, 2020 Ab s t r Ac t Objective: This study is based on the comparison of the diagnostic accuracy of active B12 (holotranscobalamin) to total vitamin B12 (cobalamin) and verification of the active B12 test for clinical use.
B. Das, S. Bhatia, Poonam Pal
semanticscholar +2 more sources
Early biomarker response and patient preferences to oral and intramuscular vitamin B12 substitution in primary care: a randomised parallel-group trial [PDF]
Swiss Medical Weekly, 2017 BACKGROUND Vitamin B12 (VB12) deficiency can be treated with oral high-dose substitution or intramuscular (IM) injection of VB12. Whenever alternative routes of administration exist, patient preferences should be considered when choosing the ...
Corina Metaxas +5 more
doaj +4 more sources
Biochemical use of neurofilament light polypeptide and vitamin B12 in relation to diabetic polyneuropathy in Danish adolescents with type 1 diabetes: a cross-sectional study [PDF]
BMJ OpenIntroduction The aim of this study was to investigate serum Neurofilament Light polypeptide (NfL) as a biomarker for diabetic polyneuropathy (DPN) in adolescents with type 1 diabetes (T1D).
Jens Randel Nyengaard +7 more
doaj +2 more sources
Maternal Vitamin B12 in Pregnancy and Placental Development
Journal of Nutrition and MetabolismVitamin B12, or cobalamin, is an essential nutrient required for diverse physiological functions secondary to its role as a critical cofactor for two mammalian enzymes, methionine synthase and methylmalonyl-CoA mutase. While essential throughout all life
Amrita Arcot +4 more
doaj +2 more sources
Vitamin B12 status and the risk of developing sepsis in patients with bacterial infection: a prospective observational cohort study [PDF]
BMC MedicineBackground Data have shown that vitamin B12 has immunomodulatory effects via different pathways, which could influence the pathophysiology of sepsis. The objective of this study was to investigate whether vitamin B12 levels, assessed by the measurement ...
Andreas Pregernig +3 more
doaj +2 more sources
Low vitamin B-12 status in confirmed Alzheimer's disease as revealed by serum holotranscobalamin [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 2003 To examine the possible association of holotranscobalamin, the active fraction of serum cobalamin, with Alzheimer's disease.51 patients with pathologically confirmed Alzheimer's disease and 65 cognitively screened elderly controls were studied. Serum holotranscobalamin was measured by a new solid phase radioimmunoassay.Geometric mean levels showed no ...
Helga Refsum
openalex +4 more sources
Holotranscobalamin – An Early Marker for Laboratory Diagnosis of Vitamin B12 Deficiency [PDF]
European Oncology & Haematology, 2009 Vitamin B12deficiency is widespread. Among the population groups at risk are older people, vegetarians, pregnant women and patients with renal or intestinal diseases. The neurological symptoms of vitamin B12deficiency are unspecific and can be irreversible. Early detection is therefore important.
Wolfgang Herrmann +2 more
openalex +2 more sources
Assessing Diagnostic Accuracy of Serum Holotranscobalamin (Active-B12) in Comparison with Other Markers of Vitamin B12 Deficiency [PDF]
Indian Journal of Clinical Biochemistry, 2019 J. Bondu +3 more
semanticscholar +3 more sources
Development and Temporal Validation of Explainable Machine Learning Models for Predicting Vitamin B12 Deficiency Using Routine Laboratory Analytes [PDF]
DiagnosticsBackground/Objectives: Vitamin B12 deficiency is a prevalent yet frequently underdiagnosed condition, largely due to the limited diagnostic accuracy of serum total B12 and the restricted availability of confirmatory biomarkers such as holotranscobalamin ...
Ferhat Demirci +3 more
doaj +2 more sources