Results 31 to 40 of about 372,766 (265)

Investigating the relation between Stochastic Differentiation, Homeostasis and Clonal Expansion in Intestinal Crypts via Multiscale Modeling [PDF]

, 2014
Colorectal tumors originate and develop within intestinal crypts. Even though some of the essential phenomena that characterize crypt structure and dynamics have been effectively described in the past, the relation between the differentiation process and
De Matteis Giovanni, De Matteis G, Graudenzi Alex, Caravagna Giulio, De Matteis, Giovanni, Antoniotti, Marco, Giulio Caravagna (380492), Graudenzi, Alex, Antoniotti M, Alex Graudenzi (569252), Graudenzi A, Caravagna G, Caravagna, Giulio, Marco Antoniotti, Giovanni De Matteis, Giovanni De Matteis (5659246), Giulio Caravagna, Antoniotti Marco, Alex Graudenzi, Marco Antoniotti (66901)   +19 more
core   +1 more source

The plant alkaloid tetrandrine inhibits metastasis via autophagy-dependent Wnt/β-catenin and metastatic tumor antigen 1 signaling in human liver cancer cells

Journal of Experimental & Clinical Cancer Research, 2018
Background Tetrandrine is a bisbenzylisoquinoline alkaloid isolated from the Chinese medicinal herb Stephania tetrandra S. Moore. We previously demonstrated that tetrandrine exhibits potent antitumor effects in many types of cancer cells.
Zhenxing Zhang, Ting Liu, Man Yu, Kangdi Li, Wenhua Li   +4 more
doaj   +1 more source

Homeostasis and Narcolepsy [PDF]

Sleep, 1994
Narcolepsy is characterized by irresistible daytime sleep episodes and cataplectic attacks. Because of the finding of an ultradian rhythmicity of slow-wave sleep in narcolepsy, an alteration of nonrapid eye movement sleep homeostatic regulation has been hypothesized to explain the impairment of the sleep-wakefulness cycle. This hypothesis was tested by
A, Besset, M, Tafti, L, Nobile, M, Billiard   +3 more
openaire   +2 more sources

Long‐Term Administration of Eicosapentaenoic Acid Improves Post–Myocardial Infarction Cardiac Remodeling in Mice by Regulating Macrophage Polarization

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundConsumption of n‐3 fatty acids reduces the incidence of cardiovascular mortality in populations that consume diets rich in fish oil. Eicosapentaenoic acid (EPA) is an n‐3 fatty acid known to reduce the frequency of nonfatal coronary events ...
Masayuki Takamura, Keisuke Kurokawa, Hiroshi Ootsuji, Oto Inoue, Hikari Okada, Ayano Nomura, Shuichi Kaneko, Soichiro Usui   +7 more
doaj   +1 more source

SETD4 Confers Cancer Stem Cell Chemoresistance in Nonsmall Cell Lung Cancer Patients via the Epigenetic Regulation of Cellular Quiescence

Stem Cells International, 2023
Increasing evidence indicates that quiescent cancer stem cells (CSCs) are a root cause of chemoresistance. SET domain-containing protein 4 (SETD4) epigenetically regulates cell quiescence in breast cancer stem cells (BCSCs), and SETD4-positive BCSCs are ...
Yuehong Wang, Yuman Yu, Weijun Yang, Linying Wu, Yaoshun Yang, Qianyun Lu, Jianying Zhou   +6 more
doaj   +1 more source

Genome-Wide Insight into Profound Effect of Carbon Catabolite Repressor (Cre1) on the Insect-Pathogenic Lifecycle of Beauveriabassiana

Journal of Fungi, 2021
Carbon catabolite repression (CCR) is critical for the preferential utilization of glucose derived from environmental carbon sources and regulated by carbon catabolite repressor A (Cre1/CreA) in filamentous fungi.
Rehab Abdelmonem Mohamed, Kang Ren, Ya-Ni Mou, Sheng-Hua Ying, Ming-Guang Feng   +4 more
doaj   +1 more source

Homeostasis and synaptic scaling : a theoretical perspective [PDF]

, 2013
textAbstract The synaptic input received by neurons in cortical circuits is in constant flux. From both environmental sensory changes and learning mechanisms that modify synaptic strengths, the excitatory and inhibitory signals received by a post ...
Corey, Joseph Harrod
core  

AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons [PDF]

, 2007
Hypothalamic AMP-activated protein kinase (AMPK) has been suggested to act as a key sensing mechanism, responding to hormones and nutrients in the regulation of energy homeostasis.
Carling, D., Choudhury, Agharul I., Smith, Mark A., Fryer, L.G.D., Speakman, J.R., Ashford, MLJ, Carling, D, Withers, DJ, Selman, Colin, Xu, Allison W., Al-Qassab, H, Fryer, Lee G.D., Vaulont, Sophie, Choudhury, AI, Fryer, LGD, Vaulont, S., Claret, Marc, Heffron, H, Speakman, John R., Heffron, H., Barsh, Gregory S., Clements, M, Choudhury, A.I., Vaulont, S, Heffron, Helen, Xu, A.W., Withers, D.J., Viollet, B, Smith, MA, Barsh, G.S., Clements, Melanie, Withers, Dominic J., Viollet, B., Ashford, Michael L. J.; id_orcid, Batterham, RL, Selman, C, Claret, M., Barsh, GS, Claret, M, Selman, C., Al-Qassab, H., Xu, AW, Al-Qassab, Hind, Viollet, Benoit, Smith, M.A., Ashford, M.L.J., Batterham, R.L., Batterham, Rachel L., Carling, David, Speakman, JR, Clements, M.   +50 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Conserved and Noncanonical Activities of Two Histone H3K36 Methyltransferases Required for Insect-Pathogenic Lifestyle of Beauveria bassiana

Journal of Fungi, 2021
Set2 and Ash1 are histone methyltransferases (KMTs) in the KMT3 family normally used to catalyze methylation of histone H3K36 (H3K36me) but remain unexplored in fungal insect pathogens.
Kang Ren, Ya-Ni Mou, Sheng-Hua Ying, Ming-Guang Feng   +3 more
doaj   +1 more source