Results 71 to 80 of about 494 (158)

A systematic review and meta‐analysis of functional vitamin B12 status among adult vegans

Nutrition Bulletin, Volume 49, Issue 4, Page 463-479, December 2024.
Abstract The dietary intake of vitamin B12 among unsupplemented vegans is notably lower compared to both vegetarians and omnivores. Prolonged low intakes of vitamin B12, such as seen in those adhering to a vegan diet, lead to physiological deficiency of vitamin B12 and an elevated risk of B12‐related morbidity.
Ali Niklewicz, Luciana Hannibal, Martin Warren, Kourosh R. Ahmadi   +3 more
wiley   +1 more source

Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility [PDF]

The American Journal of Clinical Nutrition, 2011
Approximately one-quarter of circulating cobalamin (vitamin B-12) binds to transcobalamin (holoTC) and is thereby available for the cells of the body. For this reason, holoTC is also referred to as active vitamin B-12. HoloTC was suggested as an optimal marker of early vitamin B-12 deficiency >20 y ago.
Nexø, Ebba; id_orcid 0000-0001-9406-9081, Hoffmann-Lücke, Elke; id_orcid 0000-0002-2437-0140   +1 more
openaire   +3 more sources

Correlation coefficients among plasma methyl nutrient and metabolites, folate and vitamin B12¹.

, 2013
1Spearman’s correlation coefficients, with significant correlations shown in bold ...
Sheila M. Innis (310920), Roger A. Dyer (310917), Brian T. F. Wu (310916), D. Janette King (310918), Kelly J. Richardson (310919)   +4 more
core   +1 more source

Multicentre evaluation of the Roche Elecsys® Active B12 (holotranscobalamin) electro-chemiluminescence immunoassay [PDF]

, 2019
Background: Vitamin B12 deficiency is a common disorder. In circulation, vitamin B12 is bound to transcobalamin (holotranscobalamin), which is considered the active form of cobalamin. The objective of this study was to evaluate the analytical performance
Sun, Y. (Yuli), Heil, S.G. (Sandra), Rijke, Y.B. (Yolanda) de, Findeisen, P. (Peter), Luebcke, S. (Silke), Bodenburg, P. (Petra), Heil, Sandra, Bodenburg, P, Findeisen, P, de Rijke, Yolanda, Luebcke, S, Sun, YL   +11 more
core   +1 more source

Microangiopathic thrombocytopenia caused by vitamin B12 deficiency responding to plasma exchange

British Journal of Haematology, Volume 205, Issue 4, Page 1546-1550, October 2024.
Summary A young adult African American female presented with normocytic microangiopathic haemolytic anaemia, elevated lactate dehydrogenase and thrombocytopenia. The patient responded to therapeutic plasma exchanges (TPE) for presumed thrombotic microangiopathy caused by thrombotic thrombocytopenic purpura (TTP).
Denis M. Dwyre, Jyotsna Reddy, Leonor P. Fernando, Jacob M. Donnelly, Joshua W. Miller, Ralph Green   +5 more
wiley   +1 more source

Determination of serum holotranscobalamin concentrations with the AxSYM active B-12 assay: cut-off point evaluation in the clinical laboratory [PDF]

, 2009
Background: A reliable early marker is required for diagnosis of cobalamin deficiency. We calculated an appropriate holotranscobalamin (HoloTC) cut-off point for identifying cobalamin deficiency using an immunoenzymatic assay.
Galli C., Lonati, Silvia, Bamonti, Fabrizia, R. De Giuseppe, Moscato G. A., C. Novembrino, Lonati S., DE GIUSEPPE R, GALLI C, NOVI C, Novembrino C., Uva V., F. Bamonti, Galli, Claudio, R. Maiavacca, Novembrino, Cristina, MOSCATO GA, MAIAVACCA R., NOVEMBRINO C, Bamonti F., V. Uva, C. Novi, Gregori D., UVA V, LONATI S, C. Galli, Giuseppe, Rachele De, Novi, Claudia, Novi C., De Giuseppe R., G. A. Moscato, GREGORI, DARIO, D. Gregori, Moscato, Giovanna Antonella, Maiavacca, Rita, BAMONTI F, Uva, Valentina, S. Lonati   +37 more
core   +1 more source

Intranasal vitamin B12 administration in elderly patients: A randomized controlled comparison of two dosage regimens

British Journal of Clinical Pharmacology, Volume 90, Issue 8, Page 1975-1983, August 2024.
Aim Vitamin B12 deficiency is common in the elderly population. Standard treatment via intramuscular injections, however, has several disadvantages. Safer and more convenient dosage forms such as intranasal are therefore being explored. This study compares the effects of two intranasal vitamin B12 dosage regimens in elderly vitamin B12‐deficient ...
Monique P. H. Tillemans, Thijs J. Giezen, Toine C. G. Egberts, Jan H. Hooijberg, Kees J. Kalisvaart   +4 more
wiley   +1 more source

Hampered Vitamin B12 Metabolism in Gaucher Disease?

Journal of Inborn Errors of Metabolism and Screening, 2017
Untreated vitamin B 12 deficiency manifests clinically with hematological abnormalities and combined degeneration of the spinal cord and polyneuropathy and biochemically with elevated homocysteine (Hcy) and methylmalonic acid (MMA).
Luciana Hannibal PhD, Marina Siebert PhD, Suélen Basgalupp MSc, Filippo Vario MD, PhD, Ute Spiekerkoetter MD, Henk J. Blom PhD   +5 more
doaj   +1 more source

Serum vitamin B12, distal symmetrical polyneuropathy and anaemia in type 2 diabetes: the Fremantle Diabetes Study Phase 2

Internal Medicine Journal, Volume 54, Issue 4, Page 575-581, April 2024.
Abstract Background There are limited data relating to the effects of metformin‐associated vitamin B12 deficiency on the risk of distal symmetrical polyneuropathy (DSPN) and megaloblastic anaemia in well‐characterised community‐based cohorts. Aims To assess inter‐relationships between metformin therapy, vitamin B12 deficiency assessed using serum ...
Timothy M. E. Davis, Stephen A. P. Chubb, Kirsten E. Peters, Wendy A. Davis   +3 more
wiley   +1 more source

Diagnosis of Vitamin B-12 Deficiency in Patients With Myeloproliferative Disorders

, 2015
Conclusions: Patients who had myeloproliferative disorders had a high prevalence of vitamin B-12 deficiency, despite high serum vitamin B-12 levels.
Aydemir, Birsen, Cinemre, Hakan, Demet Cekdemir, Yazar, Hayrullah, Behice F. Serinkan Cinemre, Tamer, Ali   +5 more
core   +1 more source