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Homeobox Genes and Orofacial Development
Connective Tissue Research, 1995The discovery of the homeobox as a highly conserved DNA-binding motif found in homeotic and other genes involved in the control of Drosophila development has dramatically changed developmental biology. It has now become clear that whereas morphologically Drosophila and mammalian embryos develop very differently, the genetic control of their development
Paul T Sharpe
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Current Biology, 1991
Recent highlights in vertebrate homeobox gene research include the discovery of new genes with novel expression patterns, observations that peptide growth factors and retinoic acid influence homeobox gene expression, and the generation of mutant phenotypes of embryos homozygous for null mutations. These combined studies reinforce the idea that homeobox
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Recent highlights in vertebrate homeobox gene research include the discovery of new genes with novel expression patterns, observations that peptide growth factors and retinoic acid influence homeobox gene expression, and the generation of mutant phenotypes of embryos homozygous for null mutations. These combined studies reinforce the idea that homeobox
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Current Opinion in Genetics & Development, 1997
To date, not many disorders have been associated with homeobox genes, especially with those belonging to the HOX family. This is particularly surprising, considering the body of evidence accumulated for a role of these genes in the control of mammalian development.
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To date, not many disorders have been associated with homeobox genes, especially with those belonging to the HOX family. This is particularly surprising, considering the body of evidence accumulated for a role of these genes in the control of mammalian development.
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Organization of human homeobox genes
Human Reproduction, 1988The chromosomal localization of 17 human homeoboxes and the predicted primary sequence of the encoded homeodomains is reported. These homeoboxes are clustered in four complex HOX loci on chromosomes 2, 7, 12 and 17. Although the identification of human homeoboxes has not been completed, existing data permit preliminary conclusions on the origin and ...
Edoardo Boncinelli +6 more
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Homeobox genes and heart development
Trends in Cardiovascular Medicine, 1995Genes encoding transcription factors are fundamental to developmental processes because their DNA-binding proteins can control expression of a multitude of genes. Therefore, activation of a single transcription factor gene can act as a genetic switch that controls the developmental destinies of groups of cells.
M J, Kern, E A, Argao, S S, Potter
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Gradient fields and homeobox genes
Development, 1991ABSTRACT We review here old experiments that defined the existence of morphogenetic gradient fields in vertebrate embryos. The rather abstract idea of cell fields of organforming potential has become less popular among modern developmental and molecular biologists.
E M, De Robertis, E A, Morita, K W, Cho
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Homeobox genes in vertebrate gastrulation
Current Opinion in Genetics & Development, 1995The formation and anteroposterior patterning of the three definitive germ layers, ectoderm, or epiblast, is the common theme of vertebrate gastrulation. What changes from system to system is the geometry of these events and the nature of the non-epiblast transient structures implicated.
BONCINELLI E, Mallamaci, Antonio
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Homeobox genes and axial patterning
Cell, 1992William McGinnis* and Robb Krumiauft *Department of Molecular Biophysics and Biochemistry Yale University New Haven, Connecticut 06511 tNationai institute for Medical Research Mill Hill London NW7 1AA England Animal embryos need to specify different cell types, and the genetic functions that provide such controls are easy to comprehend since they ...
William McGinnis, RobB Krumlauf
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Biochemical Genetics, 1994
We report the isolation of nine rat cognates of mouse homeoboxes within the four Hox gene clusters and a rat homologue of mouse IPF1 homeobox, RHbox#13A. The sequences of nine cloned homeoboxes are highly similar to those of the mouse and human homeoboxes in the Hox clusters. The restriction enzyme sites and map distances between each of the homeoboxes
Y, Sakoyama +3 more
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We report the isolation of nine rat cognates of mouse homeoboxes within the four Hox gene clusters and a rat homologue of mouse IPF1 homeobox, RHbox#13A. The sequences of nine cloned homeoboxes are highly similar to those of the mouse and human homeoboxes in the Hox clusters. The restriction enzyme sites and map distances between each of the homeoboxes
Y, Sakoyama +3 more
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The role of homeobox genes in hematopoiesis
Biotherapy, 1998Homeobox genes encode transcription factors containing a common DNA-binding motif found in virtually all animal species. Different homeobox gene families have evolved which encode homeodomains of different types or classes and thus far approximately 170 homeobox genes have been cloned. Homeoproteins are involved in the control of animal development and
Magli, MC
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