Results 11 to 20 of about 8,539 (162)

Circulating CD36 is reduced in HNF1A-MODY carriers. [PDF]

PLoS ONE, 2013
INTRODUCTION: Premature atherosclerosis is a significant cause of morbidity and mortality in type 2 diabetes mellitus. Maturity onset diabetes of the young (MODY) accounts for approximately 2% of all diabetes, with mutations in the transcription factor ...
Siobhan Bacon, Ma P Kyithar, Jasmin Schmid, Andre Costa Pozza, Aase Handberg, Maria M Byrne   +5 more
doaj   +2 more sources

Variants influencing age at diagnosis of HNF1A-MODY [PDF]

Molecular Medicine, 2022
Background HNF1A-MODY is a monogenic form of diabetes caused by variants in the HNF1A gene. Different HNF1A variants are associated with differences in age of disease onset, but other factors are postulated to influence this trait.
Agnieszka H. Ludwig-Słomczyńska, Michał T. Seweryn, Piotr Radkowski, Przemysław Kapusta, Julita Machlowska, Stepanka Pruhova, Daniela Gasperikova, Christine Bellanne-Chantelot, Andrew Hattersley, Balamurugan Kandasamy, Lisa Letourneau-Freiberg, Louis Philipson, Alessandro Doria, Paweł P. Wołkow, Maciej T. Małecki, Tomasz Klupa   +15 more
doaj   +2 more sources

The Common HNF1A Variant I27L is a Modifier of Age at Diabetes Diagnosis in HNF1A-MODY Individuals. [PDF]

, 2018
There is wide variation in the age at diagnosis of diabetes in individuals with Maturity-Onset Diabetes of the Young (MODY) due to a mutation in the HNF1A gene.
JM Locke (21825998), C Saint-Martin (21320024), LW Harries (21821876), S Ellard (13734760), SA Sharp (21883175), AT Hattersley (7655273), TW Laver (21853583), C Bellanné-Chantelot (21883178), KA Patel (21320144), AR Wood (7715282), MN Weedon (7655270)   +10 more
core   +8 more sources

Novel insights into genetics and clinics of the HNF1A-MODY

Endocrine Regulations, 2019
MODY (Maturity Onset Diabetes of the Young) is a type of diabetes resulting from a pathogenic effect of gene mutations. Up to date, 13 MODY genes are known. Gene HNF1A is one of the most common causes of MODY diabetes (HNF1A-MODY; MODY3).
Valkovicova Terezia, Skopkova Martina, Stanik Juraj, Gasperikova Daniela   +3 more
doaj   +2 more sources

Funciones in vivo del regulador transcripcional HNF1a (MODY3) [PDF]

, 2007
[spa] Las mutaciones en el factor de transcripción HNF1a son la causa más frecuente de diabetes tipo MODY. HNF1a está implicado en una compleja red transcripcional responsable de la diferenciación y función de la célula beta.
Fernández de Luco Hernández, Reina
core   +7 more sources

New clinical screening strategy to distinguish HNF1A variant-induced diabetes from young early-onset type 2 diabetes in a Chinese population

BMJ Open Diabetes Research & Care, 2020
ObjectiveMaturity-onset diabetes of the young caused by hepatocyte nuclear factor-1 alpha (HNF1A) variants (HNF1A-MODY) is a common form of monogenetic diabetes.
Yumin Ma, Siqian Gong, Xirui Wang, Xiaoling Cai, Xinhua Xiao, Weijun Gu, Jinkui Yang, Liyong Zhong, Jianzhong Xiao, Simin Zhang, Xianghai Zhou, Lingli Zhou, Yingying Luo, Qian Ren, Xiuting Huang, Xueying Gao, Qiuping Wang, Mengdie Hu, Xueyao Han   +18 more
doaj   +1 more source

HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F1

Scientific Reports, 2021
POU5F1-expressing cells can self-renew and differentiate, contributing to metastasis formation in colorectal cancer (CRC), but it plays an important role in normal pluripotent stem cells.
Shiki Fujino, Norikatsu Miyoshi, Aya Ito, Masayoshi Yasui, Chu Matsuda, Masayuki Ohue, Mamoru Uemura, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi   +9 more
doaj   +1 more source

HNF1a-induced promoter activities of Akr1c12 and 13 in HEK293 cells.

, 2021
HEK293 cells were co-transfected with HNF1a and luciferase reporter construct containing Akr1c12 (-1115 to -1) or Akr1c13 (-1006 to -1) promoter region. All values represent mean ± SEM. (PDF)
Domenico Accili (185429), Jinsook Son (11766939), Yasutaka Miyachi (3178986), Taiyi Kuo (2863205)   +3 more
core   +1 more source

Integrated bioinformatic analysis of HNF1A in human cancers

Journal of International Medical Research, 2021
Objectives Cancer is a threat to human health, and many molecules are involved in the transformation of malignant cells. Hepatocyte nuclear factor 1A (HNF1A) is an important transcription factor that regulates multiple biological processes.
Enfan Zhang, Xi Huang, Jingsong He
doaj   +1 more source

Altered cortisol metabolism in individuals with HNF1A-MODY [PDF]

, 2020
Objective and context: Maturity onset diabetes of the young due to variants in HNF1A (HNF1A‐MODY) is the most common form of monogenic diabetes. Individuals with HNF1A‐MODY usually have a lean phenotype which contrasts with type 2 diabetes (T2DM).
Katharine R. Owen, Zaki K. Hassan‐Smith, Gilligan, Lorna, Agata Juszczak, Hughes, Beverly, Owen, Katharine R., Hassan-Smith, Zaki, Arlt, Wiebke, Tomlinson, Jeremy, Lorna C. Gilligan, Wiebke Arlt, McCarthy, Mark I, Beverly A. Hughes, Mark I. McCarthy, Jeremy W. Tomlinson, Juszczak, Agata   +15 more
core   +3 more sources