Results 31 to 40 of about 8,539 (162)

Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case–control study in the Tunisian population and a meta-analysis

Diabetology & Metabolic Syndrome, 2022
Background Variants in the Hepatocyte Nuclear Factor 1 Alpha gene (HNF1A) are associated with lipoproteins levels and type 2 diabetes. In this study, we aimed to assess the association of HNF1A gene and haplotypes with the metabolic syndrome (MetS) and ...
Hamza Dallali, Meriem Hechmi, Imane Morjane, Sahar Elouej, Haifa Jmel, Yosra Ben Halima, Abdelmajid Abid, Afef Bahlous, Abdelhamid Barakat, Henda Jamoussi, Sonia Abdelhak, Rym Kefi   +11 more
doaj   +1 more source

Molecular Diagnosis of Monogenic Diabetes and Clinical/Laboratory Features in Turkish Children

JCRPE, 2021
Objective:Monogenic diabetes is a heterogeneous disease that causes functional problems in pancreatic beta cells and hyperglycemia. The aim of this study was to determine the clinical and laboratory features, the admission characteristics and ...
Damla Gökşen, Ediz Yeşilkaya, Samim Özen, Yılmaz Kor, Erdal Eren, Özlem Korkmaz, Merih Berberoğlu, Gülay Karagüzel, Eren Er, Ayhan Abacı, Olcay Evliyaoğlu, Emine Demet Akbaş, Edip Ünal, Semih Bolu, Özlem Nalbantoğlu, Ahmet Anık, Meltem Tayfun, Muammer Büyükinan, Saygın Abalı, Gülay Can Yılmaz, Deniz Kör, Elif Söbü, Zeynep Şıklar, Recep Polat, Şükran Darcan   +24 more
doaj   +1 more source

The New Role of HNF1A-NAS1/miR-214/INHBA Signaling Axis in Colorectal Cancer

Frontiers in Bioscience-Landmark, 2023
Background: Colorectal cancer (CRC) is the third most common cancer and one of the leading causes of death worldwide. Seriously threatens human life and health.
Xuan Zhang, Tao Wu, Rujia Qin, Xinyi Cai, Yongchun Zhou, Xiaoxiong Wang, Zhongjun Shang, Guoyu Li, Renfang Yang, Chao Dong, Jinsha Li, Yongping Ren, Rong Ding, Yunfeng Li   +13 more
doaj   +1 more source

Traditional clinical criteria outperform high-sensitivity C-reactive protein for the screening of hepatic nuclear factor 1 alpha maturity-onset diabetes of the young among young Asians with diabetes

Therapeutic Advances in Endocrinology and Metabolism, 2018
Background: Young adults with diabetes in Asia represent a heterogeneous group. Using traditional clinical criteria to preselect individuals for testing for maturity-onset diabetes of the young (MODY) may exclude a large proportion from testing.
Suresh Rama Chandran, Jaydutt Bhalshankar, Rashida Farhad Vasanwala, Yi Zhao, Katharine R. Owen, Daphne Su-Lyn Gardner   +5 more
doaj   +1 more source

Monogenic Diabetes: Genetic Insight and Precision Therapeutics in the Management of MODY

Exon
A monogenic diabetes, specifically, the Maturity-onset diabetes of the young (MODY) is the consequence of the single-gene mutations that are responsible for transcription factors such as HNF1A and GCK taking effect on the insulin synthesis, glucose ...
Gayathri Venkatesan, Kala vetha Kumari, Ariya S S, Princy Vijayababu   +3 more
doaj   +1 more source

Figure S1, Figure S2 and Table S1 from EGR1-Mediated Transcription of lncRNA-HNF1A-AS1 Promotes Cell-Cycle Progression in Gastric Cancer

, 2018
Figure S1 showed that the overexpression and knockdown efficiency of HNF1A-AS1 in both GC cells and the proliferation of GC cells transfected with SI-HNF1A-AS1-2 were inhibited.
Peng Gao (35465), Hai-Ting Liu (9083636), Ran-Ran Ma (6468101), Sen Liu (438456), Lei Liu (5074)   +4 more
core   +1 more source

Role of rare HNF1A variants function in monogenic and type 2 diabetes [PDF]

, 2018
Variants in the transcription factor gene HNF1A have been identified in subjects with maturity-onset diabetes of the young (MODY) type 3, type 2 diabetes, as well as in children with apparent type 1 diabetes.
Najmi, Laeya Abdoli
core   +1 more source

MYC‐activated lncRNA HNF1A‐AS1 overexpression facilitates glioma progression via cooperating with miR‐32‐5p/SOX4 axis

Cancer Medicine, 2020
Mounting literatures have revealed the crucial effects of long noncoding RNA (lncRNA) in various cancers, including glioma. HNF1A‐AS1, a novel lncRNA, is reported to modulate tumorigenesis and development of multiple cancers.
Jianheng Wu, Rong Li, Linfan Li, Yimian Gu, Hui Zhan, Changbao Zhou, Chuanhong Zhong   +6 more
doaj   +1 more source

Diagnosis and Treatment of Monogenic Forms of Diabetes Mellitus: Focus on Mody-Diabetes

Архивъ внутренней медицины, 2022
Maturity-Onset Diabetes of the Young (MODY) is the most common form of monogenic diabetes resulting from a single gene mutation. It is characterized by mild hyperglycemia, autosomal dominant inheritance, early onset diabetes (<25 years), persistence ...
K. A. Aitbaev, I. T. Murkamilov, Zh. A. Murkamilova, V. V. Fomin, I. o Kudaibergenova, F. A. Yusupov   +5 more
doaj   +1 more source

Evaluation of Long Non-Coding RNAs: HNF1A-AS1 and MVIH Expressions and Their Clinical Significance in Human Gastric Cancer [PDF]

Journal of Genetic Resources, 2020
Gastric cancer is one of the most common cancers in the world. Late diagnosis is the main cause of the high rate of treatment failure and death among patients with gastric cancer; therefore identifying the molecular basis of cancer initiation and ...
Hasan Rahimi-Tamandegani, Parvaneh Nikpour, Mojtaba Emadi Baygi   +2 more
doaj   +1 more source