Results 21 to 30 of about 8,539 (162)

HNF1A-MODY Mutations in Nuclear Localization Signal Impair HNF1A-Import Receptor KPNA6 Interactions

, 2021
#nofulltext# --- Fareed, Fareed M. A. (Arel Author), Çapan Yalçın, Özlem (Arel Author)Mutations in hepatocyte nuclear factor (HNF)1A gene cause the most common form of Maturity-onset diabetes of the young (MODY), a monogenic subtype of diabetes mellitus.
Fareed, Fareed M. A., Korulu, Şirin, Capan, Ozlem Yalcin, Özbil, Mehmet, Çapan Yalçın, Özlem   +4 more
core   +1 more source

EGR1 modulated LncRNA HNF1A-AS1 drives glioblastoma progression via miR-22-3p/ENO1 axis

Cell Death Discovery, 2021
Accumulating evidences revealed that long noncoding RNAs (lncRNAs) have been participated in cancer malignant progression, including glioblastoma multiforme (GBM).
Chunchun Ma, Hongliang Wang, Gang Zong, Jie He, Yuyang Wang, Fan Yang, Zhihao Yang, Erbao Bian, Bing Zhao   +8 more
doaj   +1 more source

Hepatocyte nuclear factor 1A (HNF1A) as a possible tumor suppressor in pancreatic cancer. [PDF]

PLoS ONE, 2015
HNF1A (Hepatocyte nuclear factor 1 alpha) is a transcription factor that is known to regulate pancreatic differentiation and maintain homeostasis of endocrine pancreas.
Zhaofan Luo, Yanan Li, Huamin Wang, Jason Fleming, Min Li, Yaan Kang, Ran Zhang, Donghui Li   +7 more
doaj   +1 more source

HNF1A inhibition induces the resistance of pancreatic cancer cells to gemcitabine by targeting ABCB1Research in context

EBioMedicine, 2019
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor prognosis, and gemcitabine-based chemotherapy remains an effective option for the majority of PDAC patients. Hepatocyte nuclear factor 1α (HNF1A) is a tumor-suppressor
Yanan Lu, Dongni Xu, Jintao Peng, Zhaofan Luo, Chujie Chen, Yuqing Chen, Huimou Chen, Minghui Zheng, Peihong Yin, Zhi Wang   +9 more
doaj   +1 more source

The HNF1α-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1

Molecular Cancer, 2018
Background Our previous study has demonstrated that hepatocyte nuclear factor 1α (HNF1α) exerts potent therapeutic effects on hepatocellular carcinoma (HCC).
Chen-Hong Ding, Chuan Yin, Shi-Jie Chen, Liang-Zhi Wen, Kai Ding, Shu-Juan Lei, Jin-Pei Liu, Jian Wang, Kai-xian Chen, Hua-liang Jiang, Xin Zhang, Cheng Luo, Wei-Fen Xie   +12 more
doaj   +1 more source

Regulation of HNF1A in human pancreatic β-cells

, 2022
HNF1A is a transcription factor important for normal pancreatic β-cell function. Heterozygous mutations in HNF1A result in monogenic diabetes. Furthermore, rare and common variants in HNF1A influence Type 2 diabetes risk.
Font Cunill, Berta
core   +1 more source

Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency

Communications Biology, 2022
hPSCs model of Maturity Onset Diabetes of the Young caused by mutations in the transcription factor HNF1A (HNF1A-MODY), regulates the expression of genes required for the formation of dense-core insulin granules and calcium-dependent insulin secretion ...
Bryan J. González, Haoquan Zhao, Jacqueline Niu, Damian J. Williams, Jaeyop Lee, Chris N. Goulbourne, Yuan Xing, Yong Wang, Jose Oberholzer, Maria H. Blumenkrantz, Xiaojuan Chen, Charles A. LeDuc, Wendy K. Chung, Henry M. Colecraft, Jesper Gromada, Yufeng Shen, Robin S. Goland, Rudolph L. Leibel, Dieter Egli   +18 more
doaj   +1 more source

HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A [PDF]

, 2022
The biological purpose of long non-coding RNAs (lncRNAs) is poorly understood. Haploinsufficient mutations in HNF1A homeobox A (HNF1A), encoding a homeodomain transcription factor, cause diabetes mellitus.
Vas, Matías G. de, Gonzalez-Franco, Roser, Heyn, Holger, Ravassard, Philppe, Balboa, Diego, Garcia-Hurtado, Javier, De Vas, Matías G, Gonzalez Franco, Roser, Beucher, Anthony, Bernal, Aina, Miguel-Escalada, Irene, Vargiu, Pierfrancesco, De Vas, Matías G., Angel Maestro, Miguel, Miguel Escalada, Irene, De Vas, Matias, Maestro, Miguel Angel, Ferrer, Jorge, Ravassard, Philippe, Ortega, Sagrario   +19 more
core   +1 more source

HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

eLife, 2018
The biological properties of pancreatic cancer stem cells (PCSCs) remain incompletely defined and the central regulators are unknown. By bioinformatic analysis of a human PCSC-enriched gene signature, we identified the transcription factor HNF1A as a ...
Ethan V Abel, Masashi Goto, Brian Magnuson, Saji Abraham, Nikita Ramanathan, Emily Hotaling, Anthony A Alaniz, Chandan Kumar-Sinha, Michele L Dziubinski, Sumithra Urs, Lidong Wang, Jiaqi Shi, Meghna Waghray, Mats Ljungman, Howard C Crawford, Diane M Simeone   +15 more
doaj   +1 more source

Molecular and clinical assessment of maturity-onset diabetes of the young revealed low mutational rate in Moroccan families

International Journal of Pediatrics & Adolescent Medicine, 2022
Background: Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes characterized by autosomal dominant inheritance. To offer an adequate patient management and therapeutic treatment for MODY patients, in addition to an early ...
Said Trhanint, Laila Bouguenouch, Sana Abourazzak, Hanan El Ouahabi, Hanane Latrech, Salma Benyakhlef, Bahia Bennani, Ihssane El Bouchikhi, Fatima Zahra Moufid, Karim Ouldim, Lahsen El Ghadraoui, Nadia Maazouzi   +11 more
doaj   +1 more source