Results 1 to 10 of about 7,146 (116)

Integrated transcriptome and proteome analyses unveil cytoskeletal alterations in an endothelial model of monogenic diabetes [PDF]

Genome Medicine
Background HNF1A-MODY is a subtype of monogenic diabetes caused by mutations in the hepatocyte nuclear factor-1 homeobox A (HNF1A) gene. While the role of HNF1A in pancreatic beta cells has been extensively studied, its role in other cell types, such as ...
Dawid Skoczek, Damian Kloska, Marta Targosz-Korecka, Krzysztof Szade, Artur Biela, Jerzy Hohendorff, Marian Babincak, Aleksandra Kopacz, Maciej T. Malecki, Jacek Stepniewski, Neli Kachamakova-Trojanowska   +10 more
doaj   +2 more sources

Progressive HNF1A-MODY pathophysiology revealed by a translational mouse model [PDF]

JCI Insight
HNF1A-MODY, the most common monogenic diabetes, exhibits progressive β cell dysfunction, but existing mouse models fail to recapitulate human disease progression, limiting understanding of pathogenic mechanisms.
Isaline Louvet, Ana Acosta-Montalvo, Chiara Saponaro, Maria Moreno-Lopez, Sana Douffi, Abdelkrim El Karchaoui, Gianni Pasquetti, Julien Thevenet, Nathalie Delalleau, Valery Gmyr, Paolo Giacobini, Stéphanie Espiard, Julie Kerr-Conte, François Pattou, Adrian Liston, Caroline Bonner   +15 more
doaj   +2 more sources

Case Report: Identification of a HNF1A exons 1–10 heterozygous deletion in a Chinese MODY family [PDF]

Frontiers in Endocrinology
BackgroundMaturity-onset diabetes of the young (MODY) is an autosomal dominant monogenic diabetes, with HNF1A-MODY (MODY3) being a common subtype. Standard genetic testing for MODY often focuses on sequencing, which can lead to the misdiagnosis of cases ...
Mengyun Lei, Mei Xue, Huawei Wang, Zhe Dai, Jun Tang   +4 more
doaj   +2 more sources

LncRNA HNF1A-AS1 promotes prostate cancer progression via the miR-138-5p/KDM6B axis [PDF]

Biology Direct
Background Prostate cancer (PCa) is a widespread malignancy with poor prognosis in advanced stages. However, the role of long non-coding RNA (lncRNA) HNF1A-AS1 in PCa progression and its underlying mechanisms remain largely unclear.
Tingxuan Lv, Kexiang Wang, Weicai Chang, Feng Feng   +3 more
doaj   +2 more sources

m⁶A Modification of Long Non-Coding RNA HNF1A-AS1 Facilitates Cell Cycle Progression in Colorectal Cancer via IGF2BP2-Mediated CCND1 mRNA Stabilization

Cells, 2022
Background: Long non-coding RNAs modulate tumor occurrence through different molecular mechanisms. It had been reported that HNF1A-AS1 (HNF1A Antisense RNA 1) was differently expressed in multiple tumors.
Yibo Bian, Yang Wang, Shufen Xu, Zhishuang Gao, Chao Li, Zongyao Fan, Jie Ding, Keming Wang   +7 more
doaj   +1 more source

HNF1A binds and regulates the expression of SLC51B to facilitate the uptake of estrone sulfate in human renal proximal tubule epithelial cells

Cell Death and Disease, 2023
Renal defects in maturity onset diabetes of the young 3 (MODY3) patients and Hnf1a -/- mice suggest an involvement of HNF1A in kidney development and/or its function.
Jun Wei Chan, Claire Wen Ying Neo, Soumita Ghosh, Hyungwon Choi, Su Chi Lim, E. Shyong Tai, Adrian Kee Keong Teo   +6 more
doaj   +1 more source

HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F1

Scientific Reports, 2021
POU5F1-expressing cells can self-renew and differentiate, contributing to metastasis formation in colorectal cancer (CRC), but it plays an important role in normal pluripotent stem cells.
Shiki Fujino, Norikatsu Miyoshi, Aya Ito, Masayoshi Yasui, Chu Matsuda, Masayuki Ohue, Mamoru Uemura, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi   +9 more
doaj   +1 more source

New clinical screening strategy to distinguish HNF1A variant-induced diabetes from young early-onset type 2 diabetes in a Chinese population

BMJ Open Diabetes Research & Care, 2020
ObjectiveMaturity-onset diabetes of the young caused by hepatocyte nuclear factor-1 alpha (HNF1A) variants (HNF1A-MODY) is a common form of monogenetic diabetes.
Yumin Ma, Siqian Gong, Xirui Wang, Xiaoling Cai, Xinhua Xiao, Weijun Gu, Jinkui Yang, Liyong Zhong, Jianzhong Xiao, Simin Zhang, Xianghai Zhou, Lingli Zhou, Yingying Luo, Qian Ren, Xiuting Huang, Xueying Gao, Qiuping Wang, Mengdie Hu, Xueyao Han   +18 more
doaj   +1 more source

Integrated bioinformatic analysis of HNF1A in human cancers

Journal of International Medical Research, 2021
Objectives Cancer is a threat to human health, and many molecules are involved in the transformation of malignant cells. Hepatocyte nuclear factor 1A (HNF1A) is an important transcription factor that regulates multiple biological processes.
Enfan Zhang, Xi Huang, Jingsong He
doaj   +1 more source

Circulating CD36 is reduced in HNF1A-MODY carriers. [PDF]

PLoS ONE, 2013
INTRODUCTION: Premature atherosclerosis is a significant cause of morbidity and mortality in type 2 diabetes mellitus. Maturity onset diabetes of the young (MODY) accounts for approximately 2% of all diabetes, with mutations in the transcription factor ...
Siobhan Bacon, Ma P Kyithar, Jasmin Schmid, Andre Costa Pozza, Aase Handberg, Maria M Byrne   +5 more
doaj   +1 more source