovary syndrome (PCOS).One thousand one hundred thirty-eight PCOS and 1125 healthy control Han Chinese women were recruited from Reproductive Hospital Affiliated to Shandong University. Serum hormone, blood lipid level, and genomic
Yue, Lv, Changfa, Sun, Ye, Tian, Shigang, Zhao, Yuehong, Bian, Lei, Cheng, Mei, Sun, Hong-Bin, Liu, Han, Zhao, Jinlong, Ma   +9 more
openaire   +2 more sources

Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case–control study in the Tunisian population and a meta-analysis

Diabetology & Metabolic Syndrome, 2022
Background Variants in the Hepatocyte Nuclear Factor 1 Alpha gene (HNF1A) are associated with lipoproteins levels and type 2 diabetes. In this study, we aimed to assess the association of HNF1A gene and haplotypes with the metabolic syndrome (MetS) and ...
Hamza Dallali, Meriem Hechmi, Imane Morjane, Sahar Elouej, Haifa Jmel, Yosra Ben Halima, Abdelmajid Abid, Afef Bahlous, Abdelhamid Barakat, Henda Jamoussi, Sonia Abdelhak, Rym Kefi   +11 more
doaj   +1 more source