Results 91 to 100 of about 55,050 (178)

Clinical Epigenomics in Rare Diseases: Interpreting DNA Methylation Episignatures

Molecular Genetics &Genomic Medicine, Volume 14, Issue 10, October 2026.
Clinical epigenomics extends rare‐disease diagnostics beyond DNA sequence by revealing the downstream regulatory consequences of genetic variation. DNA methylation episignatures provide functional evidence that can support diagnosis, refine variant interpretation, distinguish overlapping disorders, and complement genomic, and multi‐omic testing ...
Himanshu Goel, Shuxiang Goh, Luke Stuart
wiley   +1 more source

RNA recognition and translational regulation by a homeodomain protein

, 1996
In Drosophila, the primary determinant of anterior pattern is the gradient morphogen bicoid (bcd), a homeodomain protein that binds DNA and transcriptionally activates target genes at different threshold concentrations.
Dubnau, J. T., Struhl, G., Josh Dubnau, Gary Struhl   +3 more
core   +1 more source

Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances

Andrology, Volume 14, Issue 7, Page 1962-1970, October 2026.
ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan   +4 more
wiley   +1 more source

Role of the tomato MARS1/ROUGH gene encoding a LYSINE‐SPECIFIC HISTONE DEMETHYLASE 1 in adventitious root and fruit skin formation

Journal of Integrative Plant Biology, Volume 68, Issue 10, Page 3644-3669, October 2026.
The tomato mars1/rough mutant displays enhanced root regeneration and rough fruits due to ectopic cell proliferation. The causal gene encodes a lysine‐specific histone demethylase that normally maintains gene silencing. Its loss alters histone methylation, upregulating several genes, including those B‐type cyclins involved in tissue‐specific cellular ...
Eduardo Larriba, Cécile Bres, Aurora Alaguero‐Cordovilla, Riyazuddin Riyazuddin, Qingyi Wang, Johann Petit, Jean‐Philippe Mauxion, Lara Caballero, David Latrasse, Bénédicte Bakan, Rim Brik‐Chaouche, David Esteve‐Bruna, Moussa Benhamed, Christophe Rothan, José Manuel Pérez‐Pérez   +14 more
wiley   +1 more source

Nuclear magnetic resonance solution structure of the fushi tarazu homeodomain from Drosophila and comparison with the Antennapedia homeodomain.

, 1994
The three-dimensional structure of a recombinant 70-residue polypeptide containing the complete fushi tarazu (ftz) homeodomain from Drosophila melanogaster has been determined by nuclear magnetic resonance (NMR) spectroscopy in solution.
Müller M, Gehring WJ, Wüthrich K, Qian YQ, Resendez-Perez D, Furukubo-Tokunaga K   +5 more
core   +1 more source

Combinatorial cis‐regulatory elements shape temporal effector expression in Ustilago maydis

Molecular Plant Pathology, Volume 27, Issue 10, October 2026.
We identified promoter motifs associated with infection phases in Ustilago maydis and analysed their positional distribution relative to transcription start sites and generated a synthetic minimal promoter that drives in‐plant gene expression. ABSTRACT Plant‐pathogenic fungi secrete small proteins, termed effectors, to reprogramme host metabolism and ...
Georgios Saridis, Janina Werner, Katharina Stein, Luyao Huang, Ute Meyer, Jan Muelhoefer, Namarta C. Singh, Gunther Doehlemann   +7 more
wiley   +1 more source

Differential control of transcription by homologous homeodomain coregulators

, 1996
The human herpes simplex virus type 1 (HSV-1) transactivator VP16 and its homolog from bovine herpes-virus 1 (BHV-1) can each recruit the human homeodomain protein Oct-1 into a transcriptional regulatory complex.
Huang, C. C., Herr, W.
core  

A laser capture microdissection‐based transcriptome analysis on salt glands highlights salt secretion mechanism in mangrove plant Avicennia marina

The Plant Journal, Volume 128, Issue 1, October 2026.
SUMMARY Salt glands, developed in the epidermis of salt‐secreting mangrove plant Avicennia marina leaves and specialized in salt secretion, are critical for improving the survival under high saline habitats. However, the salt secretion mechanism in A. marina remains poorly understood. In this study, laser capture microdissection was employed to isolate
Ming‐Yue Wei, Ling Sun, Li‐Han Zhuang, Xing‐Yue Hong, Ze‐Jun Guo, Huan Li, Hezi Huang, Lu‐Dan Zhang, Dong‐Na Ma, Zhi‐Jun Shen, Xiu‐Xiu Wang, Xue‐Yi Zhu, Han‐Chen Tang, Hai‐Lei Zheng   +13 more
wiley   +1 more source

Defective Msx1 Nuclear Translocation Underlies Severe Oligodontia

International Dental Journal
Aim or purpose: This study aimed to elucidate the mechanism by which MSX1 variants contribute to nonsyndromic tooth agenesis (NSTA) and determine how variant domains correlate with tooth loss severity.
Jing Sun, Chen Yiqi, Zhang Caiqi
doaj   +1 more source

Functional specificity of the Antennapedia homeodomain

, 1993
The segmental identity in animal development is determined by a set of homeotic selector genes clustered in the invertebrate HOM or vertebrate Hox homeo box complexes.
Flister, S., Furukubo-Tokunaga, K., Gehring, W. J.   +2 more
core