Results 31 to 40 of about 4,149 (194)
Phage endolysins are adapted to specific hosts and are evolutionarily dynamic.
PLoS Biology, 2022 Endolysins are produced by (bacterio)phages to rapidly degrade the bacterial cell wall and release new viral particles. Despite sharing a common function, endolysins present in phages that infect a specific bacterial species can be highly diverse and ...
Frank Oechslin +4 more
doaj +1 more source
Endolysin, a Promising Solution against Antimicrobial Resistance
Antibiotics, 2021 Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the effective prevention and control of ever-increasing infectious diseases.
Mujeeb ur Rahman +9 more
doaj +1 more source
Viruses, 2021 Bacteriophage-encoded endolysins have been identified as antibacterial candidates. However, the development of endolysins as mainstream antibacterial agents first requires a comprehensive biochemical understanding. This study defines the atomic structure
Michael J. Love +5 more
doaj +1 more source
Bacteriophage Endolysins as Novel Antimicrobials [PDF]
Future Microbiology, 2012 Endolysins are enzymes used by bacteriophages at the end of their replication cycle to degrade the peptidoglycan of the bacterial host from within, resulting in cell lysis and release of progeny virions. Due to the absence of an outer membrane in the Gram-positive bacterial cell wall, endolysins can access the peptidoglycan and destroy these organisms ...
Schmelcher M, Donovan DM, Loessner MJ
openaire +3 more sources
Bacteriophage Endolysins and their Applications
Science Progress, 2016 Endolysins (lysins) are bacteriophage-encoded enzymes that have evolved to degrade specific bonds within the bacterial cell wall. These enzymes represent a novel class of antibacterial agents against infectious pathogens, especially in light of multidrug-resistant bacteria, which have made antibiotic therapy increasingly redundant.
Jude, Ajuebor +5 more
openaire +2 more sources
Lytic characterization and application of listerial endolysins PlyP40 and PlyPSA in queso fresco
JDS Communications, 2021 Queso fresco (QF) is a fresh Hispanic-style cheese that is commonly associated with the human foodborne pathogen Listeria monocytogenes and outbreaks of listeriosis in the United States.
Maxwell J. Holle, Michael J. Miller
doaj +1 more source
Characterization of modular bacteriophage endolysins from Myoviridae phages OBP, 201φ2-1 and PVP-SE1. [PDF]
PLoS ONE, 2012 Peptidoglycan lytic enzymes (endolysins) induce bacterial host cell lysis in the late phase of the lytic bacteriophage replication cycle. Endolysins OBPgp279 (from Pseudomonas fluorescens phage OBP), PVP-SE1gp146 (Salmonella enterica serovar Enteritidis ...
Maarten Walmagh +4 more
doaj +1 more source
Physicochemical and Proteolytic Barriers Limiting Activity of Cpl-1 and Pal Endolysins in Human Circulation. [PDF]
Curr Issues Mol BiolThe growing prevalence of antibiotic-resistant bacterial infections poses a serious burden on healthcare systems worldwide. Endolysins are promising candidates for a new type of antibiotic due to their strong bacteriolytic activity.
Harhala MA +5 more
europepmc +2 more sources
VirusesBacteriophage-derived endolysins are being developed as an alternative to antimicrobials. The development of endolysins against Gram-negative bacteria requires the discovery of effective endolysins against the target species and the capability to ...
Masato Kogawa +7 more
doaj +1 more source
Recent Advances in Endolysin Engineering. [PDF]
Antibiotics (Basel)Antimicrobial resistance threatens a new “dark age” in medical practice. Chronic antibiotic overuse has driven the rise in antimicrobial resistance and promoted the emergence of multidrug-resistant organisms. To address this problem, researchers have developed new approaches.
Aitken M +3 more
europepmc +4 more sources