Results 101 to 110 of about 1,234 (191)

Non-hematological manifestations of vitamin B12 deficiency and excess: clinical spectrum and management

The Egyptian Journal of Internal Medicine
Background Vitamin B12 deficiency is traditionally recognized through megaloblastic anemia, yet accumulating evidence shows a broad spectrum of non‑hematological manifestations and clinically relevant associations with elevated serum B12.
Amin R. Soliman, Shaimaa Shaheen, Rana Walid, Ahmed Elamragy, Ayman Hany, Eslam Abu-Naeima, Lobna Sedky, Doaa M. Mahgoub, Mona Hegazy, Amira Khalifa, Nadia M. Tawfik   +10 more
doaj   +1 more source

Seminal but not serum levels of holotranscobalamin are altered in morbid obesity and correlate with semen quality: a pilot single centre study [PDF]

, 2019
Vitamin B12 (cobalamin) is an essential cofactor in the one-carbon metabolism. One-carbon metabolism is a set of complex biochemical reactions, through which methyl groups are utilised or generated, and thus plays a vital role to many cellular functions ...
Michaela Luconi, Saravanan, P, Saravanan, Ponnusamy, Luconi, Michaela, Marcello Lucchese, Facchiano, Enrico, Lucchese, Marcello, Samavat, J, Mario Maggi, Cantini, Giulia, Cantini, G, Samavat, Jinous, Giulia Cantini, Ognibene, A, Lorubbio, Maria, Antonysunil Adaikalakoteswari, Adaikalakoteswari, A, Ognibene, Agostino, Jinous Samavat, Adaikalakoteswari, Antonysunil, Luconi, M, Enrico Facchiano, Facchiano, E, Lucchese, M, Maggi, Mario, Agostino Ognibene, Maria Lorubbio, Degl’Innocenti, S, Degl’Innocenti, Selene, Selene Degl’Innocenti, Maggi, M, Lorubbio, M, Degl'Innocenti, S, Ponnusamy Saravanan   +33 more
core   +1 more source

Comparability and stability of holotranscobalamin levels in capillary and venous blood

Aim: Self-collected capillary blood offers several advantages over phlebotomy samples. However, evidence that venous and capillary serum are comparable for many routine analytes is limited. In this study, we aimed
Macarena Staudenmaier, Timothy Woolley, Emma Rutter   +2 more
core   +1 more source

Low holotranscobalamin and cobalamins predict incident fractures in elderly men: the MrOS Sweden

, 2014
In a population-based study on cobalamin status and incident fractures in elderly men (n = 790) with an average follow-up of 5.9 years, we found that low levels of metabolically active and total cobalamins predict incident fractures, independently of ...
Lorentzon, M., Nilsson-Ehle, H., Johansson, H., Ohlsson, Claes,, Lewerin, Catharina,, Sundh, V., Karlsson, Magnus, Kanis, J A, Lerner, Ulf H,, Lewerin, C., Jacobsson, Stefan,, Karlsson, M K, Ljunggren, O, Cummings, S. R., Nilsson-Ehle, Herman,, Cummings, S R, Ljunggren, Östen,, Lorentzon, Mattias,, Jacobsson, S., Johansson, Helena,, Mellström, Dan,, Lerner, Ulf H.,, Karlsson, Magnus,, Lerner, U. H., Sundh, Valter,, Mellstrom, D., Ohlsson, C., Ljunggren, O., Kanis, J. A., Karlsson, M. K., Lund University.   +30 more
core   +1 more source

Single-blinded, stratified, dose ranging trial to assess pharmacokinetics and identify optimal dose of vitamin B12 in pregnancy in Tanzania [version 2; peer review: 1 approved, 3 approved with reservations]

Gates Open Research
Background Vitamin B12 is an essential cofactor for two enzymes that have critical functions in pregnancy, both for maternal health and fetal development.
Omar Lweno, Matthew D. Barberio, Victoria S. Reynolds, Sabina Mugusi, Kevin C. Klatt, Zohra Lukmanji, Mathangi Gopalakrishnan, Homa K. Ahmadzia, Fadhlun M. Alwy Al-beity, Leigh A. Martin, Amrita Arcot, Brooke Langevin, Ali Rahnavard, Emily R. Smith, Kelly Gallagher, Honorati Masanja, Alison D. Gernand   +16 more
doaj   +1 more source

DIAGNOSTIC VALUE OF HOLOTRANSCOBALAMIN IN ASSESSMENT OF VITAMIN B12 DEFICIENCY

Clinical chemistry and laboratory medicine, 2017
Background Different neurological manifestations could be a consequence of vitamin B12 deficit, even when vitamin B12 concentrations are within reference intervals. In theory, measurement of amount of vitamin B12 available for the cells, known as holotranscobalamin, could be a more sensitive indicator of B12 deficiency in such cases.
Mandić, Dario, Mandić, Sanja, Horvat, Vesna, Sarić, Ivana, Šerić, Vatroslav   +4 more
openaire   +3 more sources

Measuring holotranscobalamin II, an early indicator of negative vitamin B-12 balance, by radioimmunoassay in patients with ischemic cerebrovascular disease

, 2008
Circulating homocysteine is a risk factor of cardiovascular and cerebrovascular events. Hyperhomocysteinemia may be an early indicator for vitamin B-12 disorders because cobalamin is a cofactor in the remethylation process of homocysteine.
KEKİLLİ, ERSOY, KUKU, İRFAN, Serefhanoglu, Songul, Aydogdu, Ismet, Ilhan, Atilla   +4 more
core   +1 more source

Low holotranscobalamin and cobalamins predict incident fractures in elderly men: the MrOS Sweden Study

, 2014
In a population-based study on cobalamin status and incident fractures in elderly men (n = 790) with an average follow-up of 5.9 years, we found that low levels of metabolically active and total cobalamins predict incident fractures, independently of ...
Cummings, S R, Lorentzon, Mattias,, Ohlsson, Claes,, Lewerin, Catharina,, Ljunggren, Östen, Johansson, Helena,, Mellström, Dan,, Kanis, J A, Lerner, Ulf H,, Sundh, Valter,, Jacobsson, Stefan,, Karlsson, M K, Nilsson-Ehle, Herman,   +12 more
core  

Clinical case of funicular myelosis in combination with a concomitant genetic predisposition to folate cycle disorder

Medičnì Perspektivi
Funicular myelosis (sub­acute combined degeneration) is a disease characterized by the development of degeneration of the posterior and lateral cords of the spinal cord.
O.D. Shulga , E.A. Popko, A.S. Chabanova , O.G. Kotsiuba , Q. Hussain   +4 more
doaj   +1 more source

Effect of isotretinoin treatment on plasma holotranscobalamin, vitamin B12, folic acid, and homocysteine levels: non-controlled study

, 2011
Isotretinoin (Iso) has been used for the treatment of acne. Some previous studies reported elevated homocysteine (Hcy) levels after treatment with Iso.
Emre Tutal, Tutal, Emre, Karadag, Ayse Serap, Derun Taner Ertugrul, Ertugrul, Derun Taner, Ayse Serap Karadag, Akin, Kadir Okhan, Kadir Okhan Akin   +7 more
core   +1 more source