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Topological examination of the bacteriophage lambda S holin by EPR spectroscopy
Biophysical Journal, 2022The S protein from bacteriophage lambda is a three-helix transmembrane protein produced by the prophage which accumulates in the host membrane during late gene expression. It is responsible for the first step in lysing the host cell at the end of the viral life cycle by multimerizing together to form large pores which permeabilize the host membrane to ...
Andrew K, Morris +3 more
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Functional analysis of the phage T4 holin in a λ context
Molecular Genetics and Genomics, 2001Phage lambda hybrids were constructed by inserting the t gene of phage T4 in place of the lambda holin gene, S. Induction of the hybrid phage resulted in lysis that was just as abrupt as, but occurred much earlier in the vegetative cycle than, that obtained with lambda, indicating that t is indeed a holin gene. Moreover, it was possible to impose lysis
E, Ramanculov, R, Young
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Biochemical and Genetic Characterization of Bacteriophage Holins
, 2013 Bacteriophages infect and kill bacterial cells. During the infection cycle, a phage attaches to the host cell surface, then ejects its DNA into the cytoplasm, where its progenies are subsequently assembled.
To, Kam Ho
exaly +1 more source
Protein Peptide Letters
Phage therapy has attracted attention as a possible alternative treatment for multi-drug resistance (MDR) infections in recent years. The lytic bacteriophages encode proteins for bacterial host envelope rupture.
S. Samir
semanticscholar +1 more source
Phage therapy has attracted attention as a possible alternative treatment for multi-drug resistance (MDR) infections in recent years. The lytic bacteriophages encode proteins for bacterial host envelope rupture.
S. Samir
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A coupling process for improving purity of bacterial minicells by holin/lysin
Journal of Microbiological Methods, 2011Drug and gene delivery systems using bacterial minicells have attracted much attention. Here we attempted to enhance the yield and purity of the minicells using a novel method in which autolysin induced in actively metabolizing parent cells led to autolysis. A two-step protocol coupling an autolysin (holin/lysin) step with a conventional centrifugation
So-Youn, Park +4 more
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How Transcriptional Bursting and mRNA Production Affect Precise Timing of Cell Lysis Phenomena.
Journal of Physical Chemistry BBacterial viruses infect bacterial cells and stimulate the production of holin proteins that accumulate in the cellular membranes. When the number of such proteins reaches a threshold, the membrane permeabilizes and the cell is destroyed in the process ...
Zhuoyan Lyu +2 more
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FEBS Letters
Gene gp52 of bacteriophage Phi11 encodes a putative holin (“GeneID:1258070”). Holins are bacteriophage proteins that control host cell lysis and determine the timing of the phage's infectious cycle.
Manideep Burra +3 more
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Gene gp52 of bacteriophage Phi11 encodes a putative holin (“GeneID:1258070”). Holins are bacteriophage proteins that control host cell lysis and determine the timing of the phage's infectious cycle.
Manideep Burra +3 more
semanticscholar +1 more source
Microbial Pathogenesis
BACKGROUND Acinetobacter baumannii is a typical extensively drug-resistant Gram-negative opportunistic pathogen. Bacteriophages and their encoded lytic proteins, such as endolysins and holins, represent a promising novel therapeutic approach ...
Hao-Yu Li +7 more
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BACKGROUND Acinetobacter baumannii is a typical extensively drug-resistant Gram-negative opportunistic pathogen. Bacteriophages and their encoded lytic proteins, such as endolysins and holins, represent a promising novel therapeutic approach ...
Hao-Yu Li +7 more
semanticscholar +1 more source
Al-Holin suomalaislapset eduskunnan täysistuntopuheenvuoroissa
2020unknown ...
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Sequence Analysis of Holins by Reduced Amino Acid Alphabet Model and PermutationApproaches
, 2016Konda Mani Saravanan
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