Results 31 to 40 of about 2,649,250 (302)

N4-Cytosine DNA Methylation Is Involved in the Maintenance of Genomic Stability in Deinococcus radiodurans

Frontiers in Microbiology, 2019
DNA methylation serves as a vital component of restriction-modification (R-M) systems in bacteria, where it plays a crucial role in defense against foreign DNA.
Shengjie Li, Jianling Cai, Huizhi Lu, Shuyu Mao, Shang Dai, Jing Hu, Liangyan Wang, Xiaoting Hua, Hong Xu, Bing Tian, Ye Zhao, Yuejin Hua   +11 more
doaj   +1 more source

A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

Nature Communications, 2023
Glial cells have been proposed as a source of neural progenitors, but the mechanisms underpinning the neurogenic potential of adult glia are not known.
Anna Laddach, Song Hui Chng, Reena Lasrado, Fränze Progatzky, Michael Shapiro, Alek Erickson, Marisol Sampedro Castaneda, Artem V. Artemov, Ana Carina Bon-Frauches, Eleni-Maria Amaniti, Jens Kleinjung, Stefan Boeing, Sila Ultanir, Igor Adameyko, Vassilis Pachnis   +14 more
doaj   +1 more source

Pink1 and Parkin regulate Drosophila intestinal stem cell proliferation during stress and aging. [PDF]

, 2017
Intestinal stem cells (ISCs) maintain the midgut epithelium in Drosophila melanogaster Proper cellular turnover and tissue function rely on tightly regulated rates of ISC division and appropriate differentiation of daughter cells.
Abramov, Amcheslavsky, Amcheslavsky, Amcheslavsky, Benard, Biteau, Biteau, Biteau, Buchon, Buchon, Buchon, Christopher L. Koehler, Clark, Clarkson, Coppé, Correia-Melo, D. Leanne Jones, Deng, Greene, Guo, Guy A. Perkins, Hackenbrock, Han, Henchcliffe, Hochmuth, Hur, Jiang, Jiang, Jones, Kashatus, Lee, Lee, Li, Liu, Maeda, Marianes, Mark H. Ellisman, McGuire, Micchelli, Myant, Nakamura, Nicholson, Ohlstein, Ohlstein, Osterwalder, O’Brien, Park, Passos, Poole, Poole, Rana, Rera, Resende, Resnik-Docampo, Roman, Springer, Sykiotis, Takashima, Tian, Twig, Wang, Wang, Wei, Westermann, Yang, Youle, Zeng, Zeng, Zhu   +68 more
core   +1 more source

Synovial tissue macrophages: friend or foe? [PDF]

, 2017
Healthy synovial tissue includes a lining layer of synovial fibroblasts and macrophages. The influx of leucocytes during active rheumatoid arthritis (RA) includes monocytes that differentiate locally into proinflammatory macrophages, and these produce ...
Alivernini, Stefano, Kurowska-Stolarska, Mariola   +1 more
core   +2 more sources

The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells

Journal of Experimental & Clinical Cancer Research, 2018
Background Tetrandrine is a bisbenzylisoquinoline alkaloid isolated from the Chinese medicinal herb Stephania tetrandra S. Moore. We previously demonstrated that tetrandrine exhibits potent antitumor effects in many types of cancer cells.
Zhenxing Zhang, Ting Liu, Man Yu, Kangdi Li, Wenhua Li   +4 more
doaj   +1 more source

Deficiency of Capicua disrupts bile acid homeostasis [PDF]

, 2018
Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown.
Choi, N, Fryer, JD, Hwang, D, Jung, HY, Kang, H, Kim, E, KIM, KYONG TAI, Kim, S, Lee, J, LEE, YOONTAE, Park, S, Yoe, J, Zoghbi, HY   +12 more
core   +2 more sources

The Zinc Finger Transcription Factor Fts2 Represses the Yeast-to-Filament Transition in the Dimorphic Yeast Yarrowia lipolytica

mSphere, 2022
The yeast-to-filament transition is an important cellular response to environmental stimulations in dimorphic fungi. In addition to activators, there are repressors in the cells to prevent filament formation, which is important to keep the cells in the ...
Jia-Wen Chen, Yi-Sheng Mao, Lv-Qiao Yan, Xiang-Dong Gao   +3 more
doaj   +1 more source

Investigating the properties of bio-chemical networks of artificial organisms with opposing behaviours [PDF]

, 2013
Organisms, be it singled-celled organisms or multi-cellular organisms, are constantly faced with opposing objectives requiring different sets of behaviours.
Mokhtar, Maizura
core   +1 more source

Conserved and Noncanonical Activities of Two Histone H3K36 Methyltransferases Required for Insect-Pathogenic Lifestyle of Beauveria bassiana

Journal of Fungi, 2021
Set2 and Ash1 are histone methyltransferases (KMTs) in the KMT3 family normally used to catalyze methylation of histone H3K36 (H3K36me) but remain unexplored in fungal insect pathogens.
Kang Ren, Ya-Ni Mou, Sheng-Hua Ying, Ming-Guang Feng   +3 more
doaj   +1 more source

Long‐Term Administration of Eicosapentaenoic Acid Improves Post–Myocardial Infarction Cardiac Remodeling in Mice by Regulating Macrophage Polarization

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundConsumption of n‐3 fatty acids reduces the incidence of cardiovascular mortality in populations that consume diets rich in fish oil. Eicosapentaenoic acid (EPA) is an n‐3 fatty acid known to reduce the frequency of nonfatal coronary events ...
Masayuki Takamura, Keisuke Kurokawa, Hiroshi Ootsuji, Oto Inoue, Hikari Okada, Ayano Nomura, Shuichi Kaneko, Soichiro Usui   +7 more
doaj   +1 more source