Results 21 to 30 of about 4,149 (194)
Viruses, 2018 In response to increasing concern over antibiotic-resistant Staphylococcus aureus, the development of novel antimicrobials has been called for, with bacteriophage endolysins having received considerable attention as alternatives to antibiotics.
Bokyung Son, Minsuk Kong, Sangryeol Ryu
doaj +2 more sources
Acta Veterinaria ScandinavicaBacteriophage-encoded endolysins, peptidoglycan hydrolases breaking down the Gram-positive bacterial cell wall, represent a groundbreaking class of novel antimicrobials to revolutionize the veterinary medicine field.
Niels Vander Elst
doaj +2 more sources
The Advantages and Challenges of Using Endolysins in a Clinical Setting
Viruses, 2021 Antibiotic-resistant pathogens are increasingly more prevalent and problematic. Traditional antibiotics are no longer a viable option for dealing with these multidrug-resistant microbes and so new approaches are needed.
Ellen Murray +3 more
doaj +2 more sources
Molecular Docking of Endolysins for Studying Peptidoglycan Binding Mechanism
MoleculesEndolysins of bacteriophages, which degrade the bacterial cell wall peptidoglycan, are applicable in many industries to deal with biofilms and bacterial infections.
Arina G. Arakelian +2 more
doaj +2 more sources
Bacteriophage Endolysins as a Novel Class of Antibacterial Agents
Experimental Biology and Medicine, 2006 Endolysins are double-stranded DNA bacteriophage-encoded peptidoglycan hydrolases produced in phage-infected bacterial cells toward the end of the lytic cycle. They reach the peptidoglycan through membrane lesions formed by holins and cleave it, thus, inducing lysis of the bacterial cell and enabling progeny virions to be released.
Jan Jakub Borysowski +2 more
openaire +3 more sources
Journal of Pediatrics Review, 2018 Context: Spread of Methicillin-resistant Staphylococcus aureus (MRSA) can cause serious and sometimes fatal diseases especially in children. Outbreaks and increasing the prevalence of antibiotic-resistant MRSA at pediatric hospital calls for the ...
Golnar Rahimzadeh +2 more
doaj +1 more source
Immunogenicity of Endolysin PlyC
Antibiotics, 2022 Endolysins are bacteriolytic enzymes derived from bacteriophages. They represent an alternative to antibiotics, since they are not susceptible to conventional antimicrobial resistance mechanisms. Since non-human proteins are efficient inducers of specific immune responses, including the IgG response or the development of an allergic response mediated ...
Marek Adam Harhala +4 more
openaire +3 more sources
Polycationic Peptide Engineering of Phage Endolysins Expands Host Range and Enhances Antibacterial and Antibiofilm Activities Against Bacillus Species. [PDF]
Biotechnol BioengABSTRACT The exponential rise in antimicrobial resistance has highlighted the urgent need for the development of alternative antibacterial strategies, including phage‐derived and engineered protein agents such as endolysins and artilysins. In this study, we report the rational design, expression, and functional characterization of novel artilysins ...
Ansari F, Tarushi, Nagar V.
europepmc +2 more sources
Current Status of Endolysin-Based Treatments against Gram-Negative Bacteria
Antibiotics, 2021 The prevalence of multidrug-resistant Gram-negative bacteria is a public health concern. Bacteriophages and bacteriophage-derived lytic enzymes have been studied in response to the emergence of multidrug-resistant bacteria.
Marco Túlio Pardini Gontijo +2 more
doaj +1 more source
Frontiers in Microbiology, 2021 As the incidence of antibiotic-resistant bacteria has become increased, phage endolysins are believed as one of the promising alternatives to antibiotics.
Bokyung Son +7 more
doaj +1 more source