Results 21 to 30 of about 3,024,874 (379)
The hyper-activation of transcriptional enhancers in breast cancer
Clinical Epigenetics, 2019 Background Activation of transcription enhancers, especially super-enhancers, is one of the critical epigenetic features of tumorigenesis. However, very few studies have systematically identified the enhancers specific in cancer tissues. Methods Here, we
Qing-Lan Li +8 more
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Cellular fate of intersex differentiation
Cell Death and Disease, 2021 Infertile ovotestis (mixture of ovary and testis) often occurs in intersex individuals under certain pathological and physiological conditions. However, how ovotestis is formed remains largely unknown.
Xin Wang +6 more
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Integrative concept of homeostasis: translating physiology into medicine [PDF]
, 2011 To truly understand living systems they must be viewed as a whole. In order to achieve this and to come to some law to which living systems obey, data obtained on cells, tissues and organs should be integrated.
Ivan Spasojevic, Ivan Spasojevic
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Telomerase regulation by the long non-coding RNA H19 in human acute promyelocytic leukemia cells
Molecular Cancer, 2018 Background Since tumor growth requires reactivation of telomerase (hTERT), this enzyme is a challenging target for drug development. Therefore, it is of great interest to identify telomerase expression and activity regulators.
Joëlle El Hajj +6 more
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Microbiology Spectrum, 2023 Bacteria are constantly exposed to a variety of environmental stresses. Temperature is considered one of the most important environmental factors affecting microbial growth and survival.
Yihan Wang +5 more
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Hepcidin and iron homeostasis during pregnancy. [PDF]
, 2014 Hepcidin is the master regulator of systemic iron bioavailability in humans. This review examines primary research articles that assessed hepcidin during pregnancy and postpartum and report its relationship to maternal and infant iron status and birth ...
Cadwell, Brooke +4 more
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British Medical Bulletin, 2000 There is a wealth of experimental and clinical information showing that hypertension, hyperglycaemia, hyperthermia and intracranial hypertension are each independent indicators of a poor prognosis after stroke, but there is an astonishing lack of evidence from randomised controlled trials to tell us how to manage these problems, bearing in mind their ...
openaire +2 more sources
An optimized base editor with efficient C-to-T base editing in zebrafish
BMC Biology, 2020 Background Zebrafish is a model organism widely used for the understanding of gene function, including the fundamental basis of human disease, enabled by the presence in its genome of a high number of orthologs to human genes.
Yu Zhao +4 more
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Nature Communications, 2020 The protein Insig-2 negatively regulates lipid biosynthesis and is short-lived in liver cells but stable in muscle cells. Here, the authors show that in muscle cells producing reactive oxygen species, there is increased oxidation compared to ...
Zhang-Sen Zhou +11 more
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CaMKII-dependent regulation of cardiac Na(+) homeostasis. [PDF]
, 2014 Na(+) homeostasis is a key regulator of cardiac excitation and contraction. The cardiac voltage-gated Na(+) channel, NaV1.5, critically controls cell excitability, and altered channel gating has been implicated in both inherited and acquired arrhythmias.
Grandi, Eleonora, Herren, Anthony W
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