Loss-of-function of sox3 causes follicle development retardation and reduces fecundity in zebrafish
Protein & Cell, 2018 Folliculogenesis is essential for production of female gametes in vertebrates. However, the molecular mechanisms underlying follicle development, particularly apoptosis regulation in ovary, remain elusive. Here, we generated sox3 knockout zebrafish lines
Qiang Hong +7 more
doaj +1 more source
Risk homeostasis in information security:challenges in confirming existence and verifying impact [PDF]
, 2017 The central premise behind risk homeostasis theory is that humans adapt their behaviors, based on external factors, to align with a personal risk tolerance level.
Renaud, Karen, Warkentin, Merrill
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Regulation of genes involved in carnitine homeostasis by PPARa across different species (rat, mouse, pig, cattle, chicken, and human) [PDF]
, 2012 Recent studies in rodents convincingly demonstrated that PPAR-alpha is a key regulator of genes involved in carnitine homeostasis, which serves as a reasonable explanation for the phenomenon that energy deprivation and fibrate treatment, both of which ...
Egeri, Leonie +4 more
core +1 more source
The hyper-activation of transcriptional enhancers in breast cancer
Clinical Epigenetics, 2019 Background Activation of transcription enhancers, especially super-enhancers, is one of the critical epigenetic features of tumorigenesis. However, very few studies have systematically identified the enhancers specific in cancer tissues. Methods Here, we
Qing-Lan Li +8 more
doaj +1 more source
Cellular fate of intersex differentiation
Cell Death and Disease, 2021 Infertile ovotestis (mixture of ovary and testis) often occurs in intersex individuals under certain pathological and physiological conditions. However, how ovotestis is formed remains largely unknown.
Xin Wang +6 more
doaj +1 more source
Microbiology Spectrum, 2023 Bacteria are constantly exposed to a variety of environmental stresses. Temperature is considered one of the most important environmental factors affecting microbial growth and survival.
Yihan Wang +5 more
doaj +1 more source
Wnt signalling in intestinal stem cells: lessons from mice and flies [PDF]
, 2018 Adult stem cells play critical roles in the basal maintenance of tissue integrity, also known as homeostasis, and in tissue regeneration following damage. The highly conserved Wnt signalling pathway is a key regulator of stem cell fate.
Carroll, Lynsey +2 more
core +2 more sources
Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis [PDF]
, 2020 Strategies for controlled delivery of therapeutic siRNA into living cells are in high demand as endosomal escape remains the most prominent bottleneck at the intracellular level.
Barriga, Gerardo Garcia-Diaz +16 more
core +3 more sources
Telomerase regulation by the long non-coding RNA H19 in human acute promyelocytic leukemia cells
Molecular Cancer, 2018 Background Since tumor growth requires reactivation of telomerase (hTERT), this enzyme is a challenging target for drug development. Therefore, it is of great interest to identify telomerase expression and activity regulators.
Joëlle El Hajj +6 more
doaj +1 more source
An optimized base editor with efficient C-to-T base editing in zebrafish
BMC Biology, 2020 Background Zebrafish is a model organism widely used for the understanding of gene function, including the fundamental basis of human disease, enabled by the presence in its genome of a high number of orthologs to human genes.
Yu Zhao +4 more
doaj +1 more source