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Phage-Encoded Endolysins [PDF]
Antibiotics, 2021 Due to the global emergence of antibiotic resistance, there has been an increase in research surrounding endolysins as an alternative therapeutic. Endolysins are phage-encoded enzymes, utilized by mature phage virions to hydrolyze the cell wall from ...
Fatma Abdelrahman +11 more
doaj +8 more sources
Endolysins of bacteriophages [PDF]
Журнал микробиологии, эпидемиологии и иммунобиологии, 2023 Bacteriophage endolysins are a biologically active substances that play a specific role in the release of phage progeny by degrading the peptidoglycan of the host bacterium.
Irina A. Barkova +2 more
doaj +3 more sources
Endolysins and Membrane-Active Peptides: Innovative Engineering Strategies Against Gram-Negative Bacteria [PDF]
Frontiers in MicrobiologyEndolysins, bacteriophage-encoded peptidoglycan hydrolases, offer promising potential in antibacterial therapy, including treatments targeting gram-negative bacteria.
Monika Wojciechowska
exaly +4 more sources
Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria
Journal of Biomedical Science, 2023 Gram-positive (G+) bacterial infection is a great burden to both healthcare and community medical resources. As a result of the increasing prevalence of multidrug-resistant G+ bacteria such as methicillin-resistant Staphylococcus aureus (MRSA), novel ...
He Liu +5 more
doaj +2 more sources
Synthetic biology of modular endolysins [PDF]
Biotechnology Advances, 2018 Endolysins and their derivatives have emerged in recent years as a novel class of antibacterials, which have now entered the clinical phases. Their rapid mode-of-action and proteinaceous nature differentiates them from any other class of antibiotics. A key feature of endolysins is their modularity and the opportunities that emerge thereof to customize ...
Gerstmans, Hans +2 more
openaire +4 more sources
Endolysins as Antimicrobials [PDF]
, 2012 Peptidoglycan (PG) is the major structural component of the bacterial cell wall. Bacteria have autolytic PG hydrolases that allow the cell to grow and divide. A well-studied group of PG hydrolase enzymes are the bacteriophage endolysins. Endolysins are PG-degrading proteins that allow the phage to escape from the bacterial cell during the phage lytic ...
Nelson, Daniel C. +6 more
openaire +5 more sources
Characterization of Three Different Endolysins Effective against Gram-Negative Bacteria
Viruses, 2023 Genes encoding endolysins were identified and cloned from three different Escherichia coli bacteriophages, 10-24(13), PBEC30, and PBEC56. Putative antimicrobial peptide (AMP)-like C-terminal alpha helix structures with amphipathic natures were predicted ...
Tae-Hwan Jeong +4 more
doaj +2 more sources
Bacteriophage-Derived Endolysins Applied as Potent Biocontrol Agents to Enhance Food Safety
Microorganisms, 2020 Endolysins, bacteriophage-encoded enzymes, have emerged as antibacterial agents that can be actively applied in food processing systems as food preservatives to control pathogens and ultimately enhance food safety.
Yoonjee Chang
doaj +2 more sources
Phage Endolysins: Advances in the World of Food Safety
Cells, 2023 As antimicrobial resistance continues to escalate, the exploration of alternative approaches to safeguard food safety becomes more crucial than ever. Phage endolysins are enzymes derived from phages that possess the ability to break down bacterial cell ...
Amina Nazir +3 more
doaj +2 more sources
Crystallographic Structure Determination of Bacteriophage Endolysins [PDF]
Current Issues in Molecular Biology, 2020 Bacteriophages produce endolysins that target and cleave the hosts peptidoglycan to release their progeny at the end of the infection cycle. These proteins can be used for the eradication of pathogenic bacteria, but also for their detection. Endolysins may contain a single catalytic domain or several domains, including a cell wall binding domain.
Sanz-Gaitero, Marta, van Raaij, Mark J.
openaire +4 more sources