Results 121 to 130 of about 494 (158)

Biological Variation of Holotranscobalamin and Cobalamin in Healthy Individuals

Scandinavian Journal of Clinical and Laboratory Investigation, 2017
Data on biological variation for cobalamin and holotranscobalamin (holoTC) are limited. The aim of this study was to determine within-subject (CVI) and between-subject (CVG) biological variations for these analytes in a healthy population. We collected blood samples from 15 healthy volunteers (12 women and three men, 22-66 years) on the same weekday ...
Helle Borgstrøm Hager, Morten Lindberg, Mette Brokner   +2 more
exaly   +3 more sources

Holotranscobalamin as a Predictor of Vitamin B12 Status

Clinical Chemistry and Laboratory Medicine, 2003
We report on the performance of a new test, holotranscobalamin, as compared to well established markers of vitamin B12 deficiency (plasma cobalamins, methylmalonic acid, and homocysteine). Holotranscobalamin was analyzed in 143 samples by a competitive radiobinding assay (Axis-Shield). Employing a cut-off value of 50 pmol/l, holotranscobalamin showed a
Anne-Mette, Hvas, Ebba, Nexo
openaire   +4 more sources

Reference Intervals and Stability of Haptocorrin and Holotranscobalamin in Danish Children and Elderly

Clinica Chimica Acta, 2023
Haptocorrin (HC) and holotranscobalamin (holoTC) carry vitamin B12 (B12) in the circulation and can be useful biomarkers for evaluating B12 status. The concentration of both proteins depends on age, but data on reference intervals for children and the elderly are sparse.
Knudsen, Cindy S., Parkner, Tina, Hoffmann-Lücke, Elke; id_orcid 0000-0002-2437-0140, Abildgaard, Anders; id_orcid 0000-0001-7272-0953, Greibe, Eva; id_orcid 0000-0002-0417-1195   +4 more
exaly   +3 more sources

Failure of the Holotranscobalamin Assay in Vitamin B12-Deficient Patients [PDF]

Journal of Laboratory Medicine, 2018
AbstractBackgroundIt has been demonstrated that vitamin B12 determinations fail, especially in patients with pernicious anemia with high titers of intrinsic factor antibody. Consistent with this finding, we observed a case of falsely normal holotranscobalamin (HoloTC) results in a patient with pernicious anemia and severe vitamin B12 deficiency.
Urs Nydegger, Renz Harald, Lorenz Risch
exaly   +2 more sources

Holotranscobalamins in B12 and non B12 requiring prokaryotes and eukaryotes

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 1996
Transcobalamins, vitamin B12 binding proteins, deliver B12 to cell surface receptors which then permit B12 to cross cell membranes for metabolic use. There is little documentation concerning B12 binding proteins in bacteria and protists. We found that prokaryotes and eukaryotes requiring B12, as well as those protists synthesizing B12, also produce ...
H, Baker, B, de Angelis, M, Khalil, O, Frank, E R, Baker   +4 more
openaire   +2 more sources

Holotranscobalamin Levels in Children with Helicobacter Pylori Infection

Helicobacter, 2015
AbstractBackgroundThe purpose of this study was to evaluate the association between vitamin B12 levels and Helicobacter Pylori infection and to examine the clinical usefulness of holotranscobalamin (holoTC) measurement in children.Materials and MethodsThirty patients between 6 and 15 years of age, who were diagnosed as H.
Oguz, Afyoncu, Orhan, Gursel, Avni, Atay, Emin, Kurekci, Necati, Balamtekin, Adnan, Hasimi, Mehmet A, Ozguven, Okan, Ozcan   +7 more
openaire   +2 more sources

Performance Characteristics of the ARCHITECT Active-B12 (Holotranscobalamin) Assay

Clinical Laboratory, 2015
Vitamin B12 (cobalamin) is a necessary cofactor in methionine and succinyl-CoA metabolism. Studies estimate the deficiency prevalence as high as 30% in the elderly population. Ten to thirty percent of circulating cobalamin is bound to transcobalamin (holotranscobalamin, holoTC) which can readily enter cells and is therefore considered the bioactive ...
Stephen D, Merrigan, William E, Owen, Joely A, Straseski   +2 more
openaire   +2 more sources

Chemotherapy-induced suppression of serum holotranscobalamin

Journal of Clinical Oncology, 2009
e20639 Purpose: Chemotherapy-induced damage to the stomach and small intestine may inhibit the absorption of vitamin B12. To assess the risk of chemotherapy causing acute vitamin B12 deficiency, we primarily measured the active form of vitamin B12, holotranscobalamin, but also total serum B12, methylmalonic acid, and total homocysteine.
G. Tisman, S. J. Kutik, Y. A. Khan
openaire   +1 more source

The relationship of leukocyte anisocytosis to holotranscobalamin, a marker of cobalamin deficiency

International Journal of Laboratory Hematology, 2011
SummaryIntroduction:  After measurement of the mean volumes of leukocyte subpopulations as well as the distribution widths (DW) of these volumes has become available, we investigated whether such morphometric leukocyte parameters are associated with a commonly used marker of cobalamin deficiency, i.e., holotranscobalamin (HoloTC).
C, Risch, P, Medina, U E, Nydegger, Z, Bahador, T, Brinkmann, P, Von Landenberg, M, Risch, L, Risch   +7 more
openaire   +2 more sources

CLINICAL USEFULNESS OF HOLOTRANSCOBALAMIN MEASUREMENT

Clinical chemistry and laboratory medicine, 2008
The aim of this study was to assess clinical usefulness of holotranscobalamin measurement.
Mandić, Sanja, Horvat, Vesna, Mandić, Dario, Majetić-Cetina, Neda   +3 more
openaire   +2 more sources