Results 11 to 20 of about 3,024,874 (379)
Copper homeostasis and cuproptosis in health and disease
Signal Transduction and Targeted Therapy, 2022 As an essential micronutrient, copper is required for a wide range of physiological processes in virtually all cell types. Because the accumulation of intracellular copper can induce oxidative stress and perturbing cellular function, copper homeostasis ...
Liyun Chen, J. Min, Fudi Wang
semanticscholar +1 more source
Clinical Journal of the American Society of Nephrology, 2015 Alterations in water homeostasis can disturb cell size and function. Although most cells can internally regulate cell volume in response to osmolar stress, neurons are particularly at risk given a combination of complex cell function and space restriction within the calvarium. Thus, regulating water balance is fundamental to survival.
John, Danziger, Mark L, Zeidel
openaire +2 more sources
Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis
International Journal of Molecular Sciences, 2022 Regulated cell death (RCD) has a significant impact on development, tissue homeostasis, and the occurrence of various diseases. Among different forms of RCD, ferroptosis is considered as a type of reactive oxygen species (ROS)-dependent regulated ...
L. Rochette +5 more
semanticscholar +1 more source
Signal Transduction and Targeted Therapy, 2022 Disturbed cholesterol homeostasis plays critical roles in the development of multiple diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and cancers, particularly the CVD in which the accumulation of lipids (mainly the ...
Yajun Duan +5 more
semanticscholar +1 more source
Loss-of-function of sox3 causes follicle development retardation and reduces fecundity in zebrafish
Protein & Cell, 2018 Folliculogenesis is essential for production of female gametes in vertebrates. However, the molecular mechanisms underlying follicle development, particularly apoptosis regulation in ovary, remain elusive. Here, we generated sox3 knockout zebrafish lines
Qiang Hong +7 more
doaj +1 more source
Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut [PDF]
, 2015 Adult tissue homeostasis requires a tight balance between the removal of old or damaged cells and the production of new ones. Such processes are usually driven by dedicated stem cells that reside within specific tissue locations or niches.
Carroll, Lynsey +2 more
core +1 more source
Current Biology, 2014 Epithelia form intelligent, dynamic barriers between the external environment and an organism's interior. Intercellular cadherin-based adhesions adapt and respond to mechanical forces and cell density, while tight junctions flexibly control diffusion both within the plasma membrane and between adjacent cells. Epithelial integrity and homeostasis are of
Macara, Ian G. +4 more
openaire +2 more sources
Role of mitochondrial reactive oxygen species in homeostasis regulation
Redox Report, 2022 Mitochondria are the main source of reactive oxygen species (ROS) in cells. Early studies have shown that mitochondrial reactive oxygen species (mROS) are related to the occurrence and adverse outcomes of many diseases, and are thus regarded as an ...
Bao-Yi Zhang +7 more
semanticscholar +1 more source
METTL3 regulates WTAP protein homeostasis [PDF]
, 2018 The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Capuano, Ernestina +8 more
core +2 more sources
Risk homeostasis in information security:challenges in confirming existence and verifying impact [PDF]
, 2017 The central premise behind risk homeostasis theory is that humans adapt their behaviors, based on external factors, to align with a personal risk tolerance level.
Renaud, Karen, Warkentin, Merrill
core +2 more sources