Results 11 to 20 of about 372,766 (265)

Adaptive cell invasion maintains lateral line organ homeostasis in response to environmental changes

, 2021
Mammalian inner ear and fish lateral line sensory hair cells (HCs) detect fluid motion to transduce environmental signals. Actively maintained ionic homeostasis of the mammalian inner ear endolymph is essential for HC function.
Romero Carvajal, Marco Andrés
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Risk homeostasis theory - A study of intrinsic compensation [PDF]

, 1996
Risk homeostasis theory (RHT) suggests that changes made to the intrinsic risk of environments are negated in one of three ways: behavioural adjustments within the environment, mode migration, and avoidance of the physical risk.
Hoyes, TW, Stanton, Neville A., Taylor, R.G., Stanton, NA, Taylor, RG, Hoyes, Thomas W.   +5 more
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The hyper-activation of transcriptional enhancers in breast cancer

Clinical Epigenetics, 2019
Background Activation of transcription enhancers, especially super-enhancers, is one of the critical epigenetic features of tumorigenesis. However, very few studies have systematically identified the enhancers specific in cancer tissues. Methods Here, we
Qing-Lan Li, Dan-Ya Wang, Lin-Gao Ju, Jie Yao, Chuan Gao, Pin-Ji Lei, Lian-Yun Li, Xiao-Lu Zhao, Min Wu   +8 more
doaj   +1 more source

Integrative concept of homeostasis: translating physiology into medicine [PDF]

, 2011
To truly understand living systems they must be viewed as a whole. In order to achieve this and to come to some law to which living systems obey, data obtained on cells, tissues and organs should be integrated.
Ivan Spasojevic
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Telomerase regulation by the long non-coding RNA H19 in human acute promyelocytic leukemia cells

Molecular Cancer, 2018
Background Since tumor growth requires reactivation of telomerase (hTERT), this enzyme is a challenging target for drug development. Therefore, it is of great interest to identify telomerase expression and activity regulators.
Joëlle El Hajj, Eric Nguyen, Qingyuan Liu, Claire Bouyer, Eric Adriaenssens, George Hilal, Evelyne Ségal-Bendirdjian   +6 more
doaj   +1 more source

Characterization of Hsp17, a Novel Small Heat Shock Protein, in Sphingomonas melonis TY under Heat Stress

Microbiology Spectrum, 2023
Bacteria are constantly exposed to a variety of environmental stresses. Temperature is considered one of the most important environmental factors affecting microbial growth and survival.
Yihan Wang, Xiaoyu Wang, Hao Wu, Lvjing Wang, Haixia Wang, Zhenmei Lu   +5 more
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Combination therapy with protein kinase inhibitor H89 and Tetrandrine elicits enhanced synergistic antitumor efficacy

Journal of Experimental & Clinical Cancer Research, 2018
Background Tetrandrine, a bisbenzylisoquinoline alkaloid that was isolated from the medicinal plant Stephania tetrandrine S. Moore, was recently identified as a novel chemotherapy drug. Tetrandrine exhibited a potential antitumor effect on multiple types
Man Yu, Ting Liu, Yicheng Chen, Yafang Li, Wenhua Li   +4 more
doaj   +1 more source

Mining genomes of marine cyanobacteria for elements of zinc homeostasis [PDF]

, 2012
Zinc is a recognized essential element for the majority of organisms, and is indispensable for the correct function of hundreds of enzymes and thousands of regulatory proteins.
Schmid, Ralf, A. Millard (3584540), Ksibe, Amira Z., Andrew eMillard, James P. Barnett, Amira Z. Ksibe, D. J. Scanlan (7640840), A. Z. Ksibe (7640837), David J. Scanlan, Amira eKsibe, J. P. Barnett (7640834), Barnett, James P., Ralf eSchmid, Scanlan, David J., James P. Barnett, Millard, Andrew D., Blindauer, Claudia A., James P Barnett, R. Schmid (7606553), C. A. Blindauer (7640843), Claudia Andrea Blindauer, Andrew Millard, David J Scanlan, Ralf Schmid   +23 more
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An optimized base editor with efficient C-to-T base editing in zebrafish

BMC Biology, 2020
Background Zebrafish is a model organism widely used for the understanding of gene function, including the fundamental basis of human disease, enabled by the presence in its genome of a high number of orthologs to human genes.
Yu Zhao, Dantong Shang, Ruhong Ying, Hanhua Cheng, Rongjia Zhou   +4 more
doaj   +1 more source

Bone homeostasis [PDF]

Proceedings of the National Academy of Sciences, 1998
The functions of bone(s) are (i) mechanical support of soft tissues, (ii) levers for muscle action, (iii) protection of the central nervous system, (iv) release of calcium and other ions for the maintenance of a constant ionic environment in the extracellular fluid, and (v) housing and support of hemopoiesis.
openaire   +2 more sources