Results 1 to 10 of about 4,149 (194)

Endolysins Against Streptococci as an Antibiotic Alternative

Frontiers in Microbiology, 2022
Multi-drug resistance has called for a race to uncover alternatives to existing antibiotics. Phage therapy is one of the explored alternatives, including the use of endolysins, which are phage-encoded peptidoglycan hydrolases responsible for bacterial ...
Lionel Lian Aun In, Adelene Ai-Lian Song, Mas Jaffri Masarudin   +2 more
exaly   +6 more sources

Thousands of Novel Endolysins Discovered in Uncultured Phage Genomes [PDF]

Frontiers in Microbiology, 2018
Bacteriophages express endolysins toward the end of their replication cycle to degrade the microbial cell wall from within, allowing viral progeny to be released. Endolysins can also degrade the prokaryotic cell wall from the outside, thus have potential
Felipe H Coutinho, Francisco Rodriguez-Valera, Iris Fernández-Ruiz   +2 more
exaly   +4 more sources

First experimentally characterised Proteus phage endolysins have distinct metal cofactor dependencies [PDF]

Applied Microbiology and Biotechnology
Proteus mirabilis is a Gram-negative uropathogenic bacterial species responsible for many catheter-associated urinary tract infections (CAUTIs). Due to the growing rates of antimicrobial resistance among CAUTI pathogens, novel antimicrobial solutions are
Akash Shambharkar, Thomas P. Thompson, Laura A. McClenaghan, Katie J. J. Brown, Stephen A. Kelly, Brendan F. Gilmore, Timofey Skvortsov   +6 more
doaj   +3 more sources

Polycationic nanopeptide-fused endolysins for the control of Mannheimia haemolytica [PDF]

Applied Microbiology and Biotechnology
Bovine respiratory disease (BRD) remains a major economic and animal health concern in cattle production, exacerbated by rising antimicrobial resistance and limited vaccine efficacy.
Sidra Moqaddes, Hechao Du, Jieting Lin, Jae Eun Hyun, Mawra Gohar, Alexei Savchenko, Kim Stanford, Brenda Ralston, Tim A. McAllister, Yan Dong Niu   +9 more
doaj   +2 more sources

Phage endolysins as alternative antimicrobials: mechanisms, clinical progress, and emerging resistance frameworks [PDF]

Frontiers in Microbiology
Phage endolysins are increasingly recognized as alternatives to antibiotics for mitigating the growing threat of antimicrobial resistance. Since their initial identification in the 1950s, phage endolysins have been extensively demonstrated to effectively
Haocong Qian, Yuxuan Zheng
doaj   +2 more sources

Inhalable bacteriophage endolysins: a novel therapeutic strategy for drug-resistant bacterial pulmonary infections – a comprehensive review [PDF]

Annals of Medicine
Background Pulmonary infections caused by multidrug-resistant (MDR) bacteria pose a severe global health threat with high mortality rates, especially in hospital-acquired pneumonia. The stagnation of new antibiotic development underscores the urgent need
Dongyan Ding, Hailing Duan, Fang Zhang, Xi Wang, Yijia Guo, Ruiping Tian, Xiaotian Dai, Haidong Li   +7 more
doaj   +2 more sources

Biofunctionalization of Endolysins With Oligosacharides: Formulation of Therapeutic Agents to Combat Multi-Resistant Bacteria and Potential Strategies for Their Application

Polysaccharides, 2022
In the aquaculture sector, the biofunctionalization of biomaterials is discussed using materials from algae and analyzed as a possible potential strategy to overcome the challenges that hinder the future development of the application of endolysins in ...
Alejandro Pérez-Larios, Jorge Alberto Sánchez-Burgos   +1 more
exaly   +3 more sources

The Impact of Metagenomic Analysis on the Discovery of Novel Endolysins

Applied Microbiology and Biotechnology
Metagenomics has revolutionized enzyme discovery by enabling the study of genetic material directly from environmental samples, bypassing the need for microbial cultivation.
Nikolaos E. Labrou, Panagiota D Pantiora, Georgios E Premetis   +2 more
exaly   +2 more sources

Clinical implementation of endolysins targeting gram-positive bacteria points toward a combination strategy with standard-of-care antibiotics: a selective review [PDF]

European Journal of Medical Research
Endolysins, which are peptidoglycan hydrolases derived from bacteriophages, are expected to innovate antimicrobial treatment. More specifically, several endolysins that target gram-positive bacteria are currently being evaluated in clinical trials ...
Niels Vander Elst
doaj   +2 more sources

Phage and endolysin-based inhibition of Klebsiella pneumoniae: from mechanisms to combination therapies [PDF]

Frontiers in Cellular and Infection Microbiology
Klebsiella pneumoniae (K. pneumoniae) is a critical ESKAPE pathogen with rapidly escalating resistance to last−line antibiotics, for which phages and their derived endolysins have emerged as promising alternatives. Phages specifically recognize bacterial
Yaojia Xia, Yaojia Xia, Yaojia Xia, Zhu Chen, Jieting Pan, Jieting Pan, Jieting Pan, Xibang Liu, Lijian Ding, Lijian Ding, Lijian Ding, Liming Jiang, Liming Jiang, Liming Jiang   +13 more
doaj   +2 more sources