Results 101 to 110 of about 494 (158)

Vitamin B12 deficiency: epidemiological trends and risk factors

Frontiers in Nutrition
Vitamin B12 (cobalamin) can only be obtained from animal food sources and is important for several functions, including DNA synthesis, haematopoiesis and myelination. It is one of the most common micronutrient deficiencies worldwide.
Gurudayal S. Toteja, Nishant Toteja
doaj   +1 more source

Early biomarker response and patient preferences to oral and intramuscular vitamin B12 substitution in primary care: a randomised parallel-group trial

Swiss Medical Weekly, 2017
BACKGROUND Vitamin B12 (VB12) deficiency can be treated with oral high-dose substitution or intramuscular (IM) injection of VB12. Whenever alternative routes of administration exist, patient preferences should be considered when choosing the ...
Corina Metaxas, Deborah Mathis, Cyrill Jeger, Kurt E. Hersberger, Isabelle Arnet, Philipp Walter   +5 more
doaj   +1 more source

Non-hematological manifestations of vitamin B12 deficiency and excess: clinical spectrum and management

The Egyptian Journal of Internal Medicine
Background Vitamin B12 deficiency is traditionally recognized through megaloblastic anemia, yet accumulating evidence shows a broad spectrum of non‑hematological manifestations and clinically relevant associations with elevated serum B12.
Amin R. Soliman, Shaimaa Shaheen, Rana Walid, Ahmed Elamragy, Ayman Hany, Eslam Abu-Naeima, Lobna Sedky, Doaa M. Mahgoub, Mona Hegazy, Amira Khalifa, Nadia M. Tawfik   +10 more
doaj   +1 more source

False low holotranscobalamin levels in a patient with a novel TCN2 mutation [PDF]

, 2019
Background: Measurement of holotranscobalamin (holoTC) is increasingly used as a screening test for cobalamin (Cbl) deficiency. A level well below the reference interval strongly supports a deficient state.
Rufener, Janine, Nexo, Ebba, Keller, Peter, Fedosov, Sergey N., Nissen, Peter H., Schild, Christof   +5 more
core  

Are vitamin B-12 measurements adequate for evaluating its deficiency in individuals?

BACKGROUND AND OBJECTIVES: Measurement of vitamin B-12 deficiency using different methods may cause diagnostic difficulties. In order to rapidly and safely diagnose vitamin B-12 deficiency, it is important to determine the reference ranges of serum B-12 ...
Özdemir, Sedat, Demirtaş, Selda
core   +1 more source

Development and Temporal Validation of Explainable Machine Learning Models for Predicting Vitamin B12 Deficiency Using Routine Laboratory Analytes

Diagnostics
Background/Objectives: Vitamin B12 deficiency is a prevalent yet frequently underdiagnosed condition, largely due to the limited diagnostic accuracy of serum total B12 and the restricted availability of confirmatory biomarkers such as holotranscobalamin ...
Ferhat Demirci, Oktay Yıldırım, Aylin Demirci, Pınar Akan   +3 more
doaj   +1 more source

DIAGNOSTIC VALUE OF HOLOTRANSCOBALAMIN IN ASSESSMENT OF VITAMIN B12 DEFICIENCY

Clinical chemistry and laboratory medicine, 2017
Background Different neurological manifestations could be a consequence of vitamin B12 deficit, even when vitamin B12 concentrations are within reference intervals. In theory, measurement of amount of vitamin B12 available for the cells, known as holotranscobalamin, could be a more sensitive indicator of B12 deficiency in such cases.
Mandić, Dario, Mandić, Sanja, Horvat, Vesna, Sarić, Ivana, Šerić, Vatroslav   +4 more
openaire   +3 more sources

Maternal supplementation of vitamin B12 in predominantly vegetarian pregnant women improves their vitamin B12 status and the neurodevelopment of their infants: the MATCOBIND multicentric double-blind randomised control trial

BMJ Paediatrics Open
Background Vitamin B12 deficiency is common in populations with limited animal-source foods and has been linked to delayed infant neurodevelopment and adverse pregnancy outcomes.
Michelle Heys, Mario Cortina-Borja, Monica Lakhanpaul, Colin Michie, Jitender Nagpal, Swapnil Rawat, Deepti Nagrath, Atul Singhal, Jageshwor Gautam, Rajendra Pant, Anita Shah, Laura Nixon, Shailendra Bir Karmacharya, Manu Mathur, Vijay Kumar Mishra, Snighda Rai   +15 more
doaj   +1 more source

Vitamin B12 Status Upon Short-Term Intervention with a Vegan Diet-A Randomized Controlled Trial in Healthy Participants

, 2019
Vegans are at an increased risk for certain micronutrient deficiencies, foremost of vitamin B; 12; . Little is known about the short-term effects of dietary change to plant-based nutrition on vitamin B; 12; metabolism.
Andrea Maul-Pavicic, Samstag, Yvonne, Müller, Alexander, Michael Schmiech, Sidney Behringer, Thomas Simmet, Ann-Kathrin Lederer, Gründemann, Carsten, Alexander Müller, Müller, Alexander Markus, Yvonne Samstag, Spiekerkoetter, Ute, Ute Spiekerkoetter, Maul-Pavicic, Andrea, Zimmermann-Klemd, Amy Marisa, Huber, Roman, Amy Marisa Zimmermann-Klemd, Hettich, Manuel, Carmen Steinborn, Steinborn, Carmen, Luciana Hannibal, Spiekerkötter, Ute, Manuel Hettich, Carsten Gründemann, Behringer, Sidney, Simmet, Thomas, Lederer, Ann-Kathrin, Hannibal, Luciana, Roman Huber, Schmiech, Michael   +29 more
core   +1 more source

Single-blinded, stratified, dose ranging trial to assess pharmacokinetics and identify optimal dose of vitamin B12 in pregnancy in Tanzania [version 2; peer review: 1 approved, 3 approved with reservations]

Gates Open Research
Background Vitamin B12 is an essential cofactor for two enzymes that have critical functions in pregnancy, both for maternal health and fetal development.
Omar Lweno, Matthew D. Barberio, Victoria S. Reynolds, Sabina Mugusi, Kevin C. Klatt, Zohra Lukmanji, Mathangi Gopalakrishnan, Homa K. Ahmadzia, Fadhlun M. Alwy Al-beity, Leigh A. Martin, Amrita Arcot, Brooke Langevin, Ali Rahnavard, Emily R. Smith, Kelly Gallagher, Honorati Masanja, Alison D. Gernand   +16 more
doaj   +1 more source