Results 11 to 20 of about 2,030,514 (219)

Characterization of Hsp17, a Novel Small Heat Shock Protein, in Sphingomonas melonis TY under Heat Stress

Microbiology Spectrum, 2023
Bacteria are constantly exposed to a variety of environmental stresses. Temperature is considered one of the most important environmental factors affecting microbial growth and survival.
Yihan Wang, Xiaoyu Wang, Hao Wu, Lvjing Wang, Haixia Wang, Zhenmei Lu   +5 more
doaj   +1 more source

Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy

Journal of Experimental & Clinical Cancer Research, 2018
Background Tetrandrine, a bisbenzylisoquinoline alkaloid that was isolated from the medicinal plant Stephania tetrandrine S. Moore, was recently identified as a novel chemotherapy drug. Tetrandrine exhibited a potential antitumor effect on multiple types
Man Yu, Ting Liu, Yicheng Chen, Yafang Li, Wenhua Li   +4 more
doaj   +1 more source

An optimized base editor with efficient C-to-T base editing in zebrafish

BMC Biology, 2020
Background Zebrafish is a model organism widely used for the understanding of gene function, including the fundamental basis of human disease, enabled by the presence in its genome of a high number of orthologs to human genes.
Yu Zhao, Dantong Shang, Ruhong Ying, Hanhua Cheng, Rongjia Zhou   +4 more
doaj   +1 more source

Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2

Nature Communications, 2020
The protein Insig-2 negatively regulates lipid biosynthesis and is short-lived in liver cells but stable in muscle cells. Here, the authors show that in muscle cells producing reactive oxygen species, there is increased oxidation compared to ...
Zhang-Sen Zhou, Mei-Xin Li, Jie Liu, Hengwu Jiao, Jing-Ming Xia, Xiong-Jie Shi, Huabin Zhao, Liping Chu, Jingrong Liu, Wei Qi, Jie Luo, Bao-Liang Song   +11 more
doaj   +1 more source

A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia

Nature Communications, 2023
Glial cells have been proposed as a source of neural progenitors, but the mechanisms underpinning the neurogenic potential of adult glia are not known.
Anna Laddach, Song Hui Chng, Reena Lasrado, Fränze Progatzky, Michael Shapiro, Alek Erickson, Marisol Sampedro Castaneda, Artem V. Artemov, Ana Carina Bon-Frauches, Eleni-Maria Amaniti, Jens Kleinjung, Stefan Boeing, Sila Ultanir, Igor Adameyko, Vassilis Pachnis   +14 more
doaj   +1 more source

Thiamine-Mediated Microbial Interaction between Auxotrophic Rhodococcus ruber ZM07 and Prototrophic Cooperators in the Tetrahydrofuran-Degrading Microbial Community H-1

Microbiology Spectrum, 2023
As a crucial growth factor, thiamine can regulate functional microbial communities; however, our current understanding of its effect on bioremediation is lacking. Using metatranscriptome and 16S rRNA gene sequencing, we explored the mechanism of response
Hui Huang, Hao Wu, Minbo Qi, Haixia Wang, Zhenmei Lu   +4 more
doaj   +1 more source

N4-Cytosine DNA Methylation Is Involved in the Maintenance of Genomic Stability in Deinococcus radiodurans

Frontiers in Microbiology, 2019
DNA methylation serves as a vital component of restriction-modification (R-M) systems in bacteria, where it plays a crucial role in defense against foreign DNA.
Shengjie Li, Jianling Cai, Huizhi Lu, Shuyu Mao, Shang Dai, Jing Hu, Liangyan Wang, Xiaoting Hua, Hong Xu, Bing Tian, Ye Zhao, Yuejin Hua   +11 more
doaj   +1 more source

The Zinc Finger Transcription Factor Fts2 Represses the Yeast-to-Filament Transition in the Dimorphic Yeast Yarrowia lipolytica

mSphere, 2022
The yeast-to-filament transition is an important cellular response to environmental stimulations in dimorphic fungi. In addition to activators, there are repressors in the cells to prevent filament formation, which is important to keep the cells in the ...
Jia-Wen Chen, Yi-Sheng Mao, Lv-Qiao Yan, Xiang-Dong Gao   +3 more
doaj   +1 more source

Long‐Term Administration of Eicosapentaenoic Acid Improves Post–Myocardial Infarction Cardiac Remodeling in Mice by Regulating Macrophage Polarization

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundConsumption of n‐3 fatty acids reduces the incidence of cardiovascular mortality in populations that consume diets rich in fish oil. Eicosapentaenoic acid (EPA) is an n‐3 fatty acid known to reduce the frequency of nonfatal coronary events ...
Masayuki Takamura, Keisuke Kurokawa, Hiroshi Ootsuji, Oto Inoue, Hikari Okada, Ayano Nomura, Shuichi Kaneko, Soichiro Usui   +7 more
doaj   +1 more source

SETD4 Confers Cancer Stem Cell Chemoresistance in Nonsmall Cell Lung Cancer Patients via the Epigenetic Regulation of Cellular Quiescence

Stem Cells International, 2023
Increasing evidence indicates that quiescent cancer stem cells (CSCs) are a root cause of chemoresistance. SET domain-containing protein 4 (SETD4) epigenetically regulates cell quiescence in breast cancer stem cells (BCSCs), and SETD4-positive BCSCs are ...
Yuehong Wang, Yuman Yu, Weijun Yang, Linying Wu, Yaoshun Yang, Qianyun Lu, Jianying Zhou   +6 more
doaj   +1 more source