Results 81 to 90 of about 1,234 (191)

Serum vitamin B12, distal symmetrical polyneuropathy and anaemia in type 2 diabetes: the Fremantle Diabetes Study Phase 2

Internal Medicine Journal, Volume 54, Issue 4, Page 575-581, April 2024.
Abstract Background There are limited data relating to the effects of metformin‐associated vitamin B12 deficiency on the risk of distal symmetrical polyneuropathy (DSPN) and megaloblastic anaemia in well‐characterised community‐based cohorts. Aims To assess inter‐relationships between metformin therapy, vitamin B12 deficiency assessed using serum ...
Timothy M. E. Davis, Stephen A. P. Chubb, Kirsten E. Peters, Wendy A. Davis   +3 more
wiley   +1 more source

Scientific Opinion on Dietary Reference Values for cobalamin (vitamin B12)

EFSA Journal, 2015
Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for cobalamin (vitamin B12).
EFSA Panel on Dietetic Products, Nutrition, and Allergies (NDA)
doaj   +1 more source

Influence of duration and dose of metformin on cobalamin deficiency in type 2 diabetes patients using metformin [PDF]

, 2015
Metformin use is associated with cobalamin (vitamin B12) deficiency. However, the influence of both duration and dose of metformin is unclear. Studies using holotranscobalamin, a marker for cellular cobalamin deficiency, are scarce.
Hart, Huberta E., Kooijman-Buiting, Antoinette M J, Kooijman-Buiting, Antoinette M.J., Rutten, Guy E.H.M., Kuijs, Ron, Beulens, Joline W J, Beulens, Joline W.J., Rutten, Guy E H M   +7 more
core   +1 more source

Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice

Journal of the Science of Food and Agriculture, Volume 104, Issue 2, Page 875-882, 30 January 2024.
Abstract BACKGROUND Vitamin B12 is an essential nutrient that is involved in numerous physiological processes, and its deficiency can lead to various complications, including neurological and haematological disorders. Some studies have suggested that vitamin B12 may have anti‐inflammatory effects, but the mechanisms underlying this relationship are not
Inés Domínguez‐López, Marta Kovatcheva, Rosa Casas, Estefanía Toledo, Montserrat Fitó, Emilio Ros, Ramon Estruch, Manuel Serrano, Rosa M. Lamuela‐Raventós   +8 more
wiley   +1 more source

Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin. [PDF]

, 2007
peer-reviewedBackground: Impaired vitamin B12 function and decreased vitamin B12 status have been associated with neurological and cognitive impairment.
MOLLOY, ANNE MARIE, SCOTT, JOHN MARTIN
core   +2 more sources

Vitamin B12 status and the risk of developing sepsis in patients with bacterial infection: a prospective observational cohort study

BMC Medicine
Background Data have shown that vitamin B12 has immunomodulatory effects via different pathways, which could influence the pathophysiology of sepsis. The objective of this study was to investigate whether vitamin B12 levels, assessed by the measurement ...
Andreas Pregernig, Ulrike Held, Martin Schläpfer, Beatrice Beck-Schimmer   +3 more
doaj   +1 more source

The effect of recombinant human intrinsic factor on the uptake of vitamin B12 in patients with evident vitamin B12 deficiency

Haematologica, 2006
We report on the use of recombinant human intrinsic factor (rhIF) in a new vitamin B12 absorption test. Holotranscobalamin (holoTC) was measured before and 24 hours after intake of three 9-mg doses of vitamin B12 (B12) and again 24 hours after intake of ...
AM Hvas, H Buhl, NB Laursen, B Hesse, L Berglund, E Nexo   +5 more
doaj  

False low holotranscobalamin levels in a patient with a novel TCN2 mutation [PDF]

, 2019
Background: Measurement of holotranscobalamin (holoTC) is increasingly used as a screening test for cobalamin (Cbl) deficiency. A level well below the reference interval strongly supports a deficient state.
Rufener, Janine, Nexo, Ebba, Keller, Peter, Fedosov, Sergey N., Nissen, Peter H., Schild, Christof   +5 more
core  

La polimedicación en mayores institucionalizados: su efecto sobre los niveles de vitamina B12, folato y homocisteína Polymedication in institutionalized elderly and its effect on vitamin B12, folate, and homocysteine levels

Nutrición Hospitalaria, 2012
Objetivo: Determinar qué tipo de medicamentos consume una población de ancianos institucionalizados en la Comunidad de Madrid y valorar la influencia de estos fármacos sobre las concentraciones de vitamina B12 (B12 y holotranscobalamina), folato sérico ...
U. Albers, G. Palacios, R. Pedrero-Chamizo, A. Meléndez, K. Pietrzik, M. González-Gross   +5 more
doaj  

Effects of Immune Complexes on Holotranscobalamine Assay of Vitamin B12 Deficiency in Myeloproliferative Disorders

International Journal of Hematology and Oncology, 2019
In myeloproliferative disorders (MPDs), vitamin B-12 levels are measured falsely elevated with conventional methods due to increased carrier protein synthesis. HoloTranscobalamine (HoloTC) assay is a first-choice method for detecting true vitamin B-12 deficiency in MPDs. Our aim was to determine effects of immune complexes on HoloTC assay.
Gunduz, Mehmet, Dilaveroglu, Nilgun, Aydemir, Birsen, Cinemre, Fatma Behice Serinkan, Cekdemir, Demet, Cinemre, Hakan, Cekdemir, Yasin Ertug   +6 more
openaire   +3 more sources