Results 51 to 60 of about 1,156,873 (300)

Distribution of HOMA-IR in Brazilian subjects with different body mass indexes [PDF]

Arquivos Brasileiros de Endocrinologia & Metabologia, 2006
IN THE CLINICAL SETTING, assessment of insulin resistance (IR) can be made without any laboratory test, but by evaluating data such as weight or BMI, among others. However, in the last few years laboratories have been asked to provide direct or indirect measures of IR.
Ghiringhello, Maria T., Vieira, José Gilberto H., Tachibana, Teresinha T., Ferrer, Cláudia, Maciel, Rui M.B., Amioka, Patrícia H.C., Hauache, Omar M., Oliveira, Cláudia H.M.C. de, Khawali, Cristina, Reis, André F.   +9 more
openaire   +3 more sources

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

The correlation between serum AMH and HOMA-IR among PCOS phenotypes [PDF]

BMC Research Notes, 2018
Polycystic ovarian syndrome (PCOS) is known to be one of the most prevalent endocrine disorders affecting reproductive age women. One of the endocrine disorder is hyperinsulinemia, which corresponds with the severity of PCOS. However, the pathogenesis of PCOS is not fully understood, but one theory of anti-mullerian hormone (AMH) has been proposed as ...
Budi Wiweko, Indra Indra, Cynthia Susanto, Muharam Natadisastra, Andon Hestiantoro   +4 more
openaire   +3 more sources

Resistência à insulina em adolescentes com e sem excesso de peso [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Desportos. Programa de Pós-Graduação em Educação Física.O aumento nas prevalências de excesso de peso entre adolescentes, principalmente devido aos altos índices de inatividade ...
Sigwalt, Fabia Rosa
core  

HOMA-IR levels for the different NAFLD groups for different BMI ranges.

, 2018
The population was stratified by BMI into the ranges 15–20, 20–25, 25–30, 30–35, and 35–40 kg/m2. No one in the HA NAFLD group had a BMI in the range 15–20 kg/m2.
Toshihiro Umehara (5390894)
core   +1 more source

HOMA-IR and HOMA2-IR estimation based on glycated hemoglobin as an alternative for fasting glucose

, 2023
BackgroundDiabetes mellitus is a major global public health problem. Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) is a key laboratory index in the assessment of insulin resistance. The calculation of HOMA-IR and its updated version HOMA2-
Verlinde, Evelyn, Maenhout, Thomas, Delanghe, Joris, Speeckaert, Marijn   +3 more
core   +1 more source

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

METS-IR/HOMA-IR and MAFLD in U.S. adults: dose–response correlation and the effect mediated by physical activity

BMC Endocrine Disorders
Objectives Metabolic dysfunction-associated fatty liver disease (MAFLD), a globally prevalent disease, is closely linked to insulin resistance (IR). Physical activity (PA) is closely linked to both MAFLD and IR.
Hongye Peng, Jingjing Xiang, Liang Pan, Mo Zhao, Bin Chen, Shuxia Huang, Ziang Yao, Jing Liu, Wenliang Lv   +8 more
doaj   +1 more source

Boxplots of HOMA-IR.

, 2015
Before log transformation to HOMA-IR, HOMA-IR has much skewed distribution. In contrasts, after log transformation, HOMA-IR has almost symmetric distribution.
Taesung Park (4438), Yongkang Kim (782506)   +1 more
core   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, EarlyView.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source