Results 31 to 40 of about 8,814 (196)

The Common HNF1A Variant I27L is a Modifier of Age at Diabetes Diagnosis in HNF1A-MODY Individuals.

, 2018
There is wide variation in the age at diagnosis of diabetes in individuals with Maturity-Onset Diabetes of the Young (MODY) due to a mutation in the HNF1A gene.
JM Locke (21825998), C Saint-Martin (21320024), LW Harries (21821876), S Ellard (13734760), SA Sharp (21883175), AT Hattersley (7655273), TW Laver (21853583), C Bellanné-Chantelot (21883178), KA Patel (21320144), AR Wood (7715282), MN Weedon (7655270)   +10 more
core   +6 more sources

Long non-coding RNA HNF1A-AS1 induces 5-FU resistance of gastric cancer through miR-30b-5p/EIF5A2 pathway

Translational Oncology, 2022
Background: Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide and chemoresistance is a major cause for its poor prognosis. Long non-coding RNAs (lncRNAs) are associated with cancer chemoresistance.
Lin Jiang, Yingjing Zhang, Pengfei Su, Zhiqiang Ma, Xin Ye, Weiming Kang, Yuqin Liu, Jianchun Yu   +7 more
doaj   +1 more source

EGR1 modulated LncRNA HNF1A-AS1 drives glioblastoma progression via miR-22-3p/ENO1 axis

Cell Death Discovery, 2021
Accumulating evidences revealed that long noncoding RNAs (lncRNAs) have been participated in cancer malignant progression, including glioblastoma multiforme (GBM).
Chunchun Ma, Hongliang Wang, Gang Zong, Jie He, Yuyang Wang, Fan Yang, Zhihao Yang, Erbao Bian, Bing Zhao   +8 more
doaj   +1 more source

Monogenic diabetes: a new pathogenic variant of HNF1A gene [PDF]

BMJ Case Reports, 2021
Maturity onset diabetes of the young defines a diabetes mellitus subtype, with no insulin resistance or autoimmune pancreatic β-cells dysfunction, that occurs by mutation in a single gene. A 13-year-old girl hospitalised due to hyperglycemia plus glycosuria without ketosis, and with normal glycated haemoglobin of 6.8%.
Oliveira, Raquel Vilela, Bernardo, Teresa, Martins, Sandrina, Sequeira, Ana   +3 more
openaire   +2 more sources

HNF1A inhibition induces the resistance of pancreatic cancer cells to gemcitabine by targeting ABCB1Research in context

EBioMedicine, 2019
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor prognosis, and gemcitabine-based chemotherapy remains an effective option for the majority of PDAC patients. Hepatocyte nuclear factor 1α (HNF1A) is a tumor-suppressor
Yanan Lu, Dongni Xu, Jintao Peng, Zhaofan Luo, Chujie Chen, Yuqing Chen, Huimou Chen, Minghui Zheng, Peihong Yin, Zhi Wang   +9 more
doaj   +1 more source

Molecular and clinical assessment of maturity-onset diabetes of the young revealed low mutational rate in Moroccan families

International Journal of Pediatrics & Adolescent Medicine, 2022
Background: Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes characterized by autosomal dominant inheritance. To offer an adequate patient management and therapeutic treatment for MODY patients, in addition to an early ...
Said Trhanint, Laila Bouguenouch, Sana Abourazzak, Hanan El Ouahabi, Hanane Latrech, Salma Benyakhlef, Bahia Bennani, Ihssane El Bouchikhi, Fatima Zahra Moufid, Karim Ouldim, Lahsen El Ghadraoui, Nadia Maazouzi   +11 more
doaj   +1 more source

Hepatocyte nuclear factor 1A (HNF1A) as a possible tumor suppressor in pancreatic cancer. [PDF]

PLoS ONE, 2015
HNF1A (Hepatocyte nuclear factor 1 alpha) is a transcription factor that is known to regulate pancreatic differentiation and maintain homeostasis of endocrine pancreas.
Zhaofan Luo, Yanan Li, Huamin Wang, Jason Fleming, Min Li, Yaan Kang, Ran Zhang, Donghui Li   +7 more
doaj   +1 more source

Mutations in HNF1A Result in Marked Alterations of Plasma Glycan Profile [PDF]

, 2013
A recent genome-wide association study identified hepatocyte nuclear factor 1-α (HNF1A) as a key regulator of fucosylation. We hypothesized that loss-of-function HNF1A mutations causal for maturity-onset diabetes of the young (MODY) would display altered
Klimes, Iwar, Rudd, Pauline M., Muzinic, Ana, Reynolds, Rebecca M., McCarthy, Mark I, Redzic, I., Mughal, Saima A, Redzic, Irma, Stanik, Juraj, Kattla, Jayesh J., Zgaga, Lina, Rudan, Igor, Kokic, I., Primorac, Dragan, Owen, Katharine R, Tjora, Erling, Strachan, M. W. J., Huffman, Jennifer E., Pucic, Maja, Wilson, J. F., Gasperikova, Daniela, Hassanali, N., Adamczyk, Barbara, Wilson, James F, Hayward, C., Mughal, S. A., Hayward, Caroline, Adamczyk, B., Pedersen, Oluf B, Klimes, I., Campbell, Harry, Muzinic, A., Rudd, Pauline M, Gyllensten, Ulf, Hastie, Nicholas D, Wright, A. F., Wild, S. H., Nielsen, Trine, Thanabalasingham, G., Strachan, Mark W J, Bennett, Amanda J, Lauc, Gordan, Reynolds, R. M., Pucic, M., Bennett, Amanda J., Gloyn, A. L., Mughal, Saima A., Novokmet, Mislav, Strachan, Mark W. J., Zgaga, L., Wright, Alan F., Wright, Alan F, Polasek, Ozren, Polasek, O., Njolstad, P. R., Owen, K. R., McCarthy, M. I., Njolstad, Pal R., Njølstad, Pål R, Wild, Sarah H; id_orcid, Kattla, Jayesh J, Huffman, J. E., Gyllensten, Ulf,, Campbell, Harry; id_orcid, Nielsen, T., Stanik, J., Rudd, P. M., Wild, Sarah H, Gasperikova, D., Kolcic, Ivana, Novokmet, M., Rudan, I., Hansen, Torben, Reynolds, Rebecca M, Essafi, A., Primorac, D., Wilson, James F., Kattla, J. J., Thanabalasingham, Gaya, Hastie, N. D., Wild, Sarah H., Gyllensten, U., Gloyn, Anna L, Campbell, H., Gloyn, Anna L., Owen, Katharine R., Bennett, A. J., Hassanali, Neelam, Lauc, G., Wilson, James F; id_orcid, Essafi, Abdelkader, Huffman, Jennifer E, Kokic, Ivana, Hayward, Caroline; id_orcid, Pedersen, Oluf B., Hastie, Nicholas D., McCarthy, Mark I., Gornik, Olga, Gornik, O., Tjora, E.   +99 more
core   +1 more source

Fucosylated AGP glycopeptides as biomarkers of HNF1A-Maturity onset diabetes of the young [PDF]

, 2022
Aims: We previously demonstrated that antennary fucosylated N-glycans on plasma proteins are regulated by HNF1A and can identify cases of Maturity-Onset Diabetes of the Young caused by HNF1A variants (HNF1A-MODY).
Owen, Katharine R., Gornik, Olga, Novokmet, Mislav, Štambuk, Tamara, Tjora, Erling, Pape Medvidović, Edita, Njølstad, Pål Rasmus, Gasperikova, Daniela, Stanik, Juraj, Juszczak, Agata, Keser, Toma, Tijardović, Marko, Lauc, Gordan, Katharine R. Owen, Agata Juszczak, Edita Pape Medvidović, Juraj Stanik, Tamara Štambuk, Olga Gornik, Daniela Gasperikova, Marko Tijardović, Pål Rasmus Njølstad, Mislav Novokmet, Gordan Lauc, Toma Keser, Erling Tjora   +25 more
core   +1 more source

Meta-analysis of HNF1A-MODY3 variants among human population [PDF]

Journal of Diabetes & Metabolic Disorders, 2021
Abstract BackgroundPreviously, numerous case-control studies have highlighted variants responsible for Maturity onset diabetes of young (MODY). However, these studies have been conducted among diverse populations and hence yielded contradictory results.
Rachna Behl, Nishtha Malhotra, Vinay Joshi, Shruti Poojary, Sanniya Middha, Shalini Gupta, Arinola B. Olaonipekun, Ikechukwu Okoye, Bhushan Wagh, Dibyendu Biswas, Chukwuemelie Aginah, Bhavya Saini, Chinaza Nwanya, Sopuluchukwu Ugwu, Anthony Modupe, Xuanyu S. Fang, Foluso Ogunfile, Abdulrahman Tudu Ibrahim   +17 more
openaire   +4 more sources