Results 71 to 80 of about 1,234 (191)

Holotranscobalamin – An Early Marker for Laboratory Diagnosis of Vitamin B12 Deficiency [PDF]

European Oncology & Haematology, 2009
Vitamin B 12 deficiency is widespread. Among the population groups at risk are older people, vegetarians, pregnant women and patients with renal or intestinal diseases. The neurological symptoms of vitamin B 12 deficiency are unspecific and can be ...
Rima Obeid, Wolfgang Herrmann
openaire   +1 more source

Emerging Noninvasive Biomolecular Checkpoints for Healthy Microbiomes

Advanced Gut &Microbiome Research, Volume 2025, Issue 1, 2025.
Dysbiosis commonly impacts otherwise healthy individuals over the age of 50 due to seemingly innocuous changes in diet, hydration, or physical activity. Noninvasive biomarkers are emerging as checkpoints for immune health, energy‐yielding metabolization, and oxidative stress during the aging process.
A. Dahl, M. J. Pugia, Jian Wu
wiley   +1 more source

Holotranscobalamin, a marker of vitamin B-12 status: analytical aspects and clinical utility [PDF]

The American Journal of Clinical Nutrition, 2011
Approximately one-quarter of circulating cobalamin (vitamin B-12) binds to transcobalamin (holoTC) and is thereby available for the cells of the body. For this reason, holoTC is also referred to as active vitamin B-12. HoloTC was suggested as an optimal marker of early vitamin B-12 deficiency >20 y ago.
Nexø, Ebba; id_orcid 0000-0001-9406-9081, Hoffmann-Lücke, Elke; id_orcid 0000-0002-2437-0140   +1 more
openaire   +3 more sources

The distribution of total vitamin b12 holotranscobalamin and the active vitamin b12 fraction in the first 5 weeks postpartum [PDF]

, 2017
Introduction Total vitamin B12 levels decrease significantly during pregnancy and recover to normal values within 8-week postpartum. Holotranscobalamin (holoTC) reflects the active part of vitamin B12 and has been shown to remain constant during ...
van der Woude, D.A.A., Vries, J de, E. M. van Wijk, Woude, D.A.A. van der, de Vries, J., D. A. A. van der Woude, WIjk, E.M. van, J. de Vries, van Wijk, E.M., J. M. A. Pijnenborg, Pijnenborg, J.M.A.   +10 more
core   +2 more sources

A systematic review and meta‐analysis of functional vitamin B12 status among adult vegans

Nutrition Bulletin, Volume 49, Issue 4, Page 463-479, December 2024.
Abstract The dietary intake of vitamin B12 among unsupplemented vegans is notably lower compared to both vegetarians and omnivores. Prolonged low intakes of vitamin B12, such as seen in those adhering to a vegan diet, lead to physiological deficiency of vitamin B12 and an elevated risk of B12‐related morbidity.
Ali Niklewicz, Luciana Hannibal, Martin Warren, Kourosh R. Ahmadi   +3 more
wiley   +1 more source

Microangiopathic thrombocytopenia caused by vitamin B12 deficiency responding to plasma exchange

British Journal of Haematology, Volume 205, Issue 4, Page 1546-1550, October 2024.
Summary A young adult African American female presented with normocytic microangiopathic haemolytic anaemia, elevated lactate dehydrogenase and thrombocytopenia. The patient responded to therapeutic plasma exchanges (TPE) for presumed thrombotic microangiopathy caused by thrombotic thrombocytopenic purpura (TTP).
Denis M. Dwyre, Jyotsna Reddy, Leonor P. Fernando, Jacob M. Donnelly, Joshua W. Miller, Ralph Green   +5 more
wiley   +1 more source

Holotranscobalamin is not influenced by decreased renal function in elderly men: the MrOS Sweden study

, 2013
Background Subclinical cobalamin deficiency is common in the elderly, but the sensitivity and specificity of serum total cobalamin for this diagnosis is poor. Serum holotranscobalamin (holoTC), a measure of biologically available cobalamin, is considered
Jacobsson, Stefan, Ohlsson, Claes, Mellstrom, Dan, Lund University., Lewerin, Catharina, Nilsson-Ehle, Herman, Karlsson, Magnus,   +6 more
core   +2 more sources

Hampered Vitamin B12 Metabolism in Gaucher Disease?

Journal of Inborn Errors of Metabolism and Screening, 2017
Untreated vitamin B 12 deficiency manifests clinically with hematological abnormalities and combined degeneration of the spinal cord and polyneuropathy and biochemically with elevated homocysteine (Hcy) and methylmalonic acid (MMA).
Luciana Hannibal PhD, Marina Siebert PhD, Suélen Basgalupp MSc, Filippo Vario MD, PhD, Ute Spiekerkoetter MD, Henk J. Blom PhD   +5 more
doaj   +1 more source

Intranasal vitamin B12 administration in elderly patients: A randomized controlled comparison of two dosage regimens

British Journal of Clinical Pharmacology, Volume 90, Issue 8, Page 1975-1983, August 2024.
Aim Vitamin B12 deficiency is common in the elderly population. Standard treatment via intramuscular injections, however, has several disadvantages. Safer and more convenient dosage forms such as intranasal are therefore being explored. This study compares the effects of two intranasal vitamin B12 dosage regimens in elderly vitamin B12‐deficient ...
Monique P. H. Tillemans, Thijs J. Giezen, Toine C. G. Egberts, Jan H. Hooijberg, Kees J. Kalisvaart   +4 more
wiley   +1 more source

Screening for metabolic vitamin B-12 deficiency by holotranscobalamin in patients suspected of vitamin B-12 deficiency: a multicentre study [PDF]

, 2012
Background: Vitamin B-12 deficiency occurs frequently, especially among the elderly. However, screening for vitamin B-12 deficiency is hampered by poor sensitivity of the existing total vitamin B-12 assay.
van Wijnen, Merel, Heiner-Fokkema, Rebecca M R, Muller Kobold, Anna; id_orcid, Pekelharing, J Maurits M, Sanders, Edward, Rammeloo, Ton, Trienekens, Paul H, Lindemans, Jan, Heil, Sandra G, Muller Kobold, Anna, de Jonge, Robert, Adriaansen, Henk J, de Rotte, Maurits C F J, Heiner-Fokkema, Rebecca M R; id_orcid   +13 more
core   +2 more sources